1.The Effect of Hypertriglyceridemia on Vascular Endothelial Function
Yun HUANG ; Guizhu DAI ; Zongchen FENG ; Chengfa LU ; Bei CHENG ; Qiufen WANG ; Fuding NIE ; Jingdong LI
Chinese Journal of Hypertension 2004;12(2):120-122
Objective To investigate the effect of hypert riglyceridemia on vascular endothelial function. Methods With high-resolution ultrasound, flow and nitroglycerin-induced dilatation of the brachial artery were determined in thirty hypertriglyceridemic patients and thirty healthy subjects as controls. Serum lipid and plasma endothelin (ET) were determined. Results In patients with hypertriglyceridemia,flow-induced vasodilatation was much reduced compared with that in the control subjects[(2.7±2.0)% vs (15.0±8.0)%, P<0.001].However, vasodilatation in response to nitroglycerin were similar in both groups[(15.0±5.0)% vs (16.8±9.0)%, P>0.05].Plasma ET level in the hypertriglyceridemic group was significantly higher than that in the control group[(106.22±19.16) μg/L vs (72.37±14.06) μg/L, P<0.001].ConclusionEndothelium-dependent vasodilatation was impaired in patients with hypertriglyceridemia.
2.Quantitative color Doppler sonography assessment of the blood flow in renal cortex in patients with systemic lupus erythematosus
Yuyuan CHEN ; Yanrong ZHANG ; Xinfang WANG ; Mingxing XIE ; Qing LV ; Tianwei YAN ; Chengfa LU ; Weifen LI ; Feixiang XIANG ; Yingying LIU
Chinese Journal of Interventional Imaging and Therapy 2009;6(4):359-362
Objective To assess the value of quantitative color Doppler sonography in patients with systemic lupus erythematosus (SLE). Methods The right renal in 21 patients with SLE and 22 normal subjects were examined with Philips IU22 ultrasonic diagnostic device. Resistence index (RI) of interlobar artery and interlobular artery were measured with color Doppler sonography, vascularity index (VI), flow index (FI) and vascularization flow index (VFI) which reflecting the renal cortical blood flow were calculated with quantitated analysis software. All the parameters between two groups were compared and analyzed. Results The color signals of renal cortical blood flow in patients with SLE were inferior to those of the normal group, especially in the area near the edge of renal. No statistical difference of RI was found between the two groups (P>0.05), while VI, FI and VFI in SLE group were significantly lower than those of the normal group (VI, VFI, P<0.01, FI, P=0.01). Conclusion Color Doppler sonography combined with blood flow quantitative technique provide a helpful, sensitive and convenient tool to detecte the renal changes in SLE patients.
3.Application of wave intensity technique on assessing hemodynamic changes in hyperthyroidism
Meiling WANG ; Yanrong ZHANG ; Qing Lü ; Mingxing XIE ; Yehua YIN ; Chengfa LU ; Tianwei YAN ; Yan HUANG ; Feixiang XIANG
Chinese Journal of Ultrasonography 2009;18(8):675-679
lusions WI parameters reflect both cardiac and vascular changes of hyperthyroid patients. Mid-systolic hemodynamic turbulence appears in a portion of hyperthyroid patients.
4.Wave intensity analysis of carotid artery: A noninvasive technique for assessing hemodynamic changes of hyperthyroid patients.
Yanrong, ZHANG ; Manwei, LIU ; Meiling, WANG ; Li, ZHANG ; Qing, LV ; Mingxing, XIE ; Feixiang, XIANG ; Qian, FU ; Yehua, YIN ; Chengfa, LU ; Tianwei, YAN ; Yan, HUANG
Journal of Huazhong University of Science and Technology (Medical Sciences) 2010;30(5):672-7
This study examined the wave intensity (WI) of the carotid artery in patients with hyperthyroid in order to assess the hemodynamic changes of hyperthyroid patients. A total of 86 hyperthyroid patients without cardiac morphological changes and arrhythmia, and 80 healthy control subjects were enrolled in the study. Right common carotid artery (RCCA) was selected for ultrasonic imaging to obtain WI indices, including amplitude of the peak during early systole (W1), amplitude of the peak during late systole (W2), area of the negative wave during mid-systole (NA), interval between R wave of electrocardiogram and W1 (R-1st), interval between W1 and W2 (1st-2nd). The levels of serum thyroid hormones, consisting of free triiodothyronine (FT3), free thyroxin (FT4) and thyroid stimulating hormone (TSH), were measured in hyperthyroid patients. Echocardiographic indices including left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) were determined in each subject. The results showed that the W1, W2, NA, and (1st-2nd×HR) in hyperthyroid patients were significantly higher than those in healthy controls. There was no significant difference in LVEF and LVFS between the two groups. FT3 was correlated with W1, W2, NA, (1st-2nd×HR), pulse pressure (PP) and heart rate (HR) in hyperthyroid patients. Several abnormal waves on WI curves were present in 19 hyperthyroid patients during mid-systole. It was concluded that WI technique may prove a real-time, noninvasive, sensitive and convenient tool for assessing the cardiac function and hemodynamic alterations in hyperthyroid patients.
