1.Survey on the levels of high density lipoprotein and low density lipoprotein among the staff in a college
Minghui XIA ; Haiqin TANG ; Chengcheng TONG
Chinese Journal of Primary Medicine and Pharmacy 2014;(15):2251-2252
Objective To analyze the levels of high density lipoprotein ( HDL) and low density lipoprotein ( LDL) among the staff in a college .Methods Fasting serum samples were collected from 2 234 paticipants .The lev-els of HDL and LDL in different sex and ages were estimated .Results The average value and abnormal rate of LDL in males were 3.20mmol/L and 49.1%,respectively.The average value of LDL in males was higher than normal val-ue.The average value and abnormal rate of LDL in females were 3.03mmol/L and 42.3%,respectively.The value of LDL in females who less than 54 years old was lower than that in males of the same age ( t=5.33,10.56,all P<0.01).Conclusion The abnormal rate of LDL had significant increase and the level in males was higher than that in females.The health education is necessary to prevent and control the abnormal level of LDL .
2.Image processing system of visual prostheses based on digital signal processor DM642.
Chengcheng XIE ; Yanyu LU ; Yun GU ; Jing WANG ; Xinyu CHAI
Chinese Journal of Medical Instrumentation 2011;35(5):330-334
This paper employed a DSP platform to create the real-time and portable image processing system, and introduced a series of commonly used algorithms for visual prostheses. The results of performance evaluation revealed that this platform could afford image processing algorithms to be executed in real time.
Algorithms
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Image Processing, Computer-Assisted
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instrumentation
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methods
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Signal Processing, Computer-Assisted
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instrumentation
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Visual Prosthesis
3.Homing and characteristic analysis of macrophage in immune-mediated aplastic anemia model mice
Wei SUN ; Zenghua LIN ; Han WANG ; Hui JIA ; Laigen TONG ; Zhipeng ZHANG ; Wen LI ; Chengcheng ZHOU ; Hong LIU
Chinese Journal of Hematology 2024;45(6):594-598
To investigate the dynamic homing process and characteristics of macrophages in different organs of immune-mediated aplastic anemia (AA) model mice. Macrophages in donor lymph nodes were sorted by magnetic beads and labeled with PKH67. After modeling according to the preparation method of the AA model, peripheral blood rountine analysis, bone marrow biopsy and HE staining results were analyzed to verify the modeling effect. On days 4, 8, and 12 of modeling, the bone marrow, spleen, and lymph node mononuclear cells were collected, and dynamic changes of PKH67-labeled macrophages in donor mice were analyzed by flow cytometry. In this study, dynamic changes in PKH67-labeled macrophages in the pathogenesis of AA model mice were explored. Macrophages in donor mice homed to the lymph nodes, expanding and differentiating in the lymph nodes, and finally transported to the bone marrow and spleen. Through proteomics mass spectrometry analysis, the related immune inflammatory response pathway of macrophages involved in the activation of the AA bone marrow microenvironment was preliminarily revealed, which provides a basis for the pathological macrophages involved in the pathogenesis of AA model mice.
4.Study on Main Treatment Diseases and Medication Rule in Sichuan Nanpai Tibetan Medicine Based on Data Mining
Chengcheng ZHAO ; Tong XU ; Meigui TIAN ; Huan DU ; Gang FAN ; Yi ZHANG
China Pharmacy 2019;30(19):2662-2667
OBJECTIVE: To study the academic characteristics and connotation of Sichuan Nanpai Tibetan medicine (SNTM), to provide relevant information for the inheritance and development of Nanpai Tibetan medicine, and to provide reference for the development and utilization of commonly used medicinal materials in SNTM. METHODS: The type characteristics, medication frequency, main treatment disease and medication rule of 672 preparations of Tibetan hospital of SNTM were analyzed by means of data mining, statistical analysis and inductive deduction methods of TCM inheritance support system (TCMISS). Based on the core combination drugs, the new prescriptions were evolved by the entropy hierarchical clustering method. RESULTS: A total of 624 medicinal materials were used in formulation of SNTM, involving 509 plant drugs (81.67%), 61 mineral drugs (9.77%) and 54 animal drugs (8.65%). There were 16 medicines with frequency>120; among them, top 3 medicines were Terminalia chebula (57.44%), Carthamus tinctorius (43.15%) and Aucklandia lappa (42.26%). Main treatment diseases involved 13 categories, and top 3 categories were gastric diseases (28.13%), hepatobiliary diseases (12.80%) and neurological diseases (11.90%). In the treatment of stomach diseases, T. chebula, C. tinctorius, Alpinia katsumadai, Piper longum, A. lappa and Punica granatum were mainly used; totally 61 commonly used drug combinations were obtained and the most commonly used combination was P. longum-A. katsumadai. In the treatment of hepatobiliary diseases, T. chebula, C. tinctorius, Herpetospermum caudigerum, Swertia bimaculata, Zhaxun were mainly used; 64 commonly used drug combinations were obtained and the most commonly used combination is T. chebula-C. tinctorius. In the treatment of neurological diseases, Myristica fragrans, T. chebula, A. lappa, Syzygium aromaticum, Aquilaria sinensis, Choerospondias axillaris were mainly used; 73 commonly used drug combinations were obtained, and the most commonly used combination was T. chebula-M. fragrans. 5 candidate new formulations had been evolved by the entropy hierarchical clustering method, involving Lacciferlacca-Lithospermum erythrorhizon-Rubia cordifolia- Punica granatum. CONCLUSIONS: Obtained high frequency drug pairs and evolved new candidate formulation based on the core combinations drugs of SNTM for commonly diseases can provide reference for the development of modern new Tibetan medicines for gastric, hepatobiliary and neurological diseases.