1.Evaluation of the value of glomerular filtration rate in the severity of coronary artery stenosis in elder people
Jian LI ; Chenglei HUANG ; Rongying ZHU ; Xuling XU ; Xinping LUO ; Yong LI ; Haiming SHI
Chinese Journal of Geriatrics 2009;28(8):645-648
ObjectiveTo assess the relationship between the estimated glomerular filtration rate (eGFR) and the severity of coronary artery stenosis in elder people. MethodsSix hundred and fifty-seven patients who underwent selective coronary artery angiography were divided into 3 groups according to age: group Ⅰ (202 patients aged <60 years), group Ⅱ (181 patients aged from 60 to 69 years) and group Ⅲ (274 patients aged ≥70 years). According to the simplified MDRD equation,impaired renal function and severe renal dysfunction, respectively. Clinical features and the severity of coronary artery stenosis were compared among the 3 groups. ResultsThe level of average eGFR tended to he decreased with the narrowed coronary arteries. The difference of average eGFR between patients with muhivessel versus two-vessel coronary artery disease was of statistical significance in Group Ⅲ(P = 0. 035). After controlling for the effects of smoking, hypertension, dyslipidemia,aging, and diabetes, the Gensini score which reflected the severity of coronary artery stenosis was negatively correlated with the level of eGFR (r =-0. 110, P = 0. 005). ConclusionsIt suggests that the eGFR decrease is associated with the severity of coronary artery stenosis, and there is a linear correlation between eGFR and Gensini score in elder people, eGFR can be used to evaluate the severity of coronary artery disease and prognosis.
2.Research advances in targeted therapy for hepatocellular carcinoma
Shen HUANG ; Chenglei YANG ; Zhiming ZHANG
Journal of Clinical Hepatology 2019;35(11):2573-2577
Hepatocellular carcinoma (HCC) is one of the most common malignant tumors. Due to the insidious onset, poor prognosis, and lack of specificity of HCC, most patients have reached the advanced stage at the time of diagnosis. Conventional treatment methods, such as surgical resection, liver transplantation, radiotherapy, and chemotherapy, have limited therapeutic effects and fail to bring significant benefits to patients. With the improvement of science and technology and medical level in recent years, targeted therapy drugs have gradually entered people’s vision due to the breakthroughs in the treatment of HCC and thus bring new hope to patients with advanced HCC. Targeted drugs have attracted wide attention due to good molecular selectivity, targeted killing of tumor cells, and protection of normal tissue. This article reviews the research advances in targeted therapy for HCC.
3.Mechanism of action of protein phosphatase 2A in the promotion and inhibition of hepatocellular carcinoma
Chenglei YANG ; Shen HUANG ; Zhiming ZHANG
Journal of Clinical Hepatology 2019;35(5):1123-1128
Protein phosphatase 2A (PP2A) is a major serine/threonine phosphatase involved in many signaling pathways associated with cell growth and proliferation, and it also regulates many cellular processes. With an in-depth exploration of PP2A in the process of cell activity, especially malignant tumors, the association between PP2A and hepatocellular carcinoma (HCC) has attracted more and more attention in recent years; however, there is still a controversy over whether PP2A can promote or inhibit HCC. This article reviews the research advances in the mechanism of action of PP2A as a tumor factor in the regulation of HCC and target therapy.
4.Roles of Tet2 in meiosis, fertility and reproductive aging.
Huasong WANG ; Linlin LIU ; Mo GOU ; Guian HUANG ; Chenglei TIAN ; Jiao YANG ; Haiying WANG ; Qin XU ; Guo Liang XU ; Lin LIU
Protein & Cell 2021;12(7):578-585