Objective To investigate the correlation of intima-media thickness (IMT) of the lower peripheral arteries and maximal shear rate (SR) in diabetic (DM) patients and to analyze the related risk factors.Methods A total of 84 diabetic patients and 46 controls were recruited in the study.Color Doppler ultrasonography technique was applied to observe the IMT,diameter(D) and hemodynamics of the lower peripheral arteries and the comparison with biochemical parameters was carried out in order to reveal their correlation to the pathological changes of vascular in DM patients.ResultsIn DM group,the SR was lower than that in control group (P＜0.05).The risk factors related to the lower peripheral arteries of DM patients also were significant difference to that of control group (P＜0.05).Conclusion The decrease of SR in diabetes patients can cause the thicker IMT,which is one of the important factors leading to atherosclerosis and is correlated to various risk factors for metabolic syndrome.

AIM: To establish a method of determining the content of total saponin of Radix et Rhizoma Notoginseng in buccal tablets by HPLC. METHODS: Chromatographic conditions are as follows:Hypersil NH_2 column(4.6 mm?200 mm,5 ?m) as the stationary phase,acetonitrile-1% phosphate buffer solution(0-10 min,20:80;10-20 min,25:75;20-25 min,45:55;25-30 min,50:50) as the mobile phase,the velocity of flow is 1.0 mL/min,the temperature of coloum is 35(?C) and the detection wavelength is 203 nm. RESULTS: The HPLC method has good linearity in determining the total saponin of Radix et Rhizoma Notoginseng content,and we can detect four saponins at the same time,linear range,ginsenoside Rg1 0.093 75-6 ?g,ginsenoside Re 0.011 72-0.75 ?g,notoginsenoside R1 0.023 44-1.5 ?g and ginsenoside Rb1 0.140 6-9 ?g,the correlation coefficient r=0.999 9. CONCLUSION: The established method in this article is simple and convenient,with good reproductivity.We can detect four saponins in the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets at the same time by this method.It can be used for quality control of the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets.

To elucidate the academic thought of Professor ZHOU Zhong-ying about cancerous toxin. Professor Zhou holds that the cancerous toxin,a toxic pathogen occurring during the occurrence and development of malignant tumor,is the key for occurrence of malignant tumor. The compound pathogeneses of malignant tumor are the coexistence,reciprocal causation,combination and transformation between the cancerous toxin and the pathological factors of phlegm,blood stasis and dampness. Based on the theory of cancerous toxin,the therapeutic rules of malignant tumor should be removing carcinoma and eliminating toxin,supporting vital qi to eliminate pathogens,and combined the resolving phlegm,removing blood stasis,eliminating dampness or clearing away heat according to the different pathological factor accompanying,such as phlegm,blood stasis or dampness,etc.

Pancreatic cancer is one of the most lethal human malignant tumors, and its incidence is rising. Now, its treatment includes surgical resection,chemo - radiotherapy and supplementary treatment. The prognosis of pan-creatic cancer is still dismal. And its one-year survival is low. This article talks about the effect of clinical treatment on quality of life in patients with pancreatic cancer.

Objective To test the safety and efficacy of using Botulinum Toxin Type A(BTX-A)in the treatment of chronic daily headache(CDH). Methods Thirty-eight patients in the treatment group injected BTX-A 50 U at 10 positions at the muscles including frontalis, temporalis, splenius capitis and occipitalis. Forty-four patients in the control group were given 2% lidocaine 3 ml plus prednisolone acetate 75 mg(2 ml)at the same muscles sites as in the treatment group. Frequency of headache, headache intensity(evaluated by visual analogue scale, VAS), quality of life(by WHO Qol-8 questionnaire)and adverse reactions were assessed on 0, 30, 60, 90 days after the treatment. Results At follow-up of 30,60, 90 days, the number of headache days per month reduced in both groups. BTX-A group had 14. 0 ±7.8, 13. 0 ±6. 8 and 13.0 ±6. 4 days per month, while the control group had 19. 0 ±6. 1, 21.0 ±6. 1 and 21.0 ±5.8, days at the follow-up of 30, 60 and 90 days, respectively, showing significant difference in the two groups(Z = 2. 895, 4. 544 and 4. 878, all P ＜ 0. 01). At 30 days, VAS scores in the treatment and control groups were 3.6 ± 1.5 and 3. 8 ± 1.3 respectively, showing no significant difference(Z = 1. 254,P =0. 210); At 60 days and 90 days, VAS scores in the BTX-A group were 3.2 ± 1.5 and 3. 1 ± 1.6 respectively, and in the control group were 4. 7 ± 1.3 and 5.0 ± 1.5 respectively, showing significant difference(Z =4. 950 and 5. 096, both P =0. 000). Quality of life in the two groups was slightly improved.After the treatment, 1 case(2. 6%)in BTX-A group occurred brow ptosis. The other patients didn't report any treatment related adverse events. Conclusion BTX-A is an effective and relative safe treatment in patients with CDH.

