Animals ; Disease Models, Animal ; Ischemic Preconditioning ; methods ; Lung ; blood supply ; Male ; Nitric Oxide Synthase ; metabolism ; Nitroarginine ; pharmacology ; Rabbits ; Reperfusion Injury ; metabolism

Objective To test the safety and efficacy of using Botulinum Toxin Type A(BTX-A)in the treatment of chronic daily headache(CDH). Methods Thirty-eight patients in the treatment group injected BTX-A 50 U at 10 positions at the muscles including frontalis, temporalis, splenius capitis and occipitalis. Forty-four patients in the control group were given 2% lidocaine 3 ml plus prednisolone acetate 75 mg(2 ml)at the same muscles sites as in the treatment group. Frequency of headache, headache intensity(evaluated by visual analogue scale, VAS), quality of life(by WHO Qol-8 questionnaire)and adverse reactions were assessed on 0, 30, 60, 90 days after the treatment. Results At follow-up of 30,60, 90 days, the number of headache days per month reduced in both groups. BTX-A group had 14. 0 ±7.8, 13. 0 ±6. 8 and 13.0 ±6. 4 days per month, while the control group had 19. 0 ±6. 1, 21.0 ±6. 1 and 21.0 ±5.8, days at the follow-up of 30, 60 and 90 days, respectively, showing significant difference in the two groups(Z = 2. 895, 4. 544 and 4. 878, all P ＜ 0. 01). At 30 days, VAS scores in the treatment and control groups were 3.6 ± 1.5 and 3. 8 ± 1.3 respectively, showing no significant difference(Z = 1. 254,P =0. 210); At 60 days and 90 days, VAS scores in the BTX-A group were 3.2 ± 1.5 and 3. 1 ± 1.6 respectively, and in the control group were 4. 7 ± 1.3 and 5.0 ± 1.5 respectively, showing significant difference(Z =4. 950 and 5. 096, both P =0. 000). Quality of life in the two groups was slightly improved.After the treatment, 1 case(2. 6%)in BTX-A group occurred brow ptosis. The other patients didn't report any treatment related adverse events. Conclusion BTX-A is an effective and relative safe treatment in patients with CDH.

Eighty percent of unexplained syncope children can be diagnosed of vasovagal syncope (VVS). Positive head-up tilt test (HUTT) leads to the diagnosis of VVS. However,organical diseases which can cause syncope should be excluded before HUTT was taken. The therapies of VVS include nonpharmacological therapy (health education, head-up training, water and salt supplement), pharmacological therapy (β-blockers, α-receptor agonists, fludrocortisone, selective serotonin reuptake inhibitors, angiotension converting enzyme inhibitors, et al.) and pace maker.

Pancreatic cancer is one of the most lethal human malignant tumors, and its incidence is rising. Now, its treatment includes surgical resection,chemo - radiotherapy and supplementary treatment. The prognosis of pan-creatic cancer is still dismal. And its one-year survival is low. This article talks about the effect of clinical treatment on quality of life in patients with pancreatic cancer.

Objective To investigate the correlation of intima-media thickness (IMT) of the lower peripheral arteries and maximal shear rate (SR) in diabetic (DM) patients and to analyze the related risk factors.Methods A total of 84 diabetic patients and 46 controls were recruited in the study.Color Doppler ultrasonography technique was applied to observe the IMT,diameter(D) and hemodynamics of the lower peripheral arteries and the comparison with biochemical parameters was carried out in order to reveal their correlation to the pathological changes of vascular in DM patients.ResultsIn DM group,the SR was lower than that in control group (P＜0.05).The risk factors related to the lower peripheral arteries of DM patients also were significant difference to that of control group (P＜0.05).Conclusion The decrease of SR in diabetes patients can cause the thicker IMT,which is one of the important factors leading to atherosclerosis and is correlated to various risk factors for metabolic syndrome.

Objective To explore the effect of aspirin resistance on cardiovascular events in non-insulin-dependent diabetes melli-tus patients .Methods 496 patients with non-insulin-dependent diabetes mellitus received daily aspirin therapy (100mg/d) 4 weeks were recruited from Jun .2006 to Sept .2010 .Platelet aggregation was measured by light transmission aggregometry .The patients were divided into three groups :aspirin resistance group ,aspirin semi-resistance group and aspirin-sensitive group .The clinical bio-chemistry indications and the adverse cardiovascular events were collected .Results 11 .69% of patients were found to be resistant to aspirin therapy ,and 37 .90% of patients to be aspirin semi-responders .There were 67 .48% female in aspirin resistance group and aspirin semi-responders .The preprandial glucose of group AR and ASR was higher than that of group AS (P<0 .05) .The HbA1C and TG of group AR were higher than those of group AS(P<0 .05) .There was statistically significant difference of the rate of car-diovascular events .Conclusion The measure of platelet aggregation should be taken in the diabetic mellitus patients and pay atten-tion on the dose of aspirin recommended .Particular attention is should also devote to the incidence of adverse cardiovascular events .

