Objective To summarize the experience in perioperatively nursing 8 patients with pelvic cavity and genital tract aggressive angiomyxoma (AAM). Method The perioperative nursing care was given to 8 AAM patients who were hospitalized in the department of obstetrics and gynecology from January 2010 to June 2015. Results The abdominal and perineal wounds were healed well without complications. All patients were recovered and discharged. One case had a relapse 2 years and another did 3 years after operation. Conclusion Such nursing measures as preoperative psychological nursing, close observation of the disease conditions, nursing cooperation during rescue for postoperative bleeding, treatment of postoperative complications and enhancing health education concerning the importance of long-term follow-up can be helpful for their recovery.

OBJECTIVE:To establish the UPLC fingerprint for Qinghou liyan granule,and provide reference for its quality control by combining with principal component analysis (PCA). METHODS:UPLC was performed on the column of ACQUITY UPLC BEH C18 with mobile phase of acetonitrile(A)-0.1% aqueous phosphoric acid solution(B)(gradient elution)at a flow rate of 0.4 mL/min,the detection wavelength was 280 nm,column temperature was 30℃,and injection volume was 2μL. Using ellag-ic acid as a reference,12 batches of samples were analyzed,Similarity Evaluation Software for Chromatographic Fingerprint of Traditional Chinese Medicinewas used for the similarity analysis and identification of the common peaks,and the PCA was used for common peaks. RESULTS:There were 18 common peaks in the fingerprints of 12 batches of samples,and 6 principal peaks (gallic acid,ellagic acid,naringin,hesperidin,neohesperidin and baicalin) were identified;the similarity degree of 12 batches and reference fingerprints were no less than 0.984. According to PCA,the 18 peaks can be integrated into 3 principal components, with cumulative contribution rate of principal component of 78.277%;baicalin and 16 peaks were the discriminating factors of the fingerprint of Qinghou liyan granule. CONCLUSIONS:The method can provide reference for the quality control of Qinghou liyangranule.

Objective To explore the effect of benazepril combined with amoldipin on cardiac function and urine microalbuminuria in patients with moderate and severe primary hypertensive left ventricular hypertrophy.Methods 90 patients with mild to moderate essential hypertension and left ventficular hypertrophy were randomly divided into three groups(n=30 in each group),who were treated with benazepril,amoldinpin and benazepril com-bined with amoldipin,respectively.Blood pressure was monitored and left ventricular diameter(LVDd),interven-tricular septal thick(IVS),left ventricular posterior wall(LVPW),left ventricular masses index(LVMI)were measured by echocardiography before and after treatment in three groups.Microalbuminuria,serum nitrogen and creatinine were examined at the same time.Results Both SBP and DSP were significantly decreased in three groups after two weeks treatment.E/A ratio and EF were increased at the same time(P<0.01).After treatment,these changes were more significant in Benazepril with Amlodipine group(P<0.05).After 24 week treatment IVS,LVPW and LVMI were significantly dereased(P<0.01),while LVEF and E/A increased(P<0.01).After 4-week treatment,microalbuminuria was decreased in three groups,especially in combined treatment group(P<0.01).With the time of medication in combined treatment group,microalbuminuria was increasingly decreased which was significant in benazepril and amoldipin group after 24 weeks(P<0.01).Conclusion The Benzazepril with am-lodipine are more effective in lowering blood pressure,left ventricular hypertrophy and decrease microalbuminuria.

Objective To explore the effect of benazepril combined with amoldipin on cardiac function and urine microalbuminuria in patients with moderate and severe primary hypertensive left ventricular hypertrophy.Methods 90 patients with mild to moderate essential hypertension and left ventficular hypertrophy were randomly divided into three groups(n=30 in each group),who were treated with benazepril,amoldinpin and benazepril com-bined with amoldipin,respectively.Blood pressure was monitored and left ventricular diameter(LVDd),interven-tricular septal thick(IVS),left ventricular posterior wall(LVPW),left ventricular masses index(LVMI)were measured by echocardiography before and after treatment in three groups.Microalbuminuria,serum nitrogen and creatinine were examined at the same time.Results Both SBP and DSP were significantly decreased in three groups after two weeks treatment.E/A ratio and EF were increased at the same time(P<0.01).After treatment,these changes were more significant in Benazepril with Amlodipine group(P<0.05).After 24 week treatment IVS,LVPW and LVMI were significantly dereased(P<0.01),while LVEF and E/A increased(P<0.01).After 4-week treatment,microalbuminuria was decreased in three groups,especially in combined treatment group(P<0.01).With the time of medication in combined treatment group,microalbuminuria was increasingly decreased which was significant in benazepril and amoldipin group after 24 weeks(P<0.01).Conclusion The Benzazepril with am-lodipine are more effective in lowering blood pressure,left ventricular hypertrophy and decrease microalbuminuria.

Objective To explore the clinical characteristics and diagnosis of primary small intestinal tumor(PSIT). Methods Retrospective analysis of the clinical and pathological data of the 31 PSIT cases was made. Results Duodenum was the most common site 67.74% for PSIT. The confirmed diagnosis rate was 54.84%(17/31)(duodenum was 66.67%,14/21; ileum and jejunum was 30%, 3/10, respectively ). 3 cases were benign tumors and 28 were malignant tumors.The adenocarcinoma was the most frequently seen malignant PSIT followed by lymphoma and often in duodenal. The features of the small intestinal tumor could be abdominal pain,abdominal mass,hemorrhage,obstruction,jaundice and fever.The chief method for diagnose was barium meal X-ray examination, especially with the hypotonic contrast X-ray examination and endoscopy.Superior mesenteric arteriography sometimes helped in determing site of gastrointestinal haemorrhage. CT scan could be helpful in diagnosis. Conclusion Duodenal adenocarcinoma is most common PSIT,followed by malignant lymphoma.Endoscopy is the best way to find out the tumor located in duodenum and hypotonic contrast X-ray examination is effective in diagnosis and locating of small bowl tumors.Superior mesenteric arteriography is a good way to find out angioma and leiomyoma. CT scanning are also helpful.

