Objective To understand the current status and the changes in main disability reasons in the elderly with physical disabilities during the past 20 years in China. Methods　The data of the elderly with physical disabilities aged 60 years and over that were from the national sample survey on disability in 1987 and 2006 were analyzed and compared by epidemiology methods. Results　In 2006.the main disability reasons in the elderly with physical disabilities aged 60 and over were disease factors,injury factors,other factors and congenital diseases and eccyliosis.The cause-specific disability prevalences were 5.262%,1.885%,1.000% and 0.200%respectively.Cerebrovaseular diseases showed the highest cause-specific disability prevalence of 2.552% in all the causes.Compared with the national sample survey in 1987,the cause-specific disability prevalences of disease factors and injury factors were obviously increased.The top five disability reasons in the elderly with physical disabilities aged 60 years and over in China were cerebrovascular diseases,arthropathy,miscellaneous traumas,other causes and unknown causes in the national sample survey in 2006;while vascular diseases,other traumas,other causes,unknown causes and pyogenic infection were the top five disability reasons in the national sample survey in 1987.The age-specific top five reasons were basically the same with the total top five disability reasons of the elderly with physical disabilities aged 60 years and over,and also the same relationship between sex-specific top five reasons and Iotal top five disability reasons in 1987 and 2006. Conclusions　Disease factors are the main disability reasons of the elderly with physical disabilities aged 60 years and over,and cerebrovascular diseases have the highest cause specific disability prevalence.The prevention and cure of cerebrovascular diseases,arthropathy and other traumas become the key points to prevent physical disability in the elderly.

Objective To study the main causes of hearing disability in Beijing residents. Methods The second national sample survey on disability of China was carried out in Beijing on April 1,2006. Muhiphase, stratified, proportional and cluster samplings were adopted to investigate 74 795 residents in Beijing, including 36 753 males and 38 042 females. 55 773 were urban residents while 19 022 from rural areas. The method of descriptive study was used to analyze the data of hearing disabitity in Beijing. Results Top five causes of hearing disability (including multiple disabilities) in Beijing were presbycusis, unknown, systematic diseases, noise induced, and odds media. The prevalence was 1.10%, 0.30%, 0.30%, 0.20% and 0.17%, respectively. Heredity, unknown and others were the main causes of children under 0～14 years. Unknown, ototoxicity, and otitis media were the main causes of people aged 15 ～59 years. Presbycusis, systematic diseases, noise induced and unknown were main causes of people aged 60 years and older. Presbycusis was the top cause of hearing disability for male and female residents as well as people live in urban and rural areas in Beijing. Conclusion Presbyeusis, unknown, systematic diseases, noise induced, and otitis media were main causes of hearing disability (including multiple disabilities) in Beijing.

Clinical significance of ovarian cancer marker COX 1 was studied . The data were colected from 97 cases of ovarian benign and malignant orarian tumors diagnosed by pathology . A sandwich enzyme immunoassay procedure was designed for quantitative determinations of COX 1, and CA125 was detected. 52 78% of COX 1 was found to be positive in ovarian cancer group ( P

To investigate the prognosis relevant factors of endometrial carcinoma. Clinical pathological materials of 68 cases of endometrial carcinoma were analyzed. The 5 year survival rate of ≥40 years old women with endometrial carcinoma was slightly less than that of the younger women, while menopause showed no influence on the survival rate .The 5 year survival rate of patients with term parity ≥2 was 92 7%( P 0 05). Therefore, surgical method ,clinical staging ,invasion depth of uterine muscle and number of term parity are the important factors which influence the prognosis of endometrial carcinoma.

Objective To explore the effects of ethyl pyruvate (EP) on hepatic high mobility group box-1 protein (HMGB1) expression in experimental routine with acute necrotizing pancreatitis (ANT). Method ANP model was induced by retrograde injection of 5 % sodium taurocholate into pancreatic duct. Twenty-four male wistar rats were divided randomly into 3 groups(8 rats in each group): group A (ANT group); group B (ANP rats re-ceived ethyl pyruvate therapy) and group C (control group with sham operation). The concentration of plasma amylase (AMY), A.sr and ALT, and the activity of myeloperoxidase (MPO) in the liver were determined. The ex-pression of HMGB1 mRNA in liver was detected by using reverse transcription polymerase chain reaction (RT-PCR). The changes of morphological damage were observed under microscopy. The expression of HMGB1 in the liver was observed by using SP immunohistochemistry. ANOVA was performed with SPSS 10.0 statistical analysis software and the difference was accepted as significant if the P<0.05, as verified by using Duncan's and Tukey' s post hoc test. Results Compared with gxoup A,levels of plasma AMY,AST and ALT in group B were markedly lower (P<0.05). Compared with group C, MPO in group A was higher significantly (P<0.01).with group A, the pathological changes of pancreas and liver in group B were milder. Compared with group C,the hepatic HMGB1 mRNA expression was markedly higher in group A [(0.28±0.04) vs. (0.73±0.06), P<0.01]. By contrast,the HMGB1 mRNA expression was markedly lower in group B compared with group A [(0.46±0.05) vs. (0.73±0.06), P<0.05]. The HMGB1 protein expression in hepatocytes and Kupffer's cells of rats with ANP was significantly up-regulated compared with control group, but it was reduced significantly in EP treatment group. Conclusions HMGB1 as a late mediator in liver might be involved in the pathogenesis of acute hepatic injury with ANP. EP could down-regulate the hepatic HMGB1 expression together with improvement of liver function in rats with ANP.

