Adult ; Automobile Driving ; Female ; Hip Fractures ; etiology ; Humans ; Male ; Middle Aged ; Occupational Injuries ; complications ; Retrospective Studies ; Young Adult

Objective To analyze the clinical behavior and correlative mechanism of the patients with the syndrome of neck injury associate with craniocerebral injury,to investigate its incidence for contributing to the diagnosis and therapy of the patients with the craniocerebral injury and improving the postoperative result. Methods Two hundred and eighty-three patients with craniocerebral injury treated from June 2000 to July 2003 were studied retrospectively. Results In 283 patients, 42( 14.8%) patients presented the syndrome of neck injury clearly in symptom or sign, of whom 39 ( 13.7% ) patients were diagnosed neck injury finally, 3 (1.1%) patients were clinically conclude neck injury. The syndrome mainly presents with noncerebral and nonaural vertigo incorresponding with the recovery of brain injury. Noncerebral, nonaural and nondigestive vomit. Intractable nuchal rigidity incorresponding with the recovery of brain injury. Motion and position limited, stubborn neck malaise, transient spinal cord injury. The symptoms were easy to be improved by neck motion control, neck traction,block therapy, massage and physiotherapy lamp. Conclusion The syndrome of brain-neck injury is a common injury. To learn the syndrome and take the regular therapy can improve the therapeutic efficacy of the craniocerebral injury.

Objective:To analyze CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis versus chronic pancreatitis in order to improve its CT differential diagnostic accuracy.Methods:CT findings in 14 cases of pancreatic carcinoma coexisting with chronic pancreatitis and 15 cases of chronic pancreatitis were retrospectively analyzed.Both plain and enhanced CT scans were performed in all cases.Thin-layer scan was practiced when required.Observation was focused on the size,shape,density of pancreas,its relationship with Peripancreatic tissues,the images of enhancement,and the location,size,density of pancreatic carcinoma.Moreover,observation was focused on the dilation of common bile duct,main pancreatic duct and hepatic bile duct Then,CT characteristics of pancreatic carcinoma coexisting with chronic pancreatitis and chronic pancreatitis were analyzed and compared.Results:In the pancreatic carcinoma coexisting with chronic pancreatitis group,all cases have mass,and noenhancement in the arterial phrase.Peripancreatic blood vessels were invaded or surrounded(5 cases and 4 cases respectively).Peripancreatic adipose were not seen enough(5 cases).Lymph node enlargement(4 cases),Liver metastasis(5 cases).Dilation of common bile duc(t8 cases,9.67 mm?2.64 mm),6 of which showed broke off abruptly.Pancreas atrophy(6 cases),Calcification(4 cases),Dilation of main pancreatic duc(t7 cases),Pseudocys(t2 cases).In chronic pancreatitis group,pancreatic mass(2 cases),one of which showed no enhancement in the arterial phrase;Peripancreatic blood vessels was surrounded by Peripancreatic mass and the boundary between blood vessels and adipose was not clear(1 case);None of the cases was seen Peripancreatic blood vessels invasion;no liver metastasis or Lymph node metastasis.Dilation of common bile duc(t3 cases,7.53 mm?1.45 mm),one of which showed broke off abruptly.Pancreas atrophy(7 cases),Calcification(5 cases),Dilation of main pancreatic duct(7 cases,4.73 mm?3.04 mm),Pseudocyst(4 cases).Conclusion:Style of mass dynamic enhancement of pancreatic carcinoma coexisting with chronic pancreatitis,Peripancreatic blood vessels invasion,liver metastasis,and lymph node metastasis are important basis of CT differentiation of pancreatic carcinoma coexisting with chronic pancreatitis from chronic pancreatitis.

Vav3 oncogene is a member of the Vav family. Vav3 protein contains multiple functional motifs and is involved in cancer development and progression through its role in various cellular signaling processes, including cytoskeleton organization, calcium influx, genetic transcription, cell transformation, proliferation and apoptosis. In addition, Vav3 interacts with estrogen receptor and enhances ERα-mediated signaling axis, therefore plays an important role in breast cancer.

