No abstract available.
Chitosan*

Antimicrobial activities of hydrogel burn wound dressing and chitosan were investigated against nine strains of bacteria and fungi, including P. aeruginosa, S. aureus, Enterobacter, P. vulgaris, P. mirabilis, E. coli, Klebsiella, B. subtilis, C. albicans. The results showed that both hydrogel dressing and chitosan have antimicrobial effect and the effect of hydrogel dressing is higher than that of chitosan. Antimicrobial activity of hydrogel dressing in experiment in rabbit was also tested.
burns ; chitosan

Quaternized chitosan was synthesized and structurally determined. The result showed that N,N,N-trimethylchitosan had a significant lowering cholesterol effect in blood of rats and rabbits in comparison to cholestyramine. Moreover TMC did not decrease the HDL-C (High Density Lipoprotein Cholesterol) used in treatment of arteriosclerosis.
chitosan ; Cholesterol

The chitosan produced from carapace of shrimp was used under cream form with concentration of 2% to treat experiment thermal burn wounds on 30 rabbits. Two thermal burn wounds were created on each rabbit, one of them was treated by excipient only or silver sulfadiazin cream 1% or maduxin ointment. The experimental results showed that:- Chitosan had antibacterial effect, especially on S.aureus, P.aeruginosa and E.coli. These dangerous bacteria resisted against many antibiotics. -The antibacterial effect of chitosan was similar to that of silver sulfadiazin and maduxin.
Chitosan, burns

A study on the histological changes in the experimental burn treated by chitosan cream, comparing with sulfadiazine-silver 1%, and maduxin ointment has shown that chitosan increased the process of tissue regeneration and wound healing. These activities were equivalent to these of sulfadiazine-silver cream 1% and maduxin ointment.
burns, chitosan

A total of 40 patients with asymptomatic HCV infection were involved in this study at Immunology Department of Military Hospital 108. Frequency of elevated transaminase was 27,5%. The change of amount of TCD4, TCD8, TCD3, B cell was found in 75%. Subjects were divided in to 2 groups: patients with asymptomatic HCV infection and elevated transaminase (group A) and asymptomatic HCV patients without elevated transaminase (group B). Number of TCD4, TCD8, TCD3, BCD19 increased significantly in group A, higher than in group B and controls. There was positive correlation between increasing TCD4, especially TCD8 with transaminase. Response of both T cell and B cell was shown in group A.
Chitosan ; Temperature

One method to determine the content of chitosan present in Pokysan cream has been developed. Chitosan was separated from Pokysan by dissolving the cream in acidic solution, extracted by chemical mixtures of I and II, which were prepared by laboratory of polymers in medico – pharmacy, and then collecting the precipitate of chitosan in the alkaline medium. This precipitate was then qualified by Lugol reagent and IR spectra. Collected chitosan precipitate was also qualified and quantified. These results proved that chitosan has been included in Pokysan cream and our method is confident
Chitosan ; Evaluation Studies ; Laboratories

Protein trace present in chitin/chitosan product has been determined by our proposed method in which protein trace included in chitin/chitosan was extracted by refraction in 10% NaOH solution at 100oC for 5 hours. Chitin/Chitosan precipitate was discarded. protein trace in the solution was restored by neutralizing with HCl 10N to get the yellow powder. This powder was then analyzed for total nitrogen content by Kjeldahl method. The control method was conducted at the same procedure excepted from the presence of 10% NaOH. The results of different chitin/chitosan samples obtained from these two methods showed that amount of protein trace obtained from above proposed method was somewhat higher than that of the control one. Besides, the purified chitosan sample gave the lower protein trace content than that of the technical chitosan sample as well as chitin one. Protein trace bound between macromolecules of chitin/chitosan was separated in the proposed method by boiling water under alkaline condition whereas it was not completely separated in the control method because sodium hydroxide was absent.
Chitin ; Chitosan ; Proteins

The preliminary in vitro susceptibilities of clinical isolated helicobacter pylori to chitosan were determined in 2 stages: 1) By testing for inhibitory activity against E.coli and P.aeruginosa, we have determined the suitable form of chitosan producing antibacterial activity was 1.7% transparent chitosan gel solution pH6. 2) The in vitro susceptibilities of 20 clinical H. pylori isolated to 1.7% transparent chitosan gel solution pH6 were determined by an agar dilution technique. The MIC value of chitosan against some H. pylori isolates ranged from 0.85 to 6.8mg/ml.
chitosan ; Helicobacter pylori

Purpose: Use experimental scheme to find some optimal conditions for reaction of acylized N-phtalyl chitosan stage. Material: green clawed shrimp shell. Preparing following modified water-heat method. Divide into 2 stages: Preparation N-phtalyl chitosan and soluble film created agent in the intestine in optimal conditions. Result: Derivative can be used to make a soluble film created agent in the intestine like CAP, HPMCP.
Chitosan ; Drug Compounding