Eighty percent of unexplained syncope children can be diagnosed of vasovagal syncope (VVS). Positive head-up tilt test (HUTT) leads to the diagnosis of VVS. However,organical diseases which can cause syncope should be excluded before HUTT was taken. The therapies of VVS include nonpharmacological therapy (health education, head-up training, water and salt supplement), pharmacological therapy (β-blockers, α-receptor agonists, fludrocortisone, selective serotonin reuptake inhibitors, angiotension converting enzyme inhibitors, et al.) and pace maker.

Animals ; Disease Models, Animal ; Ischemic Preconditioning ; methods ; Lung ; blood supply ; Male ; Nitric Oxide Synthase ; metabolism ; Nitroarginine ; pharmacology ; Rabbits ; Reperfusion Injury ; metabolism

Objective To investigate the expression of PTEN and P 27 proteins in esophageal epitheliosis and carcinogenesis , and the relation to the development of esophageal carcinoma .Methods PTEN and P27 proteins ex-pression in 60 fresh tissue specimens , including esophageal mucosa above the upper surgical margin , carcinoma in si-tu and mucosa adjacent to tumor , were detected using immunohistochemical method .Results The expression of e-sophageal epithelial cells PTEN and P 27 proteins in normal , hyperplastic and malignant gradually decreased , which showed a similar distribution pattern in esophageal carcinogenesis .Conclusion Malignant transformation expression change of PTEN and P 27 proteins and esophageal mucosa are closely related , and the expression of PTEN and P 27 proteins deletion may be a biological marker useful and esophageal cancer early diagnosis index .

Objective To improve the health of women and children,we built a medical research platform with maternal and child health characteristics and feature.Methods Since January 2011,we build the medical research platform of Huaian MCH through the following three aspects.①To firmly establish the thought of Science and technology to revitalizing the hospital and outstand technical innovation.② built a medical research platform with maternal and child health characteristics and feature.③To focus on construction of Research platform.Results After building research platform,the total number of published papers or high-level papers and the total number or level of the Research Projects and the New Technology Award are significantly higher.Many disciplines and specialist technical levels have been improved in our MCH.Neonatal Medical Center and Children's Health Center have upgraded to Provincial Maternal and Child Healthcare key disciplines.The department of women healthcare has upgraded to Provincial Maternal and Child Healthcare key disciplines construction unit.In 2012,our MCH got top 30 of comprehensive index ranking in operation and development of the National Maternal and Child Health agencies.Conclusion Building the medical research platform with the characteristics of maternal and child healthcare,can improve maternal and child healthcare service quality and level of clinical services,and promote the development of the hospital's overall strength,thereby increasing the ability of hospitals to protect the health of women and children.

Objective To establish a diagnostic scoring system for diabetic patients with smear-negative pulmonary tuberculosis , and then to improve the rapidity and accuracy of clinical diagnosis and save medical expenses. Methods A case-control study was applied. 150 diabetic patients with smear-positive pulmonary tuberculosis who on initial treatment were assigned to a study group; 150 patients with lung infection were recruited as a study group. The data on general status, symptoms, chest X-ray manifestation, and laboratory examinations was collected. Univariate logistic regression analysis was used to gain significant indexes for multiple logistic regression analysis. β-coefficients derived from the independent predictors in our logistic regression model was applied to develop a scoring system. Results Toxic symptoms of tuberculosis, cough, upper lung, cavity, multiple lung field , and PPD positive entered into the final multipie logistic regression model , and the scoring system was accordingly established. The patient with a score of more than 11 had higher probability of TB , while those with a score of smaller than 11 were not likely to have TB. Conclusion The scoring system can be used as a predictive tool in diagnosis of diabetes mellitus complicated by smear-negative pulmonary tuberculosis , helping diagnose active tuberculosis rapidly.