Of all types of intracranial hemorrhage (ICH) in the neonates, germinal matrix intraventricular hemorrhage(GM-IVH) in the premature infant is the most common type, mainly attributed to the existence of immature germinal matrix, lt's usually lack of visible and specific symptoms and signs in the nervous system, so its early and final diagnosis depends on the imaging examine. GM-IVH can cause periventricular hemorrhagic infarction, post-hemorrhagic hydrocephalus, periventricular leukomalacia and the associated cerebellar hemorrhagic injury, which are critical determinants of neonatal morbidity, mortality, and neurodevelopmental outcome in the survivors. The overall aim of this article is to review the current knowledge of the cause,mechanisms, imaging diagnosis, complication, management and outcome of GM-IVH in the preterm infant.

Many studies have demonstrated that blockade of angiogenesis by antiangiogenic drugs in di-fferent ways can control the growth of tumor.Antiangiogenic agents can target different sites:vascular growth pro-moting f_ators,endothelial cells,basement membrane degradation,epidermal growth factor receptor,ete.Antian-giogenic agents have promising prospect.

Objective To analyze the effect of CO2 laser under suspension laryngoscope on patients with vocal cord polyp. Method 118 patients with vocal cord polyp from November 2013 to August 2015 in our hospital were chose as research subjects, all patients were divided into observation group (n=54) and control group (n=64) accord﹣ing to different treatment. Control group: patients received conventional laryngoscope resection; observation group:patients received CO2 laser under suspension laryngoscope. Then compare the two group patients' voice indexes, a﹣cute phase proteins, rehabilitation and recovery speed after treatment. Results Observation group patients' F0, HNR values were higher than control group patients, PPQ, APQ, NNE values were lower than that in control group (P<0.05);early observation group patients' postoperative serum CRP, α1-AG, CER,β2-MG values were lower than con﹣trol group patients, ALB value was higher than control group patients (P< 0.05); observation group patients' cure rate was higher than control group patients, valid and invalid rates were lower than control group patients, the first sound time, sound full recovery time, discharge time were shorter than control group patients (P< 0.05). Conclusion Vocal cord polyp patients receive laser under suspension laryngoscope treatment, can effectively promote recovery rate, have advantages of minimally invasive and rapid recovery after surgery.

Radiotherapy is important in cancer treatment, but improving the therapeutic effect of irradiation and decreasing its toxicity to normal human tissues is still a global problem. Epidermal growth factor receptor (EGFR) is a member of ErbB family and is an important transmembrane receptor with signal-transduction tyrosine kinase activity. EGFR can direct cellular migration, adhesion, proliferation, differentiation, and apoptosis, and plays a fundamental role in the development and growth of many types of human tumor cells. A series of preclinical studies showed that EGFR inhibitors can enhance the antitumor activity of ionizing radiation. EGFR inhibi-tors regulate radio-sensitization through multiple mechanisms, including cell cycle alterations, DNA repair modulation, and anti-angio-genesis. Reasonable application of EGFR inhibitors will effectively increase the radio-therapeutic effect, extend the local control of tu-mor, and improve a patient's quality of life.

Gastrointestinal bleeding is a severe,complicated and commonly seen disease in Department of Digestive Diseases,the frequent etiology is peptic ulcer,acute gastric mucosal lesion,esophageal gastric varices and digestive tract tumors. In recent years,clinicians gradually noticed a kind of disease characterized by acute,recrudescent and life-threatening bleeding,that is the non-variceal vascular originated gastrointestinal hemorrhage. The guidelines and scholars have not paid enough attention to this problem. However,non-variceal vascular originated gastrointestinal hemorrhage is not uncommon,and is difficult and tricky in its management for clinicians. Therefore,clinicians should pay sufficient attention to the characteristics and therapeutic principles of non-variceal vascular originated gastrointestinal hemorrhage.

