1.Curative effects of pulsed electromagnetic fields on postmenopausal osteoporosis.
Huifang LIU ; Ying LIU ; Lin YANG ; Chunyan WANG ; Yuanchao WU ; Chengqi HE
Journal of Biomedical Engineering 2014;31(1):48-52
We investigated the effects and optimal treatment frequency of pulsed electromagnetic fields (PEMFs) on postmenopausal osteoporosis (PMO). A comparison was performed with the cyclical alendronate and a course of PEMFs in the treatment for postmenopausal osteoporosis on bone mineral density (BMD), pain intensity and balance function. There was no significant difference between the two groups on mean percentage changes from baseline of BMD within 24 weeks after random treatments (P > or = 0.05). However, at the ends of 48 weeks and 72 weeks, the BMD of the PEMFs group were significantly lower than that of the alendronate group (P < 0.05). No significant difference was detected between the two groups with regard to treatment effects on Visual Analogue Scale score, the Timed Up & Go Test and Berg Balance Scale score. Compared with cyclical alendronate, a course of PEMFs was as effective as alendronate in treating PMO for at least 24 weeks. So its optimal treatment frequency for PMO may be one course per six months.
Alendronate
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therapeutic use
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Bone Density
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Bone Density Conservation Agents
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therapeutic use
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Electromagnetic Fields
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Female
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Humans
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Magnetic Field Therapy
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Osteoporosis, Postmenopausal
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therapy
2.Effect of muscle stimulating instrument on patients with cerebral palsy after microsurgical neurotomy of peripheral nerves
Yan-bing YU ; Li ZHANG ; Wei WANG ; Chengqi WU ; Wenwei ZHANG
Chinese Journal of Rehabilitation Theory and Practice 2004;10(2):92-93
ObjectiveTo observe the effect of muscle stimulating instrument on patients with cerebral palsy after microsurgical neurotomy of peripheral nerves.Methods77 patients with cerebral palsy after microsurgical neurotomy of peripheral nerves were divided into the treatment group (39 cases) and the control group (38 cases). Patients of two groups were treated with routine rehabilitation training, but muscle stimulating instruments treatment was added to patients of the treatment group. The muscle strength and motor ability of patients of two groups were followed up and compared.ResultsThe muscle strength and motor ability of the treatment group were better than that of control group during follow-up period(P<0.01).ConclusionMuscle stimulating instrument can accelerate the recovery of muscle strength and motor ability in patients with cerebral palsy after microsurgical neurotomy of peripheral nerves.
3.Effect of osteophytes on bone mineral density of female lumbar spine.
Deng XIAO ; Qinglu LUO ; Chengqi HE ; Lin YANG ; Hongchen HE ; Yuanchao WU
Journal of Biomedical Engineering 2010;27(3):586-589
Previous case-control studies have shown various degrees of inverse correlation between osteoarthritis (OA) and osteoporosis (OP). The aim of this study was to examine the relationship between osteophytes at the cervical , lumbar vertebrae and knee, and the bone mineral density (BMD) of lumbar spine. We analyzed the data on 4091 female patients (aged 13 to 92 years). Osteophyte was defined by X ray examination. BMD of the lumbar spine (LS) was measured by dual energy X-ray absorptiometry (Lunar DPX). The association of osteophytes with BMD and osteophytes at different sites and different degrees were assessed by covariance analysis. Adjustments were made for age and body mass index. The relationship between osteophytes and BMD was analyzed by Binary Logistic Regression. BMD at each site was greater in the female with osteophytes (L4 BMD: P < 0.01, Mean BMD: P < 0.05); the relationship between osteophytes and osteoporosis and that between duration of osteophytes and osteoporosis were inversely correlated (P < 0.01). It confirms the existence of an inverse relationship between osteophytes and OP while a positive relationship is between age, body mass index and osteoporosis.
