1.Marked therapeutic effect of erythromycin in a patient with severe constipation during cancer pain relief treatment
Norio Watanabe ; Takuya Yamada ; Chikako Yoshida ; Sachiko Hosokawa ; Chigusa Nakagawa ; Mikio Yasumura ; Keiko Yamamura
An Official Journal of the Japan Primary Care Association 2016;39(1):40-42
2.A Survey of the Current Status of Fentanyl Sublingual Tablets and Evaluation of Problems Associated with Their Proper Use
Norio Watanabe ; Sachiko Hosokawa ; Takuya Yamada ; Chikako Yoshida ; Akiko Suzuki ; Naruhito Anbe ; Masaya Ito ; Ikie Niwa ; Keiko Yamamura
An Official Journal of the Japan Primary Care Association 2017;40(1):27-32
Objectives: A survey was conducted to investigate the usability and safety of fentanyl sublingual tablets (FST) and to examine problems associated with their proper use.
Methods: Subjects were 18 cancer inpatients who received FST for breakthrough pain in their pharmacological cancer pain management. Changes in the pain score and the occurrence of adverse effects (nausea, vomiting and somnolence) were compared before and after FST administration.
Results: The pain score before FST administration was 6.4±2.4, and this was significantly improved to 3.4±2.8 at 30 min after administration (p<0.01). Somnolence occurred significantly more often 30 min and 2 h after FST administration than immediately before administration (p<0.05). There were no differences in the occurrence of nausea and vomiting before or after FST administration. Nine patients receiving FST therapy developed xerostomia, but there were no significant changes in the pain score or occurrence of adverse effects while they had xerostomia.
Conclusion: It is essential to observe the oral condition to judge whether FST therapy is indicated, and FST should be administered after providing sufficient oral care. The results indicate the possibility of increased occurrence of somnolence as an adverse effect.
3.Effect of the Hot Water Extract of Coix lacryma-jobi L. var. ma-yuen Stapf with Husks on Skin Improvement
Shizuka UEHARA ; Chikako YOSHIKAWA ; Mitsuru YOSHIDA ; Makoto MIZUNO ; Akemi RYU ; Hoko KYO ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2019;16(1):33-38
We examined the influence of hot water extract of coix seed (Coix lacryma-jobi L. var. ma-yuen Stapf) with husks on facial skin. Ten females (28-58 years old) took hot water extract of coix seed with husks 1 g/day for 8 weeks, and various skin parameters were measured. The results showed that the total amount of subsurface reflection of blue light, which is an index of skin translucency, increased significantly after 8 weeks of intake (p = 0.011). In addition, skin texture improved significantly after 4 and 8 weeks of intake (p = 0.007, p = 0.042). Additionally, the condition of tape-stripped stratum corneum also indicated significant improvement after 4 and 8 weeks intake (p = 0.0002, p = 0.020). These results suggested that the hot water extract of coix seed with husks exhibited effects even at 1 g/day, which is less than in previous reports.
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