OBJECTIVE To investigate the expression and clinical significance of epidermal growth factor receptor (EGFR), the mutations of gene EGFR, KRAS and BRAF in sinonasal intestinal-type adenocarcinomas. METHODS We investigated the EGFR protein expression by immunohistochemistry method with antibodies targeting the extracellular domain, the intracellular domain, and the phosphorylated isoform in a series of 11sinonasal intestinal-type adenocarcinomas tissues. EGFR, KRAS, and BRAF mutational status were detected by DNA direct sequencing and Melt curve method.RESULTS The findings were analyzed with respect to clinical data, histological typing, and outcome of the patients. EGFR was expressed in 72.7% tumors with a focal distribution with both extracellular domain and intracellular domain, which showed a significantly correlation. p-EGFR was expressed in 9.1% tumors. 9.1% tumors had the mutation of EGFR gene in exon 19, 9.1% tumors had the mutation in exon 2 and exon 15 of gene KRAS and BRAF respectively. There was no association between these molecular features and the survival period of the patients. CONCLUSION The current study revealed various EGFR expression patterns in sinonasal intestinal-type adenocarcinomas, that indicated the tumor heterogeneity. Sinonasal intestinal-type adenocarcinomas share common alterations of the EGFR pathway as the mutation of EGFR, KRAS and BRAF genes, but with a lower frequency.

Objective To assess the efficacy and safety of propofol sedation for gastrointestinal endoscopy,we conducted a Meta-analysis of randomized controlled trials (RCT) comparing propofol with traditional sedative agents.Methods Referring Cochrane Collaboration search strategy to develop retrieval in Medline,Web of Science,Wanfang and CNKI database to retrieve the anesthetic propofol and traditional agents in the literature for randomized controlled trials of gastrointestinal endoscopy,surgery and assess their recovery effect.Results Twenty-one original RCTs investigating a total of 1 765 patients,of whom 894 received propofol only and 871 received traditional sedative agents only,met the inclusion criteria.Research showed that compared with traditional anesthetics,no significant differences existed in anesthetic effects of propofol on gastrointestinal endoscopy surgery time.However,surgery can significantly shorten recovery time and the average discharge time; and higher recovery rates.The result of racial subgroup analysis showed:the anesthetic propofol can significantly shorten the time of gastrointestinal endoscopy surgery for Asian populations,but had little effect on the European population.Contrast method for subgroup analysis showed:anesthetic propofol could significantly shorten the ERCP angiography in gastrointestinal endoscopy surgery time,but has little effect on the UGE and colonscopy angiography.Conclusions Propofol is safe and effective for gastrointestinal endoscopy procedures and is associated with shorter endoscopy recovery and discharge time,higher post-anesthesia recovery scores.Care should be taken when extrapolating our results to specific practice settings and high-risk patient subgroups.

Melanoma is the most aggressive and lethal malignant tumor in skin cancers. Operation resection is used to treat stageⅠ/Ⅱmelanomas, but traditional operation, chemotherapy, and radiotherapy inflicts adverse effects on late-stage melanomas. StageⅢ/Ⅳmelanomas are some of the most ineffectively treated tumors with poor prognosis. As a cancer treatment, targeted immunotherapy in-hibits negative regulatory factors and enhances systemic anti-tumor immune effects. Radiotherapy not only kills tumor cells, but also en-hances systemic immune responses. Recent studies showed that targeted immunotherapy combined with radiotherapy can promote con-trol on local and distant tumors and prolong overall survival. The synergistic effects of these two therapies are superior to a single thera-py. This review summarized the progress on these research fields.

Objective To investigate the therapeutic measures of unresectable primary liver cancer (PLC) with transcatheter arterial chemoembolization(TACE).Methods The clinical data,treatment measures and followed up data of 312 patients with unresectable primary liver cancer from January 1991 to March 2010 were analyzed retrospectively.Of these 312 patients, different dosages, measures of transcatheter arterial chemoembolization together with immunotherapy and nutritional support treatments were given to the patients according to their own statements, including the patency of portal vein (evaluated by portography), the range, blood supply and lipiodol concentration of the lesions (evaluated by hepatic arteriography), and the systemic conditions.Some of these patients also accepted cryotherapy, radio frequency ablation (RFA), percutaneous ethanol injection therapy.Results Two hundred and eighty-seven patients were followed up (92％).Forty-two cases accepted the two-stage operation as the lesions were localized or reduced.In these 42 patients, 34 cases accepted the hepatectomy, 8 cases accepted the cryotherapy.The 1,3 and 5 year survival rate of all patients were 87.6％, 33.1％ and 13.2％.Conclusion TACE for unresectable primary liver cancer should be used individually and comprehensivly.Surgical treatment should be taken once the lesions can be resected.

[Summary] Radical prostatectomy, external beam radiation and active surveillance are the main treatments for localized prostate cancer. However, many patients are difficult to accept the psychological burden of active surveillance and the distress caused by potential side effects of radical therapy, including incontinence and erectile dysfunction, which make them limited. With the development of minimally invasive techniques, such as brachytherapy, cryoablation, high-intensity focused ultrasound, photodynamic therapy, and irreversible electroporation, novel procedures are playing an increasingly important role in the treatment of localized prostate cancer with their effective, minimally invasive, and safe advantages. This article mainly reviewed the above several minimally invasive treatment methods.