OBJECTIVE:To discuss the approaches to carry out health education among patients with diabetic mellitus.METHODS:The significance of carrying out health education among patients with diabetic mellitus and the challenges existed were analyzed.RESULTS & CONCLUSION:Clinical pharmacists can carry out education among outpatients and public education to provide patients with basic knowledge,and the knowledge about drug treatment,blood glucose monitoring to effectively enhance the tertiary prevention of diabetes and patients' ability of self-nursing and survival quality.

Objective:To analyze the risk factors in the incidence of diabetic ketosis ( DK) in diabetic patients complicated with chronic renal insufficiency ( CRF) . Methods:Totally 82 diabetic patients with CRF were selected from our hospital. The data was col-lected using the questionnaire survey, and the influencing factors in the incidence of DK were analyzed. Results:According to the sin-gle factor analysis, 15 influencing factors had statistical significance in the DK incidence. The Logistic regression analysis indicated that the incidence of DK in diabetic patients with CRF was negatively correlated with age, complication and medication compliance, while was positively correlated with HbA1c. Conclusion:The incidence of DK is decreased with the increase of age, complication and medication compliance, while the higher HbA1c, the more DK occurs. Clinical pharmacists should pay attention to the regular patient education, strengthening the follow-up after discharge and individualized drug delivery in order to ensure the effective control of blood sugar and reduce the occurrence of DK.

Objective To evaluate the value of endoscopic treatment for severe acute biliary pancreatitis (SABP). Methods A total of 36 patients with SABP, who received emergency operation were enrolled into this study. Among the patients, 16 received endoscopic naso-biliary drainage (ENBD) because of acute cholecystitis or cholecystolithiasis; 11 underwent endoscopic sphincterotomy (EST) and ENBD due to stenotic papillitis or choledocholithiasis; 4 were treated with EST using needle knife and ENBD due to difficulties in inserting bow knife and cannula catheter into the common bile duct; and 2 experienced the guide wire entering into the wirsung’s duct for over 3 times, when the cannula catheter was inserted into the common bile duct. Thus, the sphincter of Oddi was incised by bow knife to expose the opening of the cystic duct, and then ENBD was performed. Open surgery was performed in 3 cases because of failure of ENBD. In all the patients, systemic medical treatment was carried out after the operations.Results ENBD was completed in 33 cases, among which 29 (81%) patients were cured and 4 (11%) patients died. The operation failed in 3 cases. After the operation, 3 patients developed peripancreatic infection. No hemorrhage of the duodenum papilla, duodenal perforation, or cholangitis occurred in this series. The mean hospital stay was 22 d (15-75 d). 26 of the cured patients were followed up for 12-36 months (mean, 18 months), no recurrence of the symptoms of pancreatitis was found. Conclusions Endoscopic treatment combined with systemic medical therapy may reduce the course of disease and increase the cure rate for patients with SABP.

Considering the World Health Organization's classification of Helicobacter pylori as a definite (class I ) carci- nogen, the relationship between oral microbial community and tumors is gaining increased interest. This review focused on three relationships between oral microbiota and tumors, i.e., between oral Helicobacter pylori infection and gastric tumors, between oral microbiota and oral squamous cell carcinoma, and between human immunodeficiency virus and tumors. The aims were to realize the early diagnosis of tumors with oral microbiota and support studies on treatment development.
Helicobacter Infections ; Helicobacter pylori ; Humans ; Mouth ; microbiology ; Mouth Neoplasms

Objective:To analyze the influential factors on the medication compliance of the patients with diabetes, and investigate the measures to improve it.Method:A total of 200 patients were investigated with questionnaires and interview in the study.Result:There was no significant difference in the compliance among the patients with different sexes, ages and payment modes,while some significant results emerged with respect to their culture,incomes,courses and their initiatives,conceptions and knowledge in the drug use.Conclusion:In order to improve the compliance of patients, clinical pharmacists could do jobs in many ways by means of combinative measures.

