Objective To explore the characteristics of the bus explosion wounds and their first aid and treatment. Methods The conditions of the 87 victims of two bus explosions and their treatments were analyzed retrospectively. Results Of the 87 victims, 9 died on the spot, 3 died on their way to the hospital, 18 were treated in the outpatient department and discharged after observation for several days, and 57 received hospitalization treatment. All the patients were discharged with full recovery except that 2 with bone defects in 3 limbs had to receive secondary bone transplantation and 2 with tibial nerve injury had to receive secondary nerve plerosis. Conclusions The conditions of victims of the bus explosion are usually severe and complicated. The majority of the patients present compound wounds with high mortality. Pre hospital first aid and classification of the patients should be made properly before the patients are referred to the hospital in batches. Treatment should be arranged in order of severity and urgency.