Objective:To explore the personality types and the features of clinical subtypes of obsessive-compulsive disorder (OCD). Methods:82 cases of OCD were tested using Chinese MMPI that was revised by MMPI normative cooperative group. We used MMPI-B auto-analysis system made by Ji Shumao et al to calculate the basis scores and T scores of 73 scales.Results:Basis scores (+K)of scales F,Hs,D,Hy,Pd,Pa,Pt,Sc,(males and females)and Si,Mf(males) and K (females) on OCD group were higher that the scores of the normal group. The two-point code of T scores in OCD was 72/27.The factor analysis in 13 scales showed that there were four personality factors in OCD: neuroticism factor (Hs,Hy,D,Pt), psychotic factor(F,Pd,Sc),suspicious factor( F,Ma,Pa), Social introversion factor (L,Si,Mf).82 cases of OCD were divided into three groups by K-means of quick cluster analysis,T scores of 73 MMPI scales were different among three groups ( P

Objective To detect the genetic association between schizophrenia and rs1042724,rs384470 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene. Methods Observed in a sample of 98 parent/offspring trios where the proband net the American Classification and diagnostic Criteria for Mental Disorders. The Forth Revised Edition, criteria for schizophrenia using transmission/disequilibrium test(TDT) analysis. The polymorphism of nicotine-like acetylcholinergic receptor gene was detected with PCR methods and SNP typing in all nucleus families. Results Using a family-based association design we obtained evidence of an association between schizophrenia and allele of the rs1042724 polymorphism in the nicotine-like acetylcholinergic receptor gene(RR=1.31,2 (RR)=3.96,P＜0.05). Moreover the fact that transmission disequilibrium was observed when one affected offspring was selected at random from each family, suggesting that the results are due to association(McNemar 2 = 4.21,P＜0.05). There is no association between schizophrenia and rs1042724 polymorphism in the nicotine-like acetylcholinergic receptor gene (McNemar 2 =2.34,P＞0.05). Conclusion It shows an association between schizophrenia and the rs1042724 polymorphism at nucleotide of the nicotine-like acetylcholinergic receptor gene in Chinese.

Objective To investigate the association of the polymorphism of serotonin transporter gene linked polymorphic(5-HTTLPR) region with depression and its clinical symptoms in the Han Chinese.Methods PCR-based technique was used to genotype 5-HTTLPR in 64 patients with major depression and 67 unrelated controls,and the association between the polymorphism and clinical symptoms of depression was explored according to HAMD score.Results Fewer patients tended to be of L/L genotype(9.4%) than controls(19.4%),but there was no significant difference.Among women,fewer patients tended to be of L/L genotype(2.9%) than controls(13.9%),but there was no significant difference.The symptom analysis showed that depressive symptoms were significantly associated with 5-HTTLPR genotypes or alleles in the patients of L/L genotype,and that L allele had significantly lower depressive scores compared with those of other genotypes or alleles(P

Objective To explore the relationship between parental rearing behavior and the depressive disorders in adolescents,and to provide objective basis for the prevention and treatment of the depressive disorders.Methods A total of 73 depressed patients were chosen as the disease group,with a control group of 81 healthy persons of similar age,sex,education level and civil status.The depressed patient must meet depressive episode unipolar criteria and HAMD scores were more than 18.Results In males,the scores of father penalty and rejection factors and mother emotional warmth,and over-protection and over-involvement factors were significantly different from those in the control normal group.In females,the scores of father emotional warmth and penalty and rejection factors and mother emotional warmth and rejection factors were significantly different from those in the control normal group.Conclusion Parental rearing behavior plays an important role in the etiology of depression in adolescents.

Objestive:To explore the personality traits of patients with major depression and dysthymic disorder in remission and to determine the difference of dimension ,trait level ,model of personality and personality disorder between depressive and normal subjects.Methods: major depression patients( MDD, n =58) and dysthymic disorder patients(DD, n =57) in remission and controls( n =115) were assessed with Revised NEO Personality Inventory(NEO-PI-R) and Personality Diagnostic Questionnaire( PDQ +4 ) .Results:The mean scores of Extroversion and Conscientiousness of five-factor personality model of NEO-PI-R in MDD and DD were significantly lower than those of normal group. The scores of Neuroticism of DD were significantly higher than those of MDD. The scores of Agreeableness of MDD were significantly higher than those of normal groups;The difference of thirty traits personality model had statistical significance between depressives and normal subjects. The scores of Anxiety(N1) and Self-Consciousness(N4)of DD were significantly higher than those of MDD. The scores of Activity(E4) and Trust(A1)of DD were significantly lower than those of MDD;The mean scores of 7 subscales of PDQ +4 in depression group were significantly higher than those of normal group . The scores of Schizotypal personality disorder of DD were significantly higher than those of MDD, The scores of Hysteria personality disorder of DD were significantly higher than those of normal group.Conclusion: The major depressive and dysthymic disorder patients in remission showed the differences of dimension ,trait level ,and model of personality.The personality disorder of DD was more than those of MDD.