[Objective] Probe the source of Nv’ke Baixiao Quanshu or Obstetrics and Gynecology Pandect compiled by Gong Juzhong in Ming Dynasty, explorate the content and academic idea. [Methods]Through investigating and surveying the different editions, col ating and organizing the contents, probe and analyse the writing motivation, content and main idea of the work. [Results] The most contents of Nu ’ke Baixiao Quanshu are inherited from an-other work named Jiaozhu Furen Liangfang with 8 contents:Regulating the menstrual period, praying for children, antenatal training, previous preparation for delivery, parturition, lying-in, difficult labouring. The rest of the contents is extracted from some other works. This work records disease symptoms and medicine, surgery, gynecology and gravidity in various internal organs. Referring ancient classics on disease causes and researching prescriptions and treatments, the author emphasized naturalizing liver, kidney and spleen in warm. Mr. Gong applied drugs corresponding to syndromes. In the Qiusi and Taihou parts, he discussed rationales of infertility, natural endowment and pre-natal and post-natal care and introduced methodology of pulse feeling to diagnose pregnancy, Yuanfang Chao’s twelve col ateral channels in nourishing and training fetus, medicine conditioning for pregnant women, daily regi-men, medicine prohibition, preparation of ante partum. [Conclusion] Nu ’ke Baixiao Quanshu is created by extracting. Mr gong learned widely from oth-er’s strong points and compiled with distinct academic view, significantly guiding development of clinical medicine in department of gynecology of tradi-tional Chinese medical science and formation of system of reproduction care. Yet, some theories like methodologies of gender-oriented reproduction and gender-shifting reproduction should be discarded.

Objective:To study the impact of clinical pharmacy information management system on antimicrobial stewardship in a general teaching hospital. Methods:The main function, deficiencies and aspects needing improvement of clinical pharmacy information management system, and its influence on antimicrobial stewardship were introduced. Results:The information system had such functions as antimicrobial usage statistics, evaluation of antimicrobial prescription, and the use intensity calculation of antimicrobials. By using the information system, manpower of antimicrobial stewardship was saved, antimicrobial statistics became more comprehensive and objective, and dynamic real-time monitoring of antimicrobial drugs management was realized. However, the system still had some shortcomings needing improvement. Conclusion:Clinical pharmacy information system can promote the implementation and efficiency of antimicrobial stewardship.

AIM: To establish a method of determining the content of total saponin of Radix et Rhizoma Notoginseng in buccal tablets by HPLC. METHODS: Chromatographic conditions are as follows:Hypersil NH_2 column(4.6 mm?200 mm,5 ?m) as the stationary phase,acetonitrile-1% phosphate buffer solution(0-10 min,20:80;10-20 min,25:75;20-25 min,45:55;25-30 min,50:50) as the mobile phase,the velocity of flow is 1.0 mL/min,the temperature of coloum is 35(?C) and the detection wavelength is 203 nm. RESULTS: The HPLC method has good linearity in determining the total saponin of Radix et Rhizoma Notoginseng content,and we can detect four saponins at the same time,linear range,ginsenoside Rg1 0.093 75-6 ?g,ginsenoside Re 0.011 72-0.75 ?g,notoginsenoside R1 0.023 44-1.5 ?g and ginsenoside Rb1 0.140 6-9 ?g,the correlation coefficient r=0.999 9. CONCLUSION: The established method in this article is simple and convenient,with good reproductivity.We can detect four saponins in the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets at the same time by this method.It can be used for quality control of the total saponin of Radix et Rhizoma Notoginseng Buccal Tablets.

At present, there are the pheuomena of asking sor maney fram patients, writing out unnecessary prescription,and getting medicaine without payment among physicians. It is mot accord with the humanitarianism for patients imim China As everyone knows, the medical moraiith of health adimin'strative cadre involve that whether of not the quality of health services correspond to need of patients so, in this paper, the author discusses that how to strengthen the medical morality for health adimin's trative cadres.