There are some biological differences in epilepsy between the Asia and the West, mainly related to the young average age and the smaller physique among Asians. The climatic differences partly account for the higher prevalence of Japanese encephalitis and malaria, which remains important causes of acute symptomatic seizures in parts of Asia. By comparison, psychosocial, cultural, economic, political and organizational factors are much more important in influencing epilepsy causation, management and outcome in the region. With limited resources, the later should be given priority in research to improve epilepsy care in Asia.

Reeent advances in magnetic resonance imaging (MRI), in particular diffusion weighted imaging (DWI) and perfusion weighted imaging (PWI), have allowed clinicians to have the ability to differentiate between irreversible cerebral infarction and the potentially reversible ischemic penumbra. This article examines the principles and practice of DWI and PWI. With continued advances in thrombolysis and other therapy for acute cerebral ischemia, neuroimaging is poised to play an increasingly important role in decisionmaking in aeute stroke.

South East Asia has 8% of world population, but only has 2% of the total number of neurologists in the world. Seven of the 11 countries in South East Asia have training programmes in Neurology. Brunei, Laos, Malaysia, Myanmar and Singapore require prior training and certification in Internal Medicine before admission to training to Neurology. Most training programmes are 3 years in duration, inclusive of mandatory rotation to clinical neurophysiology. Assessment and certification processes are vigorous in most countries. Mature age, lack of funding, inadequate direct clinical responsibilities, and poor literacy in English are other issues in some of the countries. There is need to improve the quality as well as quantity in the training of neurologists in the region.
Training ; Certification ; Asia, Southeastern ; Clinical ; Training Programs

Stigma is conceptually broad and culturally variable. Understanding stigma from the conceptual theories, culturally application based on the word stigma in other languages, the definition of stigma and its synonyms, as well as the medical implications in other stigmatized disease such as AIDS, will help us to understand the complexity of stigma in epilepsy. This review investigated the meaning and types of stigma from different perspectives, leading to staging stigma into 5 levels, i.e. social identity, stereotype, prejudice, discrimination and social disability. In addition to the conventional categorization of stigma into social, felt, self-perceived or internalized stigma, new categories of stigma i.e. personal and general attitudes towards epilepsy based on a newly developed Public Attitudes Toward Epilepsy (PATE) scale was introduced. Courtesy stigma was further elaborated in related to Asian culture. Based on well-established and recently developed theories, the causation and impact of epilepsy stigma was discussed in an Asian context, especially from the aspects of language and society values which are culturally specific. Integrating these theories of causation, illness and stereotype perceptions were proposed to be the mediating mechanism of stigma, which led to the development of a practical and multi-dimensional stigmatization model, aiming to guide, widen and deepen the scope of future stigma research in epilepsy. Using the established model, together with review of related studies, research priorities in epilepsy stigma research especially in Asia focusing on five aspects, i.e. expanding population studies especially on significant others, understanding stigma from personal attitude perspective, investigating the cultural and social causation of stigma, and the impacts of stigma on patients as well as the family members, were proposed.

Tolosa-Hunt syndrome is typically associated with an infl ammatory lesion in the cavernous sinus or orbital fi ssure, often requiring steroids for symptom resolution. In this report, we describe a case of Tolosa-Hunt syndrome preceded by several years’ history of idiopathic recurrent facial palsies. The spontaneous resolution of THS in our case as well as prior facial nerve involvement supports the hypothesis that Tolosa-Hunt syndrome is part of a spectrum of idiopathic recurrent cranial neuropathy.

Between September 1998 to May 1999, Malaysia and Singapore were hit by an outbreak of fatal encephalitis caused by a novel virus from the paramyxovirus family. This virus was subsequently named as Nipah virus, after the Sungei Nipah village in Negeri Sembilan, where the virus was first isolated. The means of transmission was thought to be from bats-topigs and subsequently pigs-to-human. Since 2001, almost yearly outbreak of Nipah encephalitis has been reported from Bangladesh and West Bengal, India. These outbreaks were characterized by direct bats-to-human, and human-to-human spread of infection. Nipah virus shares many similar characteristics to Hendra virus, first isolated in an outbreak of respiratory illness involving horses in Australia in 1994. Because of their homology, a new genus called Henipavirus (Hendra + Nipah) was introduced. Henipavirus infection is a human disease manifesting most often as acute encephalitis (which may be relapsing or late-onset) or pneumonia, with a high mortality rate. Pteropus bats act as reservoir for the virus, which subsequently lead to human spread. Transmission may be from consumption of food contaminated by bats secretion, contact with infected animals, or human-to-human spread. With wide geographical distribution of Pteropus bats, Henipavirus infection has become an important emerging human infection with worldwide implication.

