1.Application of Mild hypothermia in Cardio-Pulmonary-Cerebral Resuscitation
International Journal of Cerebrovascular Diseases 2006;0(02):-
Therapeutic hypothermia used for clinical purposes has had a long history. With the continuous development in the intensive care and surface cooling techniques, it has made various large hypothermia clinical trials possible. Studies have found that moderate hypothermia (28~35℃) has significant protective effects on important organs such as heart and brain, and it does not have obvious side effects. Recently, mild hypothermia (32~35℃) has been widely used for cardio-pulmonary-cerebral resuscitation, and its effect is satisfactory.
2.Significance and clinical application of the changes of substantia nigra echogenicity detected by transcranial Doppler ultrasonography
Donghui LI ; Chengjie MAO ; Chunfeng LIU
International Journal of Cerebrovascular Diseases 2009;17(8):600-603
Substantia nigra is the largest nuclei in midbrain, which is divided into a compact part and a reticular part. Recent studies have shown that the changes of iron content in reticular part of substantia nigra results in the changes of substantia nigra echogenicity. The substantia nigra detected by transcranial Doppler, according to its echo changes, may provide help for the susceptibility of Parkinson's disease, latency and early diagnosis, as well as for the differential diagnosis of multiple system atrophy and vascular parkinsonism.
3.Nursing of stiff-man syndrome: a case report
Junying HUANG ; Chengjie MAO ; Chunfeng LIU
Chinese Journal of Practical Nursing 2013;(15):48-49
Objective To explore the nursing care for the stiff-man syndrome patient.Methods Retrospective analysis had been performed for the nursing care of a patient with stiff-man syndrome.Results After 4 weeks of careful treatment and nursing care,the patient was discharged from the hospital.Conclusions Suitable nursing according to patients' condition,medication monitoring,psychological care,safety nursing and health guidance can prevent or delay the development of the disease and promote comprehensive rehabilitation for patients.
4.Factors affecting the quality of life in patients with Parkinson's disease
Chengjie MAO ; Yanbo CHENG ; Chunfeng LIU
Journal of Clinical Neurology 1997;0(06):-
Objective To explore the factors affecting the quality of life in patients with Parkinson's disease(PD).Methods The quality of life,severity of disease,activities of daily living,motor responses,mental state and the complications of treatment in 71 patients with PD were evaluated by the PD Quality of Life Questionnaire(PDQL),Unified PD Rating Scale(UPDRS),the Hoehn-Yahr scale,the Schwab and England disability scale,the Hamilton Depression Rating Scale for Depression(HRSD),and meanwhile factors such as age,gender,age of onset,the beginning symptom,the location of onset,smoking,doses of L-dopa and fluctuations etc were evaluated by some methods.Results Bivariate analysis showed that the longer course of disease and treatment,the more doses of L-dopa,the higher scores of UPDRS and the Hoehn-Yahr scale,and depression fluctuations with patients,the worse quality of life they had(P
5.Monitoring and evaluating of cerebral state index in the induction of anesthesia with targetcontrolled infusion with propofol and remifentanil
Xiaohong ZHAO ; Chengjie GAO ; Jian WANG ; Huixia WANG ; Jian LIU
Chinese Journal of Postgraduates of Medicine 2011;34(33):28-30
ObjectiveTo evaluate the accuracy of cerebral state index (CSI) as an indicator of anesthesia depth in the induction of anesthesia with target-controlled infusion (TCI) with propofol and remifentanil patients.Methods Forty-four ASA Ⅰ or Ⅱ patients undergoing elective surgery were anesthetized with TCI with propofol and remifentanil.Anesthesia was induced with TCI with remifentanil and propofol.The target effect-site concentration of remifentanil was 4 ng/ml.The initial effect-site concentration of propofol was 1.5 μ g/ml and was increased by0.5 μ g/ml every 4 min,till 1 min after the level of observer’s assessment of alertness sedation (OAA/S) score was 0 score.Electric tetanic stimulation was given when the level of OAA/S score was 1 score.The CSI,mean arterial pressure (MAP),heart rate (HR),OAA/S score and the effect-site concentration of propofol were recorded.ResultsCSI values declined with the decrease of OAA/S score,CSI was 91 ±5,77 ±7,70 ±7,62 ±6,49 ± 12,36 ± 10 at OAA/S score with 5,4,3,2,1score.CSI values were statistically different between 0 score and 1 score,1 score and 2 scores,3 scores and 4 scores,4 scores and 5 scores of OAA/S score(P <0.05).The differences of MAP,HR had no statistical significance between two scores of OAA/S score (P >0.05).The Spearman rank correlation coefficients between CSI,MAP,HR and OAA/S score were 0.899,0.342,0.125,respectively.The prediction probabilities to differentiate different OAA/S score for CSI,MAP,and HR were 0.89 ± 0.05,0.62 ± 0.08,0.53 ±:0.11,respectively.There was linear regression relationship between CSI and the effect-site concentration of propofol (the coefficient of determination was 0.812,P < 0.01 ).ConclusionDuring the induction of patients with TCI with propofol and remifentanil,the CSI is accurate as an indicator of awakening and different levels of consciousness after anesthesia,and can reliably predict the anesthesia depth.
