Objective To explore the efficacy and safety of high-dose methotrexate (MTX) and L-asparaginase (L-Asp) for the treatment of adult patients with high risk Ph acute lymphoblastic leukemia (ALL).Methods Five adult patients with high risk Ph-ALL were treated with several courses of MTX (3-5 g/m2 by continually intravenous drip for 24 h) and L-Asp (8 000-10 000 U/time, once a day, 10 times for one cycle).Results Five patients were disease-free survival, their survival time was 60-96 months and the median survival time was 73 months.The chemotherapy-related bone marrow depression was mild.No obvious liver and kidney damage, severe allergic reaction and pancreatitis were observed.Conclusion Highdose MTX and L-Asp are effective and well tolerated, and may contribute to long-term survival of adult patients with high risk Ph-ALL.

Breast cancer as one of the common malignant tumors in women, has received widespread attention. Aerobic glycolysis is the main metabolic pathway of breast cancer cells, and its key enzymes play an important role in the metabolism of cancer cells. The key enzymes of glycolysis are regulated by the Wnt/β-catenin signaling pathway. Abnormal activation of the Wnt/β-catenin signaling pathway regulates downstream target genes, thereby affecting the activities of key glycolysis enzymes. Glycolysis and Wnt/β-catenin signaling pathway play an important role in the occurrence and development of breast cancer, but the specific regulatory relationship between the two has not been studied in depth. Therefore, this article summarizes the regulation relationship between aerobic glycolysis and Wnt/β-catenin pathway in order to explore new strategies for breast cancer treatment.