Objective:To investigate the relationship between high mobility group box-1 protein (HMGB1) expression and gut mucosal barrier dysfunction during murine severe acute pancreatitis (SAP). Methods:Forty-eight male health adult Wistar rats were divided randomly into Control group and SAP groups. The concentration of plasma D-lactate and the activity of myeloperoxidase (MPO) in the intestinal tissue were determined. The expression of HMGB1 mRNA in intestinal mucosa was detected by reverse transcription polymerase chain reaction (RT-PCR) and the activity of HMGB1 was determined by Western blot. Results:Plasma D-lactate and MPO reached a peak level at 24h (16.41?4.65)?g/mL for Plasma D-lactate and(26.76?3.63)U/g for MPO respectively, (P

Objective To evaluate the clinical and imaging characteristics of osteoid osteoma in femoral neck and to improve diagnostic accuracy of this disease.Methods Twenty-one patients (18 males and 3 females,age,7-26 years,median age,13 years) with pathologically proven osteoid osteoma of the femoral neck were retrospectively analyzed for their clinical profile and radiologic features.CT and X-ray examinations were performed in all patients,10 of them pefformed post-contrast CT scan and 4 of them performed MRI examinations.Results Nineteen patients had hip pain (pain worse at night in 11,and 8 received salicylates treatment with good response),and 2 patients only with intermittent claudication.The duration ranged from 2 months to 54 months (median duration 12 months).X-ray: Nidus was seen on plain film in 10 cases,18 cases showed different degrees of bone sclerosis of the nidus.CT: Nidus was demonstrated in all cases.Among them,8 were intracortical,6 were subperiosteal,7 were endosteal.Twenty cases showed different degrees of bone sclerosis of the nidus-extra-articular anteromedial cortical surface of the femur neck.Nineteen cases showed vascular groove sign.MRI: Nidus was seen in 4 cases.Bone sclerosis was low signal on all sequences.Three cases had joint effusion,4 cases had bone marrow edema,and 2 cases had synovial thickening.Conclusions Although osteoid osteoma of femoral neck has non-specific clinical features,the radiographic findings are usually typical.The nidus of osteoid osteoma is often located within the joint.Bony sclerosis occurs at the area of extra-articular anteromedial cortical surface of the femur neck.CT examination remains an optimal method to identify the nidus.

OBJECTIVE:Study on the efficiency of azithromycin sustained-release vaginal suppository in inhibiting ureaplasma urealyticum(Uu)in vitro.METHODS:The method of microdilution was used to determine the minimal inhibitory concentration(MIC)for Uu that azithromycin sustained-release vaginal suppository campared with azithromycin dried suspension. RESULTS:The MIC for Uu that both azithromycin sustained-release vaginal suppository and azithromycin dried suspension is lower than 0.125?g?mL~(-1).CONCLUSION:Azithromycin sustained release vaginal suppository has significant inhibitive effects on Uu under the experiment condition.

Adrenal Gland Neoplasms ; metabolism ; pathology ; Aged ; Antigens, CD20 ; analysis ; CD79 Antigens ; analysis ; Humans ; Immunohistochemistry ; Lymphoma, Large B-Cell, Diffuse ; metabolism ; pathology ; Male

Objective To investigate the effects of constant magnetic field (CMF) on proliferation, apopto-sis and nitric oxide (NO) secretion of rat bone marrow-derived endothelial progenitor cells (EPCs) intervened by C-reactive protein (CRP). Methods EPCs were isolated from rat bone marrow by density gradient centrifugation and cultured on fibronectin-coated dishes. The cells were divided into five groups, i. e., control group, CRP (12 μg/ml) group, CRP plus CMF (0.1, 0. 5, 1.0 mT) groups. Samples were collected 24 hours after incubation. Cell proliferation was measured by MTT chromatometry. Apoptosis rate was detected by flow-cytometry. NO content of culture medium was measured by nitrate reductase method. Results As compared with control group, cell prolifer-ation in CRP group reduced significantly (0. 265±0. 008 vs 0. 316±0. 011, P < 0.05), NO secretion also de-creased significantly [(22.7±4.5) μmol/L vs (37.6±3.8) μmol/L, P < 0.05], cell apoptosis rate elevated sig-nificantly [(10.8±0. 8) % vs (4.2±0.5)% ,P < 0.05]. Cell proliferation in CRP plus 0. 5 mT or 1.0 mT CMF group (0. 295±0. 009,0. 302±0. 010) were much more than those in CRP group (P<0.05), NO secretion contents [(28.3±4.9) μmol/L, (29.2±5.6) μmol/L]were also much more than those in CRP group (P < 0.05) , apopto-sis rate [(7.4±0.5)% ,(6.9±0.6)%]was significantly lower than that in CRP group (P <0.05). Conclusion CMF at intensity of 0.5 mT and 1.0 mT can antagonize the effects of CR, promote proliferation of EPCs and secretion of NO and inhibit apoptosis rate of EPCs.