Objective To study the efficacy and safety of sedation in gastroscopy with a combined use of rimifentani and propofol compared to a control,non-sedative group.Methods 120 cases in sedative group were given intravenous rimifentani and propofol.Patients'feeling and discomfort,operator's satisfaction and operative duration were compared with the controI group(n=120,without sedation).The changes of blood pressure,heat rate and blood oxygen saturation were recorded and analysed.Results 118 patients(98.3%)in sedative group and 0 patient(0)in control group did not complain any discomfort and pain duing gastroscopy(P＜0.01).The incidence of cough,restlessness,nausea and vomiting,and guttural discomfort in sedative group(1.7%,3.3%,1.7%,and 0,respectively)was lower as compared with the control group(9.2%,26.7%,48.3%and 100%,respectively,P＜0.01).The blood pressure in sedative group was decreased duing the procedure and recovered after the procedure.Conclusion With intravenous use of rimifentani and propofol,gastroscopy can be performed effectively and safely.