Objective:To discuss the curative effect of atorvastatin intensive treatment on lipid-lowering in the patients with type 2 diabetes and its influence on vascular endothelial function. Methods: Totally 74 cases of patients with type 2 diabetes were selected and divided into the intensive group ( n=37 cases) and the ordinary group ( n=37 cases) at random. The patients in the two groups were given routine medical treatment, such like diet adjustment, moderate exercise and drug control etc, and the patients in the inten-sive group were additionally given 40 mg atorvastatin orally, once a day, while the patients in the ordinary group were additionally given 20mg atorvastatin orally, once a day for 12 weeks. The changes of blood fat, von willebrand factor (VWF) of serum vascular endothe-lial function, plasma thrombomodulin ( PTM) and vascular endothelial cadherin ( VEC) levels of the patients before the treatment and in the 12th week after the medical treatment were observed and compared, and the adverse drug reactions ( ADR) were evaluated as well. Results:After the 12-week medical treatment, TC, TG and LDL-C levels of the patients in the two groups were obviously de-clined than those before the treatment, while HDL-C levels were obviously raised than those before the treatment ( P<0. 05 or P<0. 01), and the changes in the intensive group was more notable than those in the ordinary group (P<0. 05). Meanwhile, serum VWF, PTM and VEC levels were obviously declined than those before the treatment (P<0. 05 or P<0. 01), and the declining rate in the intensive group was much higher than that in the ordinary group (P<0. 05). Totally 2 and 4 cases of untoward effect appeared re-spectively in the ordinary group and the intensive group with light symptom, and the incidence of ADR showed no statistical difference between the two groups (P>0. 05). Conclusion:Compared with atorvastatin, atorvastatin intensive treatment in the patients with type 2 diabetes has more favorable lipid-lowering effect, which can effectively reduce serum vWF, PTM and VEC levels to improve and rem-edy vascular endothelial function with high security.

0.05). Conclusion It has good therapeutic effect to treat children FRAP with mental intervention and Chinese drugs.

The super severe combined immunodeficient mice(superscid)is a newly established mouse strain which was constructed by introducing the bg gene into C.B-17 scid mice.To identify its cellular immunologic haracteristics,we examined the T、natural killer(NK)and lymphokine-activated killer (LAK)cell activity in this mouse strain.The NK cell activity was studied by measuring the cytotoxicity to NK sensitive cell(YAC-1)and the influence of poly Ⅰ-C on it.The LAK cell activity was examined by measuring the cytotoxicity aganist NK resistant cell(p815).The spleen cells of B.C.B-17 scid-beige mice lacked responsiveness to a T cell mitogen (concanavalin A 5?g/ml,600.004?207.84cpm,266.67?29.84cpm for scid mice,p0.05);showed a low LAK cell activity(6.40?6.9 for B.C.B-17 Scid-beige mice,vs 72.3?14.1% for C.B- 17 scid mice at IL-2 250u/ml;E/T 00:1,3 days,P

It's ethically important for doctor and patient to adopt onus proof of conversion,the ethical vice of which makes the hospital be potential accused,who will always take over treatment for self-protect.From the view of onus proof of conversion,to eradicate overtreatment,it's a must for medical to understand onus proof of conversion,the treatment organization to enhance management to improve the doctors's professional ethics,society to recognize the high risks of medical,establish and perfect the insurance system of doctors.

The construction of a harmonious physician-patient relationship.The perfection of healthcare system by local government and construction of systematic ethics serve as the premise.The enhancement of physician-patient relationship management by hospitals,the improvement of medical service,medical ethics instruction,and the systematic construction of physician-patient communication are key steps.The reform of medical treatment assessment,setting up of the third-party mediation institution,and the strengthening construction of public opinion direction are important conditions.

The value of ethics in law enforcement and the dialectical relationship between moral obligations and legal obligations determine that default is a legal judgment,and meanwhile an ethical judgment.In the context of informed disconsent,medical default could be resulted from the distorted roles of medical staff by the tensional physician-patient relationship,defects in the informed consent system,and the insufficient protection for the high-risky medical treatment.Therefore,it is in urgent need to strengthen the professionalism construction among medical staff,fully develop the function of hospital ethics committee,and continuously perfect relevant legislations.

Objective To investigate the efficacies of irbesartan(Irb)in decreasing the 24 hour microalbuminuria(MA)and treating early diabetic nephropathy in the normotensive aged patients.Methods forty-eight normotensive aged patients with the early diabetic nephropathy(24 hour urinary albumin excretion rate within range(20～200?g/min)were divided randomly into two groups: the Irb group(28 cases)and control(C)group(20 cases)were respectively administered with Irb(75～150mmg/d)and placebo. The two group patients were treated with oral antihyperglycemic agents or/and insulin till their fasting blood glucose(FBG) value ≤7 0mmol/L and postprandial 2 hour blood glucose(2hBG) level ≤10 0mmol/L.The MA, systolic and diastolic pressure(SBP and DBP), serum creatinine(Cr)and uric acid(UA)and potassium(K +) levels were examined before and after the treatment(at the 12 th wk and 24 th wk).Results After treatment ,the MA of the Irb groups was significantly decreased(P

Bribery in Pharmaceutical field is just an injustice trade.It appears that not only has individual moral weakening,the miss of hospital management,but also has incompletion of social supervision.To harness the business bribery,solve the problem of difficult and high cost of getting medical service,we should take all kinds of measures,such as to strength the professional moral education and complete the personality of medical personnel,to regulate the ethical construction of hospital reformation in health system,to strength the building of social morality and law.

OBJECTIVE:To provide reference for the professional entrance and management of professional titles of pharmaceutical technicians.METHODS:The regulations on the professional entrance and management of professional titles of pharmaceutical technicians in China and the problems involved were analyzed binding with the actual situations in Guizhou.RESULTS & CONCLUSIONS:The problems included medical institutions' failure in emphasizing the qualification of pharmacists,indiscrimination of the licensed pharmacists of related specialties,the incompleteness in item design for the certificate of licensed pharmacists,and the training of licensed pharmacists laid focus only on quantity rather than quality.It is advisable to strengthen professional entrance for pharmaceutical technicians and adopt a classified management on licensed pharmacists.

OBJECTIVE: To study the status quo of the use of protein anabolic preparation and peptide hormone in our hospital and to strengthen the standardized management on drug use.METHODS: The protein anabolic preparation and peptide hormone used during Jan 2004～Dec 2007 in our hospital were analyzed statistically in respect of the consumption sum and the drug variety.RESULTS: The protein anabolic preparation totaled 4 kinds and peptide hormone 3 kinds.The consumption sum of protein anabolic preparation plus peptide hormone accounted for about 1% of the total,of which,peptide hormone took a higher proportion.CONCLUSIONS: Both the variety and consumption sum were on the lower side for protein anabolic preparation and peptide hormone used in our hospital,the management of which was standard on the whole;however,there are some defects and the management on the use of those drugs should be intensified.