Absorptiometry, Photon
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Adolescent
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Adult
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Aged
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Aged, 80 and over
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Bone Density
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Female
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Humans
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Lumbar Vertebrae
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metabolism
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pathology
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Middle Aged
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Osteophyte
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metabolism
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Osteoporosis
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metabolism
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Young Adult
4.Study on the relationship between body mass index and osteoporosis in males.
Qinglu LUO ; Hongchen HE ; Lin YANG ; Chengqi HE ; Yuanchao WU ; Enfu XIONG ; Wei XIE
Journal of Biomedical Engineering 2010;27(2):311-314
There were 482 male patients with non-hyperostosis diagnosed by X-ray among 1207 males who visited West China Hospital because of pain and/or numbness in bone or/and in joints from August 2003 to December 2005; the base-line information in records included age, stature, body weight(calculated BMD, symptoms, co-morbidities, exercise frequency, and smoking. The bone mineral density of lumbar spine was determined and used to judge osteoporosis or non-osteoporosis. Comparison was made on the basic information between osteoporosis group and non-osteoporosis group by t test or chi2 test statistical analysis; the relationship of multiple factors with osteoporosis was analyzed by Logistic Regression. The results of comparison between osteoporosis group and non-osteoporosis group indicated, there were significant differences among BMI, exercise and smoking, but no significant differences were seen among age, complications of hypertension and diabetes mellitus. According to the results of multiple regression analysis, BMI and smoking are the risk factors of osteoporosis, yet exercise is the protection factors of osteoporosis; the risk of osteoporosis increases by 0.654 times in men with BMI scaling up by 1 kg/m2 (P = 0.004). Therefore, we conclude that BMI is a risk factor of osteoporosis in male, and it may be related to body fat distribution.
Adolescent
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Adult
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Aged
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Aged, 80 and over
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Body Mass Index
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Child
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China
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epidemiology
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Exercise
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Humans
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Male
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Middle Aged
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Osteoporosis
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epidemiology
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etiology
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Prevalence
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Risk Factors
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Smoking
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Young Adult
5.On correlation between body mass index and lumbar spine average bone mineral density: a study in male patients with osteopenia and those with osteoporosis.
Haidan LIN ; Qinglu LUO ; Chengqi HE ; Lin YANG ; Hongchen HE ; Yuanchao WU ; Qun LAN ; Wei XIE ; Enfu XIONG
Journal of Biomedical Engineering 2010;27(1):138-141
From among the patients who visited the Dept. of Rehabilitation of West China Hospital for arthalgia in the period from Aug. 2003 to Dec. 2005, we recruited 566 male patients who were over 40 years of age and did not have hyperostosis in the lumbar spine, and whose T scores were each less than--1. Their ages ranged from 40 to 93 years, and the average age was 62.93 +/- 13.50. The dual-energy X-ray absorptiometry from DMS Company in France was used to measure the bone density of the L2-4 anterior-posterior. The basic data about the subjects, containing the age, height, weight, diabetes mellitus, exercise and smoking or not, were recorded. Then the body mass index were calculated. In accordance to the T score, the subjects were separated into two groups: osteopenia group and osteoporosis group. In comparison of the basic data between groups, BMI of osteoporosis group was significantly higher than that of the osteopenia group, but the number of the subjects who exercised was smaller (P < 0.05). Multiple linear regression analysis revealed that in the case BMI increased by 1 kg/m2, BMD significantly decreased by 0.003 g/cm2 (P = 0.002), and the age negatively correlated with BMD (B = -0.001, P = 0.035). "Exercise or not" was positively related to BMD (B = 0.028, P = 0.000). "Smoking or not" and BMD were not significantly correlated (P = 0.837). In conclusion, increase of BMI, or we may say, increase of fat, would decrease the lumbar spine average BMD in the patients of osteoporosis or osteopenia. Some reports have pointed out that only by increasing BMI with increased amount of muscles, but not with increased amount of fat, would be beneficial to the prevention of osteoporosis. So we concluded that the muscle amount in the subjects should be taken into account when we probe into the relation between BMI and BMD.
