Objective To observe the feasibility of 125I intra-operative implantation plus palliative resection of gastric carcinoma for treatment of advanced gastric cancer infiltrating pancreas. Methods 125 I was implanted intraoperatively into the residual pancreatic cancer tissues after gastric carcinoma was palliatively removed. Results From Feb. 2005 to Jun. 2009, 15 cases (9 male, 6 female) advanced gastric cancer patients were treated with 125 I intra-operative implantation. The patients' ages ranged from 41 to 78 years, with the median age of 64 years old. There were 10 cases of gastric cancer infiltrating the neck or body of pancreas and 5 cases infiltrating pancreatic head. No severe post-operative complications were recorded. The follow-up showed that there were 5 cases of CR (33.3%), 9 cases of PR (60%), 1 case of NC (6.7%) and no PD patients were found. Conclusion 125I intra-operative implantation plus palliative gastric resection is feasible and effective for patients of advanced gastric cancer infiltrating the pancreas.