5.Early Detection of Lesions of Dorsal Artery of Foot in Patients with Type 2 Diabetes Mellitus by High-frequency Ultrasonography
ZHANG YANRONG ; LI WENJING ; YAN TIANWEI ; LU CHENGFA ; ZHOU XIANG ; HUANG YAN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2009;29(3):387-390
lerosis of the lower extremity artery in patients with type 2 MD.
6.Effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
Yun HUANG ; Guizhu DAI ; Zongchen FENG ; Chengfa LU ; Bei CHENG ; Qiufen WANG ; Fuding NIE ; Jingdong LI
Chinese Medical Journal 2003;116(11):1767-1769
OBJECTIVETo investigate the effect of micronized fenofibrate on vascular endothelial function in patients with hypertriglyceridemia.
METHODSUsing high-resolution ultrasound, we measured flow- and nitroglycerin-induced dilatation of the brachial artery in 30 patients with hypertriglyceridemia before and after treatment with micronized fenofibrate at a dose of 200 mg once daily for 4 weeks. Simultaneously, both serum lipid and plasma endothelin (ET) levels were determined.
RESULTSAfter micronized fenofibrate therapy, serum triglyceride (TG) levels decreased significantly (P < 0.05). Plasma ET levels also decreased markedly [(82.66 +/- 15.46) microg/L vs. (106.22 +/- 19.16) microg/L, P < 0.001]. Flow-induced vasodilatation was much improved (11.0% +/- 9.0% vs 2.7% +/- 2.0%, P < 0.01). However, no significant changes in vasodilatation occurred in response to nitroglycerin (16.2% +/- 6.0% vs 15.0% +/- 5.0%, P > 0.05) in patients with hypertriglyceridemia.
CONCLUSIONSMicronized fenofibrate can improve impaired endothelium-dependent vasodilatation in patients with hypertriglyceridemia. Improving endothelial function may also be the mechanism responsible for the beneficial effects of micronized fenofibrate.
Adult ; Endothelium, Vascular ; drug effects ; physiology ; Female ; Fenofibrate ; pharmacology ; therapeutic use ; Humans ; Hypertriglyceridemia ; drug therapy ; Male ; Middle Aged ; Vasodilation ; drug effects
7.Wave Intensity Analysis of Carotid Artery: A Noninvasive Technique for Assessing Hemodynamic Changes of Hyperthyroid Patients
ZHANG YANRONG ; LIU MANWEI ; WANG MEILING ; ZHANG LI ; LV QING ; XIE MINGXING ; XIANG FEIXIANG ; FU QIAN ; YIN YEHUA ; LU CHENGFA ; YAN TIANWEI ; HUANG YAN
Journal of Huazhong University of Science and Technology (Medical Sciences) 2010;30(5):672-677
This study examined the wave intensity (WI) of the carotid artery in patients with hyperthyroid in order to assess the hemodynamic changes of hyperthyroid patients. A total of 86 hyperthyroid patients without cardiac morphological changes and arrhythmia, and 80 healthy control subjects were enrolled in the study. Right common carotid artery (RCCA) was selected for ultrasonic imaging to obtain WI indices, including amplitude of the peak during early systole (W1), amplitude of the peak during late systole (W2), area of the negative wave during mid-systole (NA), interval between R wave of electrocardiogram and W1 (R-1 st), interval between W1 and W2 (1 st-2nd). The levels of serum thyroid hormones, consisting of free triiodothyronine (FT3), free thyroxin (FT4) and thyroid stimulating hormone (TSH), were measured in hyperthyroid patients. Echocardiographic indices including left ventricular ejection fraction (LVEF) and left ventricular fraction shortening (LVFS) were determined in each subject. The results showed that the WI, W2, NA, and (lst-2nd×HR) in hyperthyroid patients were significantly higher than those in healthy controls. There was no significant difference in LVEF and LVFS between the two groups. FT3 was correlated with WI, W2, NA,(lst-2nd×HR), pulse pressure (PP) and heart rate (HR) in hyperthyroid patients. Several abnormal waves on WI curves were present in 19 hyperthyroid patients during mid-systole. It was concluded that WI technique may prove a real-time, noninvasive, sensitive and convenient tool for assessing the cardiac function and hemodynamic alterations in hyperthyroid patients.