Adult
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Aged
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Aged, 80 and over
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Body Composition
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Body Mass Index
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Bone Density
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Bone Diseases, Metabolic
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metabolism
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Humans
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Lumbar Vertebrae
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metabolism
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Male
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Middle Aged
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Osteoporosis
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metabolism
6.Surgical manmgement with free flap in repairing hemifacial atrophy in 19 cases
Chengqi WU ; Feng XIE ; Zhenjun XIE ; Hao LI ; Hongfeng ZHAI ; Guohong ZHAO ; Kai WANG
Chinese Journal of Microsurgery 2018;41(2):142-144
Objective To investigate the long-term effect of free flap in repairing hemifacial atrophy.Methods From April,1991 to April,2015,19 cases (5 males and 14 females) aged between 18 and 51 years (mean,26 years) with hemifacial atrophy were treated by free flap.Hemifacial atrophy affected the left side in 8 patients,and the right side in the remaining 11.Fifteen cases only had a hemifacial soft tissue deficit,the other 4 cases were associated with ipsilateral zygoma dysplasia,in which 1 had ipsilateral scar contracture.The latissimus dorsi muscle flap were applied in 12 cases (2 of which anastomose thoracodorsal nerve with the cervical branch of the facial nerve),the scapular flap in 2 cases,the tensor fascia latae dermal flap with dermal fat flap in 3 cases,and with iliac groin composite tissue flap and ilium groin dermal composite tissue flap in 1 case respectively.Among them,14 flaps had their blood vessels anastomosed to the superficial temporal artery and vein,and 5 to the facial artery and vein.All operations were successfuly accomplished and followed-up for 2-21 years.Results All patients had ideal clinical outcomes with significant improvement in facial symmetry and skin color,and no dysfunction happened.Conclusion The long-term effect of surgical management with free flap in repairing hemifacial atrophy is satisfactory.It is an effective method of clinical treatment.
7.Effect of body mass index on bone mass of lumbar spine of male patients with ostealgia and arthralgia but without osteoporosis.
Jinlong ZHANG ; Qinglu LUO ; Chengqi HE ; Lin YANG ; Hongchen HE ; Yuanchao WU ; Wei XIE ; Enfu XIONG
Journal of Biomedical Engineering 2009;26(4):852-860
For the purpose of identifying the effect of body mass index on bone mineral density, an investigation was made in regard to the relationship between body mass index (BMI), bone mineral density (BMD) and bone mineral content (BMC) of lumbar vertebrals of men without osteoporosis. 838 male patients were diagnosed and treated in West China Hospital of Sichuan University because of ostealgia and arthralgia from Aug. 2003 to Dec. 2005. They were examined by dual-energy X-ray absorptiometry, their L2-L4 bone mineral density being < -2.5SD. Then they were graded by body mass index (Kg/m2) [1st group BMI > or =23, 454 cases (Group A BMI > or = 29, 46 cases; Group B 25 < or = BMI < 28.9, 201 cases; Group C 23 < or = BMI < 24, 9193 cases); 2nd group 18.5 < BMI < 22.9, 311 cases; 3rd group BMI < or = 18.5, 68 cases]. The relationships between BMI and BMD of lumbar spine were analyzed using SPSS 13.0. The results revealed their positions in series: (1) Among Groups 1-3, BMD, average BMD and aBMC of L2-L4 being 3rd group > 2nd group > 1st group, the differencs are statistically significant (P < 0.05 or P < 0.01); BMC, aBMC of L3 and L4 and aBMC of L2 being 3rd group > 2nd group > 2nd group, the differences are significant (P < 0.01); besides BMC of L2 and T-score,the differencs among three groups are not statistically significant (P > 0.05); (2) Among the 1st group, BMD and average BMD of L2-L4 being Group C > Group B > Group A,the differencs are significant (P < 0.05 or P < 0.01); BMC, aBMC of L and I being Group C > Group B > Group A,the differences among the three groups are significant (P < 0.05 or P < 0.01); BMC, aBMC of L3 and L4 and aBMC of L2 being Group C > Group B > Group A, the differences are significant, besides BMC of L2 and T-score,the differences among three groups are not significant (P > 0.05), (3) BMI correlated negatively (P < 0.01, r = -0.189) to the average BMD of lumbar spine. The average BMD of lumbar spine decreases when BMI increases in males without osteoporosis. When obesity is more obvious, the decrease in average BMD of lumbar spine bone is more evidently decreased. The decrease of BMD, BMC and total BMC in L3 and L may be greater than that in L2.