P300/CBP is one of the most important high molecular weight protein histone acetyltransferase ( HAT) Although it is encoded by multiple different genes , P300/CBP is highly homologous , Because they have the similar amino acid sequence and functions ,and belong to the same class of proteins ,normolly they are all called P300/CBP.P300/CBP is involved in the activation of many kinds of transcription factors ,the protein itself alsohas acetyltransferase activity ,and is capable of acetylation of 4 core histones and transcription factor .More and more studies have confirmed the relationship of P 300/CBP variation withmultiple human diseases , including in-flammation,diabetes,heart disease and especially cancer .In tumor P300/CBP is associated with some pathways , and these pathways play a different roles in the tumor .Although P300/CBP is usually regarded as a tumor sup-pressor factor ,is plays different roles in different tumors ,This review mainly introduces the relationship of P 300/CBP with some solid tumor disease genes ,related transcription factors and their signaling pathways .

Objective:The current evidence suggests that tumor necrosis factor-inhibitor (TNFi) treatment can be used to achieve clinical remission or low disease activity in patients with ankylosing spondylitis (AS). After achieving remission / low disease activity, however, the follow-up treatment options are unclear. The purpose of this review is to conduct an extensive and systematic literature review of the studies conducted from September 2014 to July 2020 to assess the feasibility and effectiveness of tapering of biological agents.Methods:After searching for the related papers and abstracts and applying inclusion/exclusion criteria, a structured extraction process was used to include the studies into this study.Results:A total of 13/93 studies were included into the analysis of the tapering of biological agents in AS patients, in which 7/13 adopted the dose reduction regimen, 3/13 adopted the extended interval between doses regimen, and 5/13 did not provide or formulate the detailed reduction regimen. We summarized the feasibility of TNFi tapering schemes in the published studies and summarized the tapering rules. Only one study showed that reduced TNFi levels worsened the quality of life and resulted in a relapse within 12 months.Conclusion:More research is needed to understand the long-term effects of these strategies on efficacy, safety, and cost in the treatment of AS.

The rapid development of artificial intelligence technology has achieved a breakthrough in many disciplines. Artificial intelligence has a far-reaching significance in promoting the further development of laboratory medicine. At present, artificial intelligence technology has gradually penetrated into all processes of laboratory work, such as laboratory data processing, laboratory data mining and laboratory quality control. It not only improves efficiency, but also provides important information for clinical diagnosis and treatment supporting information. The functions of laboratory physicians are likely to undergo corresponding transition and adjustment in the future. Therefore, it is a general trend to promote the development and leap of the next generation of laboratory medicine by artificial intelligence, and the future of laboratory medicine will usher in the "artificial intelligence era".

Objective To evaluate the effect of splenectomy on hematological and immune system for children with major thalas‐semia .Methods This retrospective study was performed on 68 children with major thalassemia .The indexes of blood and immune system included white blood cell ,red blood cell ,hemoglobin ,platelet ,immunoglobulin IgG ,IgM and IgA and serum complement C3 , C4 ,which were recorded at pre‐splenectomy ,3 months and 3 -12 months post‐splenectomy .Results The mean age of children in this study was 8 .6 ± 3 .1 years .There were 28 children with α‐thalassemia ,35 with β‐thalassemia and 5 with αβ‐thalassemia .The white blood cell ,red blood cell and platelet count increased significantly both at 3 and 3-12 months post‐splenectomy as compared with pre‐splenectomy .The red blood cell and hemoglobin in children with β‐thalassemia or αβ‐thalassemia were significantly lower than children withα‐thalassemia both at pre and post‐splenectomy .However ,the platelet count were similar .The immunoglobulin IgA and IgM were significantly lower at post‐splenectomy than pre‐splenectomy .However ,the IgG ,C3 and C4 did not decrease sig‐nificantly .Conclusion Splenectomy could increase the hemoglobin level and improve the anemia in children with major thalassemia . However ,it might be harmful to the immune system .

Object To develop a method for the separation and purification of polyprenyl acetates from the leaves of Ginkgo biloba L Methods Lipids, including polyprenyl acetates were extracted by petroleum ether, and adsorbed by silica gel to remove most of the polar impurities After removing wax from the partially purified extract, it was further purified with silica gel chromatography Results Finally, a mixture of homologues polyprenyl acetate was obtained The purity of which as determined by HPLC external standard method was 84% Conclusion This procedure is simple and relatively effective