6.An experimental study of difference of affective priming and attentional bias in young people
Chengjie YUAN ; Kai YU ; Weizhi LIU ; Zhilei SHANG
Chinese Mental Health Journal 2015;(5):378-382
Objective:To explore whether there will be attentional bias under the condition of fear,disgust and positive emotional arousal. Methods:Totally 96 college students were selected as participants in this study,inclu-ding 60 males and 36 femalesaged 18-22 years. Affective priming videos were adopted to prime participants'emo-tion (dread,disgust,joviality),and then they named the color of the cognitive words (positive words,negative words,neutral words)as quickly and accurately as possible. Reaction time and correctness were recorded. E-prime was adopted to write the experimental program. The reaction time for neutral words was baseline. Results:The aver-age reaction time (RT)of color-naming tasks of negative words were shorter than that of neutral words after fright-ening affective priming[(648 ±118)ms vs. (743 ±124)ms,P<0. 01]. Furthermore,the average RT of color-na-ming tasks of positive words were also shorter than that of neutral after frightening affective priming[(683 ±123) ms vs. (743 ±124)ms,P<0. 05]. The average RT of color-naming tasks of negative words were shorter than that of neutral words after disgusting affective priming[(579 ±86)ms vs. (720 ±101 )ms;P<0. 01 ]. Moreover,the av-erage RT of color-naming tasks of positive words were shorter than that of neutral words after delighted affective priming[(634 ±122)ms vs. (716 ±141)ms;P<0. 01]. Furthermore,the average RT of disgusting priming group-were shorter than the frightening priming grouptowards negative information[(579 ±86)ms vs. (648 ±118)ms,P<0. 05 ]. Conclusion:It suggests that the youth perform more obvious attentional bias towards negative information after disgusting affective priming than the frightening one. Frightening affective priming could evidently induce the attentional bias on positive information.
7.Observations on fatigue, depression and quality of life in patients with Parkinson's disease
Chengjie MAO ; Lidan CAO ; Qing TANG ; Chunfeng LIU
Chinese Journal of Internal Medicine 2013;(3):200-202
Objective To identify the association between fatigue and depression in Parkinson's disease(PD).Methods 56 PD patients were enrolled in this study.The degree of fatigue was measured by Fatigue Severity Scale (FSS).Hamilton Depression Scale (24 items) was used to evaluate the degree of depression.PD Quality of Life Questionnaire (PDQL) were tested to evaluate the quality of life in PD patients.While other clinical information such as Unified Parkinson's Disease Rating Scale (UPDRS) Ⅲ,Hoehn-Yahr Scale and modified Webster Scale were investigated.Results The incidence of fatigue in this group is 71.4% (40/56).Score of HAMD and PDQL exhibited a significant correlation to patients' fatigue,coefficient of partial correlation was 0.451 (P < 0.01),-0.346 (P < 0.05).The incidence of fatigue in non-depressive patients was low,27.3 %.While in depressive patients,the incidence of fatigue is relatively high,for mild depression 75%,moderate depression 100%,severe depression 100% respectively.Conclusions Fatigue is a prominent symptom of depression in PD patients,sometimes independent of depression also influencing the patients' quality of life.