Since the initial outbreak in Malaysia, small outbreaks of Nipah encephalitis have been reported almost annually in Bangladesh. Epidemiological studies have shown that the virus could be transmitted from bat to human and from human to human. Wildlife studies have also shown that the virus was widely distributed in at least 10 genera and 23 species of bats in a large part of Asia and Africa – a region that stretches from Australia and southern China, and from Indonesia to as far west as Ghana, a region with a total population of more than 1.4 billion people. As bats are long distant flying, gregarious animals living in large colonies which could exchange novel viruses from one species to another, it is not unexpected that the seroprevalence of Henipavirus among bat colonies are relatively high. The widespread distribution of both the Henipavirus and its hosts also means that the virus will remain an important cause of zoonotic disease.

Since the initial outbreak of Nipah encephalitis in Malaysia in 1998, the virus has reemerged in Bangladesh and the adjacent Indian state of West Bengal since 2001. To date more than 470 patients have been affected with over 250 fatalities in total. Although the source of the virus is believed to be the Pteropus fruit bats both in Malaysia and Bangladesh, there are also significant epidemiological and clinical differences in the outbreaks occurring in these two regions. Epidemiologically, in the Bangladesh and India outbreaks, bat-to-human transmission through food and animal and human-tohuman transmissions were the predominant modes, the outbreaks were on a smaller scale and they have recurred every year except 2002 and 2006. Clinically, the mortality was higher and respiratory manifestation was more prominent in the Bangladeshi and Indian patients compared with their Malaysian counterparts, which might reflect differences in care and medical practices. There remain however, important differences in clinical manifestations which are likely to be due to some genetic variations in the virus.

Surveys about attitudes towards those with epilepsy have been performed since 1949, in order to understand the social stigma toward epilepsy. This review aims to demonstrate the variation in public attitudes towards epilepsy and its associated factors, with a critical review of the methodology used to examine attitudes towards epilepsy. There was marked variation of attitudes between Western and non-Western populations, and these attitudes were positively correlated with the standard of living. Besides the general public, studies were also performed within specifi c groups, particularly teachers and students. However absence of a standardized questionnaire makes direct comparison diffi cult. A few quantitative methods were developed but these were limited by cultural variations and thus lack of global acceptance. Short-term intervention studies demonstrate an improvement of attitude with knowledge. Nonetheless, the cultural and social reasons underlying the attitudes, and how this affects the life of people with epilepsy, are understudied. Therefore, surveys on attitudes should continue to be carried out, particularly in populations prone to have negative attitudes with emphasis on underlying reasons, and such progress should be monitored longitudinally. Attitudes of people such as parents, teachers, school counselors, health care professionals, and employers, which have a direct impact on people with epilepsy, should be more extensively studied.

Strong association between HLA B*1502 and carbamazepine-induced Steven-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) was demonstrated among Han Chinese in 2004. Studies from Europe showed that the HLA B*1502 is not a universal marker for SJS/TEN, but is ethnicity specific for Asians. Reports across Asia has shown that the prevalence of HLA B*1502 is high among Han Chinese (5-15%), Malays (12-15%), and Thais (8-27%), but low among Japan, Korea, Sri Lanka, and most ethnic groups in India. Other than Han Chinese, the association between HLA B*1502 and carbamazepine-induced SJS-TEN is also seen among the Thais and Malay. There is urgent need for further studies to determine the prevalence of SJS/TEN, and HLA B*1502 in the various ethnic groups in Asia, and its association with carbamazepine-induced SJS-TEN in each of these ethnic groups. In view of the significant morbidity and mortality in SJS-TEN, facilities should be developed to allow for screening of HLA B*1502 before carbamazepine is prescribed to the Hans Chinese, Malays and Thais. For those who experience no adverse cutaneous reaction after 3 months use of carbamazepine, the risk of SJS/TEN is low, and the drugs can be continued.