Humans ; Hyperparathyroidism, Secondary ; Parathyroidectomy ; Renal Insufficiency

Objective To study the inhibition effects of 10-hydroxycamptothecinc and low molecular weight heparins on human hepatocellular carcinoma(HCC)in nude mice.Methods Metastatic model of HCC was established in nude mice.The model mice were randomly divided into 4 groups:the control group,10- hydroxycamptothecinc group,low molecular weight heparins group,and combined treatment group(10-hy- droxycamptothecinc and low molecular weight heparins).Tumor sizes,tumor inhibition rates,tumor metas- tases,intratumoral microvessel density(MVD),CD_(31)and AFP were evaluated.Results In comparison with the control group and the 10-hydroxycamptothecinc group,the tumor sizes of the low molecular weight heparins and the combined treatment group were significantly smaller;the tumor inhibitor rates were 0 versus 76.6%, 79.8%,94.1%;MVD were 21.1?6.5 versus 17.2?3.1,7.1?2.3 and 4.8?1.8;CD_(31)were 31.7?6.1 versus 26.2?5.2,20.9?4.7 and 19.5?2.4;the incidence of liver metastasis was 80% versus 70%,20% and 10%;lung metastasis was 70% versus 60%,20% and 10%;the peritoneal metastasis was 90% versus 60%,30% and 30%.AFP were(121.9?31.4)ng/ml versus(56.2?37.9)ng/ml,(75.6?28.7)ng/ml and(20.7?12.9)ng/ml. Inhibiting effects of growth and metastasis of HCC in 10-hydroxycamptothecinc group,low molecular weight heparins group and combined treatment group were significantly different from those of the control group(F= 9.074,P

Objective To investigate the effect of nobiletin,a citrus polymethoxy flavonoid,on hepatocarcinoma Heps in mice and to explore its immunological mechanism.Methods Mice tumor models were made by transplantation of Heps hepatocarcinoma cell strain.The tumor mass was weighed to calculate the tumor-inhibitory rates.The whole cellular immunity was observed by delayed type hypersensitivity(DTH).MTT assay was used to detect the proliferation of T and B lymphocyte,and the activities of cytotoxic T lymphocytes(CTL) and natural killing cells(NKC) were measured by lactate dehydrogenase(LDH) releasing method.Results Nobiletin could markedly inhibit the growth of hepatocarcinoma Heps(solid tumor).The decreased DTH in hepatocaricinoma mice was enhanced significantly,and T and B lymphocyte proliferation were increased by nobiletin.Meanwhile,the killing activities of CTL and NKC were promoted obviously.Conclusion Improvement of the immune function may be a vital route of nobiletin in inhibiting the proliferation of hepatocarcinoma Heps in mice.

Objective To evaluate values of laparoscope,duodenoscope,choledochoscope and seven procedures for extrahepatic biliary calculi.Methods From Junuary 2002 to June 2006,clinical data of 246 cases of extrahepatic biliary calculi treated by three kinds of endoscope and seven procedures were reviewed retrospectively.Laparoscope(Ⅰa) was used in 8 cases,duodenoscope(Ⅰb) in 27 cases,choledochoscope(Ⅰc) in 17 cases,laparoscope combined with choledochoscope(Ⅱa) in 83 cases(including transferred 9 cases),laparoscope combined with duodenoscope(Ⅱb) in 102 cases,choledochoscope combined with duodenoscope(Ⅱc) in 3 cases(all transferred),combined three kinds of endoscope(Ⅲ) in 21 cases(containing transferred 3 cases).Results The success rate of all procedures was 82%-100% without severe complications.Residual stones in biliary tracts were removed once again successfully in 10 cases.The mean of follow-up period was 25.6 months(range,3 months to 4 years).No biliary tract stenosis was observed in 202 cases and stone recurred in 15 cases.Conclusions Three kinds of endoscope and seven procedures supplement minimally invasive treatment.As seven procedures have different indications respectively,the principle "one endoscope preference,main application of two endoscopes,and reasonable application of three endoscopes" should be followed.

Objective To compare the analgesia and side-effects of different concentrations of sufentanil combined with 0.125% ropivacaine for postoperative epidural analgesia after general thoracic surgery.Methods Thirty-six ASA Ⅰ-Ⅲ patients (25 males, 11 females) ages 21-64 yrs weighing 42-79 kg undergoing elective general thoracic surgery under general anesthesia were randomly assigned to receive patient-controlled epidural analgesia (PCEA) with 0.125% ropivacaine combined with sufentanil 0.4 (group A, n = 12) , 0.5 (group B, n = 12) or 0.6 ?g?ml-1 (group C, n = 12) . Epidural catheter was placed at T7,8 or T8,9 interspace. The PCEA pump was set up with back ground infusion of 2 ml?h-1 , a3ml bolus dose and a 30-min lock-out period. VAS scores was used to assess analgesia at rest and during movement. The total bolus doses, PCEA button pressing times (effective/actual), vital signs including MAP, HR, respiratory rate, SpO2 and side effects (nausea, vomiting, pruritus and dyspnea) were recorded. Results During the 48 hours after operation the VAS scores in group C were significantly lower than those in group A and B ( P