Objective To analyze the clinical effect of iodized lecithin tablets +ranibizumab +laser photocoagulation therapy in the treatment of patients with macular edema.Methods 46 cases of macular edema patients in our hospital were divided into the control group and the observation group according to the digital table, 23 cases in each group.The patients of the control group were treated with laser photocoagulation treatment;the patients in the observation group were given iodized lecithin tablets +ray natalizumab +laser photocoagulation treatment.The clinical effect, corrected visual acuity and the change of the thickness of the macular in two groups were compared.Results The total efficiency (95.65%) of the observation group was significantly higher than the control group ( 69.5%) ( P<0.05 ); after treatment, the visual acuity ( 0.53 ±0.16 ) and central macular thickness (278 ±45) μm of the observation group were significantly better than the control group with visual acuity (0.40 ±0.13) and central macular thickness (193 ±49) m, with statistically significant difference (P<0.05).Conclusion The clinical effect of macular edema patients receiving iodized lecithin tablets +ranibizumab +laser photocoagulation is good, effectively reduce macular edema, improve the patient’s vision, safe and effective.