Objective To explore the effect of hydrocolloid dressing on nasal continuous positive airway pressure(N-CPAP)?Methods Five hundred newborns in our hospital from January 2011 to December 2012 undergoing N-CPAP were randomly divided equally into the control group and the observation group? In the former,rhinobyon was used but it was loosen every 1 to 2 hours so that the local skin was kneadvation? In the observetion group,the hand-cut hydrocolloid dressing was used to prevent complications? The two groups were compared in terms of the incidence of skin complications and the satisfaction degree from their families? Result During N-CPAP,the observation group was significantly better in the incidence of skin complications and the satisfaction degree than the control group(all P < 0?05)? Conclusion Hydrocolloid dressing during N-CPAP has better efficacy in reducing the complication of the perirhinal skin?