Objective:To investigate the proper method for treating traumatic chyloperitoneum. Methods: A retrospective analysis was performed on clinical data of 4 cases of traumatic chyloperi- toneum admitted to our hospital in recent 26 years. Results: All 4 cases were cured after conserva- tive treatment. Conclusion: Perdominantly integrated therapy including absolute diet,total parrenter- al nutrition(TPN) and abdominal cavity drainage can be the effective method for the treatment of trau- matic chyloperitoneum.

Objective To investigate the biological effects of nonthermal plasma (NTP) combined with X-ray irradiation on human hepatocellular carcinoma in nude mice.Methods By subcutaneous inoculation, tumor models of human hepatocellular carcinoma HepG2 in nude mice were established, and these mice were divided into control group, NTP treatment group, X-ray irradiation group, combined treatment group.The changes of tumor microenvironment were observed using hematoxylin-eosin (HE) staining.The terminal deoxynucleotidyl transferase-mediated nick end labeling (TUNEL) was used to determine the level of neuronal apoptosis in tumor tissues.The expression of metal matrix proteinase-2 (MMP-2) was detected by immunohistochemical assay.Transmission electron microscope was used to observe cell structure changes.Results The final tumor volumes of control group, NTP treatment group, X-ray irradiation group, combined treatment group were (543.96±108.45), (436.54±65.49), (351.66±56.68), (281.97±35.60)mm3, with a statistically significant difference (F=9.63, P=0.01), and the difference between X-ray radiation group and the combination treatment group was significant (P=0.05).HE staining showed that there was a larger area of necrosis in the combined treatment group compared with the other groups.TUNEL showed that the apoptotic indexes were (0.95±0.13)%, (5.82±0.26)%, (7.53±0.43)%, (11.07±0.35)% respectively, with a statistically significant difference (F=547.76, P=0.00), and the difference between X-ray radiation group and the combination treatment group was statistically significant (P=0.00).The immune scores of each group were 12, 9, 9, 2.Electron microscopic observation showed that there were more apoptotic bodies in the combined treatment group than those in the other groups, accompanied by mitochondrial edema.Conclusion NTP and X-ray irradiation therapy in the treatment of human hepatocellular carcinoma in nude mice model has a synergistic effect.Probably, it can be a new type of treatment in curing cancers.

Objective To investigate the direct economic loss of nosocomial infection at a tertiary hospital, so as to provide data support for the improvement of hospital infection control. Methods Inpatients discharged in 2013-2015 period were divided into two groups at a 1:1 pairing ratio, having those suffering from nosocomial infection in only one occasion as the infection group, and those without as the non-infection group. The two groups were compared of their differences in days of stay and hospitalization expenses. Results The days of stay of the infection group were significantly longer than the non-infection group, averaging 6 days longer in terms of the median. Compared with the non-infection group, the total hospitalization cost and the differences with sub-categories other than the treatment cost were of significance. The costs over the non-infection group were mostly contributed by drugs, accounting for 50. 39%, while 23. 50% of which were spent on antibiotics. The additional antibiotics costs were mainly incurred by respiratory tract infections during hospitalization, as the costs of antimicrobial agents for the infection group were 27. 34 times that of the non-infection group. The second contributor was surgical site infection, with the cost of antibiotics 7. 63 times that of the non-infection group. Conclusions Hospital infections prolong the days of stay, increase direct economic loss, especially increase the cost of antibiotics. Prevention and control of respiratory system and surgical site infection can effectively reduce the direct economic loss of hospital infection.

General practice education at higher medical university is the foundation of the general practice educational system. It has close relationship with the cultivation quality of the general practitioners. By taking British and Australian medical colleges as examples, the paper introduced the current situation of British and Australian general practice education for undergraduate medical stu-dents and elaborated their theory learning content, their practice learning content ,their education re-form and research progress and their education target and effect. General practice education in Britain and Australia sheds light on how to set theory course, arrange practice part and improve educational research, which general practice education in China can draw lessons from.

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Objective To explore the clinical features,risk factors and the sensitivity to antibiotics of lower respiratory tract acinetobacterial infection.Methods The clinical data,results of sputum bacterial culture and drug sensitivity of the 72 cases with lower respiratory tract acinetobacterial infection were netrospectively reviewed.Results 53 cases(73.6%)were elder than 60 years old,69 cases(95.8%)had basic diseases,and 59 cases(81.9%)were nosocomial infection.Risk factors included basic diseases,lower immune function,all kinds of invasive operations,aerosol inhalation,unreasonable usage of antibiotics.Drug sensitivity test showed that the drugs which sensitive to acinetobacter was upper than 50% included Imipenen,Levofloxacin,Cefooerazone/sulbactum and Amikacin.Conclusion The patients who sufferred from lower respiratory tract acinetobacterial infection usually are elder than 60 years old,and have basic diseases.Most of this kind of infection is nosocomial infection.Because of severe clinical symptom and high drug resistant rate,the prognosis is poor.Reasonable selection of sensitive antibiotics is important.

ObjectiveTo compare the efficacy of laparoscopic appendectomy(LA) and open appendectomy (OA) in treating acute appendicitis.MethodsThe clinical data of eighty patients admitted with acute appendicitis given LA or OA were setrospectively studied and the recovery condition after LA or OA of the two groups were compared.ResultsTime of gastrointestinal functional recovery and hospital day of the LA group were obviously shorter than the OA group[(15.1±7.2)d vs (28.0 ± 11.3)d,(4.2 ±1.9)d vs (5.5 ±3.2)d,all P ＜0.05].The rate of postoperative complications after LA was fewer too.ConclusionLA had advantages of faster function recovery,shorter hospital day and fewer complications,which had higher clinical application value.

[Purpose] Study measures and solutions to students ’employment problem. [Methods] Adopt basic research methods such as literature review, in-dividual interview, data analysis, etc. [Result] Students ’employment situation is grim in Traditional Chinese Medicine col eges and universities, the em-ployment work needs to be enhanced in many aspects. [conclusion] Traditional Chinese Medicine col eges and universities should improve the quality of employment work through strengthening students’competition ability and optimizing the structure of talent training.

Statins may not only lower cholesterol concentration,reduce the incidence of heart diseases and relieve kidney damage,but also stimulate bone formation obviously,as suggested by a number of observation studies and animal researches.However,the exact mechanism of promoting bone formation has not been very clearly yet.Moreover,their adverse effects and their interaction with other drugs still need further clinical trials.In this review,on the basis of clinical data about the effects of hydroxymethylglutaryl-CoA(HMG-CoA)reductase inhibitors,we summarize current hypotheses on their mechanism and safety,in order to provide reference for the domestic bone reconstruction research.

The success of ATRA and ATO in APL treatment furuishes the first model of molecular target-based induction of differentiation and apoptosis.Two drugs all target PML-RARα oncoprotein through different moieties and induce APL cells differentiation and apoptosis.In acute myeloid leukemia M2b,we reveal that gain-of-function of C-kit coexists with persistent AML1-ETO,suggesting that abnormal C-kit may serve as a therapeutic target in AML L-M2b Oridonin becomes a potential candidate target drug which specifically degrades AML1-ETO protein. Experiment in vitro proves the combinatorial effectiveness of imatinib and cytarabin in the treatment of chronic myelogenous leukemia(CML).Imatinib is an inhibitor of abnormal protein tyrosine kinases activity. While arsenic agent triggers the degradation of bcr-abl, and combination of the two drugs in treating CML leads to a better outcome.