Lysine specific demethylase 1( LSD1) is a kind of flavin adenine dinucleotid ( FAD) dependent amine oxidase and can specifically demethylate H 3K4me2/me1 and H3K9me2/mel, thus it can regulate gene transcriptional activity .LSD1 is essential for mammalian development and is involved in many biological proces-ses,including cell differentiation,gene activation,and gene repression.Nowadays,it is demonstrated that LSD1 might promote cell phase transition(deficiency in LSD1 leads to partial cell cycle arrest in G2/M)and cell prolif-eration,suggesting that the over -expression of LSD1 might promote tumorigenesis.LSD1,as a demethylase,may be a new target for anti -cancer therapy.Hereby,we review on the structure,action mode of LSD1 and its rela-tionship with oncogenesis .

Objective:To investigate the diagnosis value of Color Doppier Flow Imaging in the clinical application.Methods:Applying color doppier flow imaging was applied to 68 cases of hypertension.The carotid intima-media thickness,the intima-media thickness(IMT),RI,etc.were measured.The results wese compared with the figures healthy people of the same age.Results:The figures showed great difference,the blood vessel diameter and IMT of the patients aere obviously thicker than those of the healthy group(P

Objective To observe the changes of electroneurogram in patients with diabetic peripheral neuropathy(DPN).Methods The electroneurophysiological data of 78 patients with DPN,including motor nerve conduction velocity(MCV),sensory nerve conduction velocity(SCV) and F-response,were observed.Results Among the inspected 468 nerves of 78 patients with DPN,166 nerves' MCV were slowed down,and 39 nerves with the decrease of MCV were accompanied by the prolongation of distal delitescence.The abnormality rate was 43.8%.175 nerves' SCV were also reduced,75 nerves were tested with no potential elicited,and 26 nerves with the decrease of SCV were accompanied by the prolongation of distal delitescence.The abnormality rate was 58.9%.The F-waves of 66 nerves(64.7%) in 102 tested nerves were abnormal,and 12 nerves' F-wave time chronodispersion(11.8%) increased.Conclusions Electroneurogram is a sensitive and characteristic inspection in the diagnosis of DPN,and the diagnostic sensitivity may be improved if multiple parameters are used together.

Objective:To investigate the clinical effect of Six Ingredient Rehmanuia Decoction variation and cortial hormone for autoimmune hepatitis. Methods: 60 patients with autoimmune hepatitis were divided into two groups: the treatment grouup(30 cases) and control group(30 cases). Both the treatment group and control group were given methyl prednisolone. The treatment group was treated with hormone with the additon of Six Ingredient Rehmanuia Decoction, etc., one packet a day. The treatment courses of two groups were all 8 weeks. Results: The treatment group was superior to the control group in symptom, liver function and improvement of immune function. Conclusion: Six Ingredient Rehmanuia Decoction and a small dose of cortical hormone is effective for autoimmune hepatitis. No side effect is observed.

As an inevitable outcome of industrialization and modernization,fashion has already underlined and comprised our daily life.No matter it is fashion of substances,concepts or behaviors,all of them are crashing against the traditional ethics value system.Its unique characteristic tries to overthrow the traditional behavior mode and cognition mode,reflecting individual's abnormal sense of value.Fashion is a two-blade sword.On the one hand,it brings both society and individuals with positive ethical effect.On the other hand,it also leads to the popularity of consumerism,corroding people's spiritual world.Morality can be used as a guide and model of fashion,and fashion can also be used for decorating morality.To avoid dull preaches is the key to balance the mutual relationship between morality and fashion.

AIM:To compare and analyze the effect of recombinant bovine basic fibroblast growth factor ( bFGF ) eye drops and hydroxyl indican eye drops on the tear film stability and dry eye symptoms after age-related cataract surgery. ·METHODS: A total of 115 patients ( 115 affected eyes ) with dry eyes after age-related cataract surgery were divided into the bFGF group, the hydroxyl indican group and the blank control group by the random number table method. The blank control group was only given routine anti-inflammatory treatment, and on the basis, the bFGF group and the hydroxyl indican group were treated with bFGF eye drops and hydroxyl indican eye drops respectively. The clinical efficacy, adverse reactions, changes in scores of dry eye symptoms, Schirmer test ( SⅠt) , tear film break- up time ( BUT ) and corneal fluorescein staining ( CFS) scores at different time points were compared among the three groups. ·RESULTS:The total markedly effective rates in the bFGF group ( 89. 5%) was higher than that in the hydroxyl indican group ( 70. 3%) or the blank control group (47. 5%) (P<0. 05). Scores of dry eye symptoms, CFS, SⅠt and BUT in the three groups at 2 and 5wk after surgery were significantly different (P<0. 05). The above-mentioned indexes in the bFGF group at 2 and 5wk after surgery were significantly better than those in the hydroxyl indican group and the blank control group, and better in the hydroxyl indican group than the blank control group ( P < 0. 05 ). There were no obvious adverse reactions. ·CONCLUSION: The tear film is unstable in early stage after age-related cataract surgery, and there are dry eye symptoms. The intervention with bFGF eye drops and hydroxyl indican eye drops can effectively restore the tear film stability and significantly relieve dry eye symptoms, and the effect of bFGF eye drops is more significant.

Objective To study the change and its application of the brain stem auditory evoked potentials (BAEP) in language -impaired children. Methods We used evoked potentials Denmark Wedy Keypoint device to analysis the BAEP test results of the 79 cases of children in our hospital from August 2006 to December 2008. Rsults The total rate of BAEP abnormalities in children was 64.6% , of which 15.7% for one of the bilateral BAEP wave disappeared, 11.8% for the unilateral BAEP wave disappeared with the other side of the wave being abnormal BAEP,and 72.5% for the wave latency (PL) and wave interphase (IPL) abnomal. Conclusion BAEP is a sim-ple, noninvasive, threshold stability, results reliable and reproducible method of examination. For language -impaired children of hearing damage and abnormal neural pathway ,it can provide valuable objective indicators.

Objective To evaluate the clinical value of plasma procalcitonin and D-dimer measurements in estima-ting the prognosis of patients with sepsis.Methods According to prognosis,68 patients with sepsis were divided in-to survival group and death group,levels of procalcitonin and D-dimer,and acute physiology and chronic health eval-uation II (APACHE II)of two groups of patients were compared,predictive value of above markers in estimating the prognosis of patients with sepsis were evaluated.Results Of 68 patients with sepsis,28 survived and 40 died, mortality was 58.82%.There were significant differences in levels of procalcitonin and D-dimer,as well as APACHE II between two groups(both P<0.05),death group were all higher than survival group.Procalcitonin and D-dimer level were positively correlated with APACHE II score(P<0.05).Conclusion Procalcitonin,D-dimer level and APACHE II score can be used to evaluate condition of patients with sepsis as well as the prognosis of dis-ease.

The introduction of research study in the course of biochemical engineering is discussed in the essay both in theory teaching and practice period to cuhivate the students'ability of self-development and innovation

OBJECTIVE:To discuss about the development strategy of pharmaceutical enterprises in our country in the new century.METHODS:To expound the developing strategy that domestic pharmaceutical enterprises should adopt in respect to technical innovation,development of product,exploitation of market,human capital and enterprise culture.RESULTS & CONCLUSION:Facing the new management environment,the pharmaceutical enterprises in our country should achieve new breakthrough in development strategy to adapt to trend of the times,grasp opportunity and face challenge.