1.Dysfunction of endothelial progentior cells in the angiographically defined coronary atherosclerosis
Sumiya Tserendavaa ; Odkhuu Enkhtaivan ; Tsogtsaikhan Sandag ; Chinzorig Ganbaatar ; Davaakhuu Sengebaljir ; Munkhzol Malchinkhuu
Mongolian Medical Sciences 2018;183(1):3-8
Introduction:
Endothelial progenitor cells (EPC) have a role in the maintenance and promotion of vascular repair and are negatively correlated with coronary atherosclerosis.
Goal:
To culture of EPC-CFUs during coronary atherosclerosis, evaluate endothelial nitric oxide synthetase (eNOS) enzyme levels in the culture.
Materials and Methods:
The 10 ml blood was drawn from the peripheral vein of 12 man patients that stable angina 4, acute myocardial infarction (AMI) 4 and healthy people 4. Peripheral blood mononuclear cells were isolated by Ficoll density-gradient centrifugation and EPC-CFUs was assayed after two platings and a 6 day culture on fibronectin coated, 72 well plates, as described. eNOS enzyme titers were determined by ELISA according to the protocol in the cells culture.
Results:
The people were 52±2.12 years. The number of EPC-CFUs increases with accordance of patients with stable angina, AMI, healthy people with the statistical significance (F=17.3, p<0.001): stable angina (2.6±0.47 colony/well), AMI (6.7±0.81 colony/well), healthy people (10.5±1.34 colony/well). Furthermore, ANOVA test of eNOS enzyme levels in patients with stable angina (5.2±0.61 pg/ml), AMI (8.7±1.49 pg/ml) and healthy people (13.7±2.48 pg/ml). The significant difference (F=6.2, p=0.003) was observed among the three groups. The number of EPC-CFUs had direct significantly correlation (r=0.621, p<0.001) with the eNOS enzyme levels of this culture.
Conclusion:
Number of EPC-CFUs and eNOS enzyme levels decrease at patient with stable angina, indicate more than endothelial dysfunction.
Ethical approval
The ethics committee of Mongolian National University of Medical Sciences (ID: 6/3/201506, approved on Jan 01, 2015)
2.Surgical treatment and survival rate from colorectal cancer in Mongolia
Ganbaatar R ; Chinzorig M ; Tuvshin B ; Erdene-Ochir Ya ; Jargalsaikhan D ; Erkhembayar E ; Bat-Оrgil Ch ; Khaliunaa B ; Batzorig B ; Ulziisaikhan B
Mongolian Medical Sciences 2021;197(3):59-63
Introduction:
In 2018, the overall colorectal cancer (CRC) incidence rate was 3.6%, according to the
National Cancer Center of Mongolia (NCCM), and the incidence of colorectal cancer has increased
slightly in recent years. According to cancer stages, late stage cancer has a 5-year survival rate of
51%, while early stage cancer has a 5-year survival rate of 79%. The overall survival rate of colorectal
cancer in Mongolia has not been studied in precisely. In Asia, the 5-year survival rate for colorectal
cancer was 60%. Therefore, this study investigated the colorectal cancer survival rate and prognostic
factors at NCCM.
Methods:
A total of 108 patients diagnosed with CRC at NCCM’s General Surgery Department from
2013 to 2015 were used in this retrospective cohort study. The Kaplan-Meier method was used to
develop the survival graphs, which were then compared using the Log-rank test.
Results:
The median survival time was 42 months, with a 95% CI (38.55-45.66). A 5-year period,
the overall survival rate for CRC was 61.2%. Survival rates at the I, II, III, and IV stages were 100%,
75%, 65.4%, and 13.5%, respectively. There was a significant difference in CRC survival rates across
all stages (p=0.0001). There was a statistically significant difference in determining the relationship
between adjuvant chemotherapy and survival rate (p=0.0003).
Conclusion
The outcome of the surgery is determined by the CRC stage. The postoperative survival
rate (61.2%) is directly related to tumor stage, peripheral glandular metastasis, distant metastasis,
and chemotherapy effects.