Coronary Artery Bypass ; methods ; utilization ; Coronary Artery Disease ; pathology ; surgery ; Graft Survival

OBJECTIVE: To estimate and optimize the dosing regimens of antibiotics in general surgery with the utilization of Monte Carlo simulation (MCS) based on PK/PD. METHODS: The mean treatment duration(MTD) of different dosing regimens were gathered from clinical cases. MCS model was used to simulate the regimens against Escherichia coli, Klebsiella pneumonius, Acinetobacter baumannii and Pseudomonas aeruginosa, respectively. RESULTS: The CFRs of 500 mg TID, 500 mg QID, 1.0 g BID and 1.0 g TID imipenem against Escherichia coli and Klebsiella pneumonius were greater than that of 500 mg BID (100%; 99%). Correspondingly, MTD of those regimens achieved CFR 100% were shorter than that of 500 mg BID. The CFRs of imipenem against Acinetobacter baumannii and Pseudomonas aeruginosa were all less than 90%, the CFRs of 200 mg BID, 400 mg QD levofloxacin and 200 mg QD, 200 mg BID, 400 mg QD amikacin were all below 90%. CONCLUSION: The 5 dosing regimens of imipenem were all effective against Escherichia coli and Klebsiella pneumonius. In consideration of pharmaceutical economics, 500 mg TID was the most rational choice. It suggested drug resistance and promoted combined medication that the CFRs of imipenem against Acinetobacter baumannii and Pseudomonas aeruginosa failed to achieve 90%. Drug resistance was also demonstrated by low CFR values of levofloxacin and amikacin treatments. Nevertheless, results of MCS showed inversely proportional between MTD and CFRs, and displayed obvious dose-dependent characteristics of levofloxacin and amikacin. On the purpose of achieving effective concentration, sufficient dose once a day of levofloxacin and amikacin medication were recommend.

Objective:To test the microtensile bonding strength between root canal wall and Bis-Core, and that between root canal wall and Chemil Superior glass-ionomer.Methods:10 human maxillary incisors extracted within one week were kept for another one week after root canal treatment and removeal of the crowns,each root was splited into two parts along with the long axis by Isomet saw, the bonding interface on one third of upside of root dentin smear layer was made with Diamond bur at a high-speed. Then Bis-Core and Chemil Superior glass-ionomer were put on root canal inner surface of each half part of the root respectively, samples with the size of 1.00 mm?1.00 mm were prepared by Isomet saw. Two samples in which bonding interface was perpendiculur to load were selected and fixed in Microtensile testing machine for bonding strength test. Results:Microtensile bonding strength(MPa) between Bis-Core and root canal inner wall and that between root canal inner wall and Chemil Superior glass-ionomer was 20.65?1.72 and 12.89?1.63 respectively(P

Objective:To observe the microstructure of interface between material and dentin after root canal rehabilitation. Methods:Three human maxillary incisors extracted within one week were used. After crowns being removed and received root canal treatment, they were used for the study. The root was split into two parts along the long axis, then the bonding interface was made with high speed diamond bur. Bis-Core and Chemil Superior glass-ionomer were stacked on root canal inner wall respectively and the teeth were split along with the long axis with Isomet saw, in order to expose bonding interface. The microstructure of bonding interface of the samples were analyzed by optical microscope and atomic force microscope(AFM). Results: AFM observation of the adhesive interface specimens showed that Chemil Superior glass-ionomer and teeth knitted together completely and no filling invaded into dentin tube. While the bonding interface between Bis-Core and dentin, dentin primer infiltrated into dentin tube and matrix around through the smear layer and colophony protruded. Conclusion:The observations reveal the extent of resin penetration into the dentinal tubules provides a very strong bonding. This is a fundamental cause of resin better bond to tooth.

Medicine is a comprehensive discipline.Under the new situation,medical students are required to have integral knowledge and whole view.This article aims at evaluating the necessity of diagnosis and discusses the defects,causes and strategy in this respect.

Due to the complicated and changeable clinical symptoms,and inexact pathogenesis,leukemia was facing huge challenges in diagnosis and therapy.Aptamer could be selected through CELL-SELEX.The aptamer not only display high affinity and specificity to target cell,but also it could discriminate the specific stage of cell,such as different classification,normal and tumor cells.So CELL-SELEX has great potention in the researches of leukemia.This paper systematically summarized the advantages of CELL-SELEX,the application in specific leukemia diagnosis,targeted therapy and the discovery of cancer biomarkers.(Chin J Lab Med,2013,36:377-379)