1.Curative effect of trigeminy treatment on ulcerative bedsore
Minfang FENG ; Haifang BIAN ; Chengyao FU
Chinese Journal of Practical Nursing 2009;25(3):45-46
Objective To determine the curative effect of a trigeminy treatment including gen-tamycin, albumin and local oxygen therapy on treatment of ulcerative bedsore. Methods 50 cases of hospitalized patients in our hospital with ulcerative bedsore during January,2005 to December,2007 were selected. The patients were randomly classified into the experimental group and the control group with 25 patients in each group. The patients in the experimental group were treated by trigeminy treat-ment after debridement, while the patients in the control group were treated by covering with gen-tamycin and bandaging with dressing after debridement.The therapeutic effect of the two groups was compared by χ2 test. Results After the treatment, 6, 10, 6 and 3 patients in the experimental group, were healing, excellence, utility and inefficacy, respectively. On the contrast in the patients of the con-trol group, 2, 8, 5 and 10 were judged as healing, excellence, utility and inefficacy, respectively. The experimental group showed better effect than the control group. Conclusions The trigeminy treat-ment is able to remarkably increase clinical treatment effect of ulcerative bedsore.
2.Effects of stromal cell-derived factor-1α on senescence of endothelial stem cells from peripheral blood
Yibin MEI ; Hao ZHENG ; Guosheng FU ; Chengyao WANG ; Naijun JI ; Changsheng HU
Chinese Journal of Pharmacology and Toxicology 2010;24(1):19-24
OBJECTIVE To investigate whether stromal cell-derived factor-1α (SDF-1α) might be able to prevent senescence of endothelial stem cell (ESC) and also study its effects on the telomerase activity. METHODS Total mononuclear cells (MNCs) were isolated from peripheral blood by density gradient centrifugation, and then the cells were plated on fibronectin-coated culture dishes. After cultured for 4 d, attached cells were divided into control and SDF-1α 1, 10, 50 and 100 μg·L~(-1) groups. ESC became senescent as determined by acidic β-galactosidase staining. The proliferation of ESC was assessed by MTT assay and colony-forming capacity. Telomerase activity was measured by telomerase-PCR ELISA and the phosphorylation of Akt was determined by using Western blotting. RESULTS Ex vivo prolonged cultivation of ESC led to rapid onset of ESC senescence. Compared with control group, SDF-1α concentration-dependently inhibited the onset of ESC senescence, maximum at 100 μg·L~(-1) (40.8±7.1 vs 17.5±3.0; P<0.01). Moreover, SDF-1α 100 μg·L~(-1) increased ESC proliferation (0.22±0.02 vs 0.39±0.04; P<0.01) and ESC colony-forming activity (7.8±2.2 vs 22.4±3.4). Compared with control group, SDF-1α 100 μg·L~(-1) also increased telomerase activity (0.34±0.05 vs 0.57±0.09; P<0.01). In addition, SDF-1α treatment of ESC stimulated a concentration- and time-dependent Akt phosphorylation. CONCLUSION SDF-1α-induced prevention of ESC senescence leads to the potentiation of proliferative activity, and clonal expansion, which may be related to the activation of telomerase and Akt phosphorylation.
3.Chinese Society of Allergy and Chinese Society of Otorhinolaryngology-Head and Neck Surgery Guideline for Chronic Rhinosinusitis
Zheng LIU ; Jianjun CHEN ; Lei CHENG ; Huabin LI ; Shixi LIU ; Hongfei LOU ; Jianbo SHI ; Ying SUN ; Dehui WANG ; Chengshuo WANG ; Xiangdong WANG ; Yongxiang WEI ; Weiping WEN ; Pingchang YANG ; Qintai YANG ; Gehua ZHANG ; Yuan ZHANG ; Changqing ZHAO ; Dongdong ZHU ; Li ZHU ; Fenghong CHEN ; Yi DONG ; Qingling FU ; Jingyun LI ; Yanqing LI ; Chengyao LIU ; Feng LIU ; Meiping LU ; Yifan MENG ; Jichao SHA ; Wenyu SHE ; Lili SHI ; Kuiji WANG ; Jinmei XUE ; Luoying YANG ; Min YIN ; Lichuan ZHANG ; Ming ZHENG ; Bing ZHOU ; Luo ZHANG
Allergy, Asthma & Immunology Research 2020;12(2):176-237
The current document is based on a consensus reached by a panel of experts from the Chinese Society of Allergy and the Chinese Society of Otorhinolaryngology-Head and Neck Surgery, Rhinology Group. Chronic rhinosinusitis (CRS) affects approximately 8% of Chinese adults. The inflammatory and remodeling mechanisms of CRS in the Chinese population differ from those observed in the populations of European descent. Recently, precision medicine has been used to treat inflammation by targeting key biomarkers that are involved in the process. However, there are no CRS guidelines or a consensus available from China that can be shared with the international academia. The guidelines presented in this paper cover the epidemiology, economic burden, genetics and epigenetics, mechanisms, phenotypes and endotypes, diagnosis and differential diagnosis, management, and the current status of CRS in China. These guidelines—with a focus on China—will improve the abilities of clinical and medical staff during the treatment of CRS. Additionally, they will help international agencies in improving the verification of CRS endotypes, mapping of eosinophilic shifts, the identification of suitable biomarkers for endotyping, and predicting responses to therapies. In conclusion, these guidelines will help select therapies, such as pharmacotherapy, surgical approaches and innovative biotherapeutics, which are tailored to each of the individual CRS endotypes.
Adult
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Asian Continental Ancestry Group
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Biomarkers
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China
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Consensus
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Diagnosis
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Diagnosis, Differential
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Drug Therapy
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Eosinophils
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Epidemiology
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Epigenomics
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Genetics
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Humans
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Hypersensitivity
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Inflammation
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International Agencies
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Medical Staff
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Neck
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Phenotype
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Precision Medicine