8.Pretreatment with butorphanol to prevent injection pain of rocuronium bromide
Xiaohong ZHAO ; Chengjie GAO ; Jian WANG ; Huixia WANG ; Jian LIU
Chinese Journal of Postgraduates of Medicine 2011;34(36):17-19
Objective To evaluate the effect of pretreatment with butorphanol to prevent injection pain of rocuronium bromide.Methods One hundred and fifty ASA Ⅰ-Ⅱ grade patients,undergoing elective surgery were divided into 3 groups by random digits table with 50 cases each.Butorphanol group received butorphanol 2 mg,fentanyl group received fentanyl 100 μg,and control group received 0.9%sodium chloride when general anesthesia induced.Anesthesia was induced with propofol 2 mg/kg and the test drug was injected over 30 s,120 s after the test drug injection,1% rocuronium bromide 0.6 mg/kg was injected.Nausea,vomiting,apnea and bucking were recorded after drugs injection.Results The rates of rocuronium bromide injection pain in fentanyl group[10%(5/50)]and butorphanol group[8%(4/50)]were significant lower than that in control group[82%(41/50)](P < 0.01).None of the patients discovered nausea,vomiting,apnea and bucking in 3 groups.Conclusion Pretreatment with 2 mg butorphanol reduced the incidence of rocuronium bromide injection pain,furthermore,there is no untoward reaction such as nausea,vomiting,apnea and bucking.
9.Comparision of Partially and Totally Depolarization of Peripheral Nerve in Total Knee Arthroplasty
Wanjun CAO ; Shaoling ZHU ; Xiandong LIU ; Chengjie TANG ; Jinwen ZHENG ; Xingyu CHEN ; Ying LIU ; Peng XIAO
Chinese Journal of Rehabilitation Theory and Practice 2015;21(8):957-959
Objective To compare the effects of peripatellar peripheral nerve partially and totally depolarized in total knee arthroplasty (TKA). Methods 66 TKA patients were divided into partially depolarized group (A, 42 knees) and totally depolarized group (B, 38 knees). The scores of knee-joint, Feller and Visual Analogue Scale were recorded. Results There was no significant difference in all the scores between 2 groups before operation (P>0.05). All the scores improved after operation (P<0.05), however, there was still no significant difference between 2 groups (P>0.05). Conclusion Patellar peripheral nerve partially depolarization technique can reduce postoperative knee pain, which has the same effect with totally depolarization.
10.Clinical study on non-motor symptoms of essential tremor
Ping ZHANG ; Weidong HU ; Chengjie MAO ; Jianfang LIU ; Juping CHEN ; Chunfeng LIU
Chinese Journal of Neurology 2010;43(2):106-109
Objective To survey the prevalence, distribution of non-motor symptoms (NMS) in essential tremor (ET) and the relationship with disease severity and duration.Methods Fahn-Tolosa-Matin Tremor Rating Scale (TRS) was used to assess motor symptoms in 62 patients with ET.The Parkinson's disease (PD) NMS Questionnaire and T&T olfacmeter and Mini-mental State Examination (MMSE) were used to explore non-motor symptoms in ET patients.Results In ET, a range of NMS occurred across all disease stages.More than half patients (51.6%, 32/62) had olfactory dysfunction,significantly higher than the healthy control group (30.0%, 18/60, x~2=12.371, P<0.05).A third had hyposmia.16.1% had partial olfactory loss.Each ET patient had 5 different NMS on average.Seven NMS were more common in ET patients than in control, including remembering, olfactory dysfunction, intense vivid dreams, anhedonia, depression, anxiety, sleep disorders.The incidences of remembering, olfactory dysfunction,intense vivid dreams were 58.1% (36/62),51.6% (32/62),48.4% (30/62), ranked top 3 in ET patients.Olfaction had inverse correlation with age, while there was a negative correlation between NMS score and TRS score, gender, disease duration and weather to be treated.Conclusion Besides posture tremor and kinetic tremor,NMS occur in ET,and should be well recognized and treated.