Objective To assess the efficacy and safety of tranexamic acid (TXA) in decreasing operative blood loss and the need for transfusion during posterior spinal fusion for the treatment of idiopathic scoliosis in adolescents. Methods A retrospective comparative analysis of 93 consecutive adolescents undergoing posterior spinal fusion procedures was per?formed. Patients were divided into treatment group (TXA, n=43) and control group (n=50). Clinical indicators were compared in operation and after operation between two groups. Results There was significantly less operative blood loss (703±176) mL in TXA group than that of control group (1143±389) mL. And post operation flow was also lower in TXA group than that of control group [(145 ± 75)mL vs (278 ± 95) mL, P<0.001)]. Autologous blood recovery in patients was lower in TXA group than that of control group [(241.0±109.1) mL vs (372.7±123.0) mL, P<0.001). There were no major intraoperative complica?tions in two groups. There was no blood transfusion in TXA group, and there was 1 case with 400 mL blood transfusion in con?trol group. Conclusion TXA treatment can decrease blood loss and blood transfusion and not increase intraoperative and postoperative complications in surgery of posterior spinal fusion of adolescent idiopathic scoliosis.

Objective To analyze the epidemiological data on air particulate matter and adverse health outcomes in China, and to estimate the exposure_response relationships. Methods An electronic search of relevant literature was conducted to determine the exposure_response relationship for each health outcome associated with exposure to air particulate matter, and the approach of Meta_analysis was used when there were several studies describing the same health endpoint. Results For each health outcome from morbidity to mortality changes, the relative risks were estimated when the concentration of air particulate matter increased some certain units. Conclusion The exposure_response relationships described here might be further applied to health risk assessment of air particulate matter in China.

Humans ; Percutaneous Coronary Intervention ; Propensity Score

Objective To get comprehensive and quantitative evaluation of the impact of ambient air pollution on human health. Methods The approach recommended in this paper is a quantitative estimate on the health impact from exposure to air pollutants based on the internationally accepted quantitative risk assessment framework and the per unit increase in mortality or morbidity due to per unit increase of air pollutants levels. Results A schematic diagram of health-based risk assessment on air pollutants is presented. Calculation for excess deaths and excess disease cases is also provided. Conclusion This approach could be used for comparing the health effects associated with exposure to air pollutants of various Chinese cities in different time periods and is also useful in the priority setting of air pollution intervention and improvement measures and health-based cost benefit analysis.

Objective To evaluate the incidence of contrast-induced nephropathy(CIN)in non-selected patients undergoing coronary angiography and intervention,and to investigate,the clinic risk factors of CIN as well as the renal safety of isosmolar iodixanol.Methods A total of 532 patients undergoing diagnostic coronary angiography or percutaneous coronary intervention were enrolled.Serum creatinine(SCr)was measured at any time within a week before the procedure and 2 days(48 hours)post procedure.The definition of CIN is the increase of serum creatinine of 44.2 ?mol/L(0.5 mg/dL)or 25% of the baseline at 48 hours after the use of contrast media.The effects of contrast media on renal function in patients undergoing coronary intervention were investigated and predictors of CIN were determined using logistic regression test.Results(1)Among the 532 patients,CIN occurred in 29 patients and the incidence of CIN in non-selected patients was 5.5%.(2)The incidence of CIN was significantly higher in patients with baseline eGFR

Objective To investigate the clinical efficacy of acupuncture at Hegu plus Fuliu in treating hyperhidrosis in Parkinson’s disease. Methods Fifty-seven Parkinson’s disease patients with hyperhidrosis were randomly allocated to a treatment group of 28 cases and a control group of 29 cases. The control group received conventional acupuncture and the treatment group, acupuncture at Hegu plus Fuliu in addition. The VAS score and the HDSS score were recorded in the two groups before and after treatment. The clinical therapeutic effects were compared between the two groups.Results There were statistically significant pre-/post-treatment differences in the VAS score and the HDSS score in the two groups (P<0.01). There were statistically significant post-treatment differences in the VAS score and the HDSS score between the treatment and control groups (P<0.01). The total efficacy rate was 96.4% in the treatment group and 72.4% in the control group; there was a statistically significant difference between the two groups (P<0.05).Conclusion Acupuncture at Hegu plus Fuliu can effectively reduce hyperhidrosis in Parkinson's disease patients.

Adenocarcinoma, Mucinous ; pathology ; Adult ; Breast Neoplasms ; metabolism ; pathology ; surgery ; Carcinoma ; pathology ; Carcinoma in Situ ; metabolism ; pathology ; surgery ; Carcinoma, Ductal, Breast ; metabolism ; pathology ; surgery ; Diagnosis, Differential ; Female ; Fibrocystic Breast Disease ; metabolism ; pathology ; surgery ; Humans ; Hyperplasia ; Lactalbumin ; metabolism ; S100 Proteins ; metabolism

strains of fast-growing rhizobia isolated from Chinas western (mainly from Qinghai province),and 4 representative strains were compared by performing numerical taxonomy. 132 phenotypic characteristics were analyzed. The results of numerical taxonomy constructed a dendrogram. It shows that all the strains examined clustered into five phena at a similarity level of 79%. 16S rDNA PCR-RFLP were applied to 57 rhizobial strains (among the 61 strains) and 10 reference strains. The 16S rDNA-RFLP analysis described 20 different genotypic characteristics and form one dendrogram. For some large groups, the results of 16S rDNA-RFLP were agreement with that of numerical analysis of phenotypic characteristics.

Retinitis pigmentosa (RP) is a large group of common hereditary eye diseases with highlyheterogeneous genetic background. Over forty genes with diverse functionalities are associated with RP and they include a set of ubiquitously expressed genes. These include five genes involved in the precursor messenger RNA( premRNA) splicing. Recent progress in disease gene identification for RP has established the involvement of pre-mRNA splicing as one important mechanism in the disease etiology and has shed light on the splicing process itself, a fundamental biological process. To this date, studies in this field have been focused on two major issues. First, how do the mutations of the adRP associated splicing factors (adRP-SF) affect the splicing function? Second, how do the mutations in these ubiquitously expressed genes lead to specific retinopathy? The two topics fit with the two continuous important steps of the disease pathogenesis. Recently, researchers have made a dramatic progress in the first topic. The identification of the SNRNP200 gene,the fifth adRP-SF and its relevant functional study has shown significance to the progress in the study of RP. Numerous investigations are also being carried out in addressing the second issue.Generation of a variety of models led to a better description of the pathological process of the disease. However, in respect to the key pathogenic mechanism,researchers are still puzzled with a number of confusing questions. In this commentary,the results from the latest investigations were summarized, and in particular,the difficulties in studying the molecular mechanism by which the pre-mRNA splicing deficiency causes RP were detailed.

Glenohumeral subluxation is one of the most frequent complications in patients with post-stroke hemiplegia. This paper reviewed the recent advances in research on post-stroke Glenohumeral subluxation from the epidemiology, pathogenesis and related factors, diagnosis,treatment and so on.