Absorptiometry, Photon
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Aged
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Arthralgia
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diagnostic imaging
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metabolism
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Body Composition
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physiology
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Body Mass Index
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Bone Density
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Humans
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Lumbar Vertebrae
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diagnostic imaging
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metabolism
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Male
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Middle Aged
;
Osteoporosis
8.Molecular mechanism of damage and repair of mouse thymus lymphocytes induced by radiation.
Yufang CUI ; Hong YANG ; Shuxia WU ; Linlu GAO ; Yabing GAO ; Ruiyun PENG ; Xuemei CUI ; Chengqi XIONG ; Wenhua HU ; Dewen WANG
Chinese Medical Journal 2002;115(7):1070-1073
OBJECTIVETo investigate the role of apoptosis in radiation-induced mouse thymus lymphocyte damage and repair and provide the basis for understanding the molecular mechanism of radiation-induced lymphocyte damage and repair as well as the prevention and treatment of acute radiation sickness.
METHODSWe studied the dynamic changes of apoptosis of mouse thymus lymphocytes and the expression of bax and bcl-2 gene products after 2, 4, 6 and 8 Gy of whole body gamma-irradiation using in situ terminal labeling, DNA electrophoresis and immunohistochemical techniques.
RESULTSAt the early stage after irradiation, the percentage of apoptotic lymphocytes increased rapidly in accordance with the increasing of radiation doses, while the counts of the thymus and peripheral lymphocytes decreased sharply, showing an opposite change to lymphocyte apoptosis. After 6 Gy gamma-irradiation, typical morphological characteristics of thymus apoptotic lymphocytes in early, middle and late stages were found by transmission electron microscopy. The thymus lymphocytes displayed characteristic DNA ladders 4 hr and 8 hr after 2-6 Gy gamma-irradiation,using DNA gel electrophoresis techniques. Abnormal expression of bcl-2 and bax gene products were shown in irradiated lymphocytes.
CONCLUSIONSApoptosis plays an important role in the process of radiation-induced mouse thymus lymphocyte damage and repair. Bcl-2 and Bax proteins may regulate the process of lymphocyte apoptosis.
Animals ; Apoptosis ; radiation effects ; Dose-Response Relationship, Radiation ; Gamma Rays ; Lymphocytes ; physiology ; radiation effects ; Male ; Mice ; Proto-Oncogene Proteins ; analysis ; Proto-Oncogene Proteins c-bcl-2 ; analysis ; Thymus Gland ; pathology ; radiation effects ; Time Factors ; bcl-2-Associated X Protein
9. Current status of blood lipids in people with hypertension and diabetes in Henan province
Xinyun LIU ; Wenlu XING ; Jicheng JIANG ; Chuanyu GAO ; You ZHANG ; Shan WANG ; Gang ZHOU ; Lianxin DU ; Chengqi WU ; Gang HOU ; Yuming WANG
Chinese Journal of Cardiology 2019;47(5):360-366
Objective:
To investigate the blood lipid levels and prevalence of dyslipidemia in people with hypertension and diabetes in Henan province.
Methods:
From April 2016 to April 2017, multi-stage cluster sampling was adopted to investigate 71 285 local residents aged between 35 and 75 from 6 districts and counties in Henan province including Zhongmu county of Zhengzhou city, Huojia county of Xinxiang city, Hualong district of Puyang city, Qi county of Hebi city, Xigong district of Luoyang city, and Wugang city of Pingdingshan city. Blood samples were collected. According to the diagnostic criteria of hypertension and diabetes, the study population was divided into control group (