Objective To explore the association among the depression,symptom phnotypes and polymorphism TPH A218C in the Han Chinese.Methods TPH A218C was determined using a PCR-based technique.TPH was genotyped using restriction fragment length polymorphism in 70 patients affected by depression and 70 unrelated controls.We evaluated the symptom phenotypes of cases applying the Hamilton Rating Scale for depression(HAMD). Results The TPH A218C genotype distribution in 70 patients with major depression was significantly different from that in controls(?2=6.946,P=0.031).The C allele in patients(44.3%) was significantly more frequent than in controls(24.3%) but the A allele(55.7%) and A/A genotype(31.4%) were significantly less frequent than in controls(75.7% and 62.9%)(?2=6.946,P=0.031).Meanwhile,among the males,a trend was observed toward an excess of TPH C/C(12.5% vs.6.3%) in patients and excess of TPH A/A in controls(75.0% vs.25.0%)(?2=8.103,P=0.017).There were no significant differences in three genotypes distribution among symptom phenotypes of cases.Conclusion There was an association between TPH A218C polymorphism and depression.The findings raise the possibility that TPH A218C polymorphism may exert differential effects based on gender.There is no association among TPH A218C polymorphism and symptom phenotypes of depression.

Objective:To explore the personality types a nd the features of clinical subtypes of obsessive-compulsive disorder (OCD). Methods:82 cases of OCD were tested using Chinese MMPI that w as revised by MMPI normative cooperative group. We used MMPI-B auto-analysis sys tem made by Ji Shumao et al to calculate the basis scores and T scores of 73 sca les.Results:Basis scores (+K)of scales F,Hs,D,Hy,P d,Pa,Pt,Sc,(males and females)and Si,Mf(males) and K (females) on OCD group were higher that the scores of the normal group. The two-point code of T scores in O CD was 72/27.The factor analysis in 13 scales showed that there were fo ur personality factors in OCD: neuroticism factor (Hs,Hy,D,Pt), psychotic factor (F,Pd,Sc),suspicious factor( F,Ma,Pa), Social introvers ion factor (L,Si,Mf).82 cases of OCD were divided into three groups by K-means o f quick cluster analysis,T scores of 73 MMPI scale s were different among three groups (P<0.000).Conclusio n:The ps ychological features a nd comorbidity and responses to psychotherapy of three groups OCD are different.

Objective To explore the personality characters of patients with mental disorders and to determine the differences of dimension,trait level and model of personality between patients and normal subjects.Methods The patients with mental disorders(n=376) and normal subjects(n=368) were assessed with revised NEO personality inventory(NEO-PI-R).Results The mean scores of extroversion(E) and conscientiousness(C) of five-factor personality model of NEO-PI-R in patients were significant lower than those in normal group((P

Objective To explore the contribution of psychoso cial factors including personality and social support to the onset of upper dige stive tract cancer. Methods Ninety-eight patients with up per digestive tract cancer were chosen as disease group, with 98 healthy persons as control group, who matched with disease group in habitation, age, sex and ed ucation level. Both the two groups were studied by Eysenck Personality Questionn aire (EPQ) and social support scale. The differences between the two groups were analyzed. Results The E score of EPQ in disease group was lower than that in control group, but its P and L scores were higher, and the su pport utilization degree in disease group was much lower than that in control gr oup. Positive correlation was found between the E score of EPQ and social suppor t utilization degree in disease group. Conclusion The onset of upper digestive tract cancer is correlated with personality and social suppo rt.

Objective To explore the effects of psychosocial f actors including life events and coping style on the onset of upper digestive tr act cancer. Methods A total of 98 patients with upper diges tive tract cancer were chosen as experiment group, while 98 healthy persons were chosen as control group, who matched with experiment group in habits, age, sex and education background. Both the two groups were studied by Life Event Scale a nd Simplified Coping Style Questionnaire. The difference between the contributio n of psychosocial factors in the two groups was analyzed. Results The stimulating amount and frequency of negative life events in experimen t group were much higher than those in control group, while those of its positiv e life events were much lower. The total score of passive coping style in experi ment group was higher than that in control group, while the total score of posit ive coping style was lower. Conclusion Stress may be one of the etiological factors in causing upper digestive tract cancer, and passive co ping style may also be a risk factor for the etiology of upper digestive tract c ancer.