Stromal cell-derived factor-1(SDF-1)is an early cell growth factor which belongs to a subfamily of chemokines.The CXCR4 is SDF-1 receptor.The SDF-1 interacting with CXCR4 plays important roles in physiological and pathological processes such as hematopiesis, stem cell homing,angiogenesis and leukemic cells infiltrating.To study the expression of CXCR4 in leukemia and the relationship between CXCR4 and leukemic cells infiltration can add indicators for leukemic MIC diagnosis of immunology indexes and have great significance to take molecule targeted therapy for preventing leukemia from infiltration or relapse as well.

Medicine, Chinese Traditional ; methods

Adult ; Anaphylaxis ; etiology ; Female ; Humans ; Male ; Semen ; immunology

China ; Health Promotion ; methods ; Health Status ; Humans ; Nutritional Status ; Social Class ; Socioeconomic Factors

China ; Food Safety ; Risk Assessment

China ; Humans ; Medicine ; Nobel Prize

Drug Therapy, Combination ; Drugs, Chinese Herbal ; therapeutic use ; Humans ; Medicine, Chinese Traditional ; Phytotherapy

Child ; Child, Preschool ; China ; epidemiology ; Food Contamination ; Humans ; Infant ; Infant Formula ; chemistry ; Infant, Newborn ; Triazines ; poisoning ; Urinary Calculi ; chemically induced ; epidemiology

Toll-like receptors(TLRs), as the family members of type Ⅰ transmembrane receptors, play a pivotal role in both innate and adaptive immune responses. Recently, TLRs are believed to be the cntical receptors in innate immunity . Innate immunity activated by the recognition of exogenous or endogenous by TLRs induces multiple cytokines that is the key factor to affect differentiation of naive T cells. Abnormal activation of TLIRs may cause the functional imbalance of Th1, Th2, Th17 and Treg, resulting in the occurence of autoimmune disease.

Based on multiple painless needle insertion skills in clinic combined with own experience, the authors propose the opinion that different painless needle insertion methods need to be used according to the positions where acupoints are. The appropriate needle insertion mean must be selected in accord with the anatomical characteristic of acupoint position, namely, tapping insertion is applied in scalp part, skin-pinching up needle insertion is used in forehead and superficial nerve trunk, fingernail-pressure needle insertion in ocular region and positions where large blood vessels distribute, flying acupuncture insertion in face and finger tip, vibrating needle in occipitonuchal region, quivering insertion in abdomen, quick pricking by single hand in the four limbs and back, and chop acupuncture in palm and pelma. The insertion methods are systematically discussed in terms of preparation, acupoint position, manipulation and attention, etc, so that to provide the reference for painless needle insertion.
Acupuncture Points ; Acupuncture Therapy ; instrumentation ; methods ; Humans ; Meridians ; Needles