Bilateral sequential cataract surgery is very common in clinical,but the ophthalmologists often ignore how to choose the timing of operation and whether the first eye can be used to improve the intraocular lens (IOL) power calculation for the second one.Despite the refinements in IOL selection with the use of third-generation IOL formulas,5％ of eyes still result in a postoperative refractive surprise of ± 1.00 D or more.This paper introduced the methods of using refraction error of the first eye to improve the IOL power calculation for the second eye,and the refractive error of the second eye can be improved by modifying the IOL power to correct up to 50％ of the error from the first eye in details.Because of the variation of the postoperative refractive surprise within a month,the interval of three to four weeks between two eyes cataract surgery is highly recommended.These conclusions may provide the advantageous guidance for us in the selection of IOL in bilateral cataract surgery.

OBJECTIVE: To characterize the pharmacokinetics of a single dose of 2.5 mg fondaparinux sodium in Chinese patients after thoracic surgery. METHODS: Thirteen patients were enrolled in the study and were given a single dose of 2.5 mg fondaparinux sodium via a subcutaneous injection. Plasma concentrations of fondaparinux sodium were measured throughout a 24 h period. The pharmacokinetic analysis was performed using WinNonlin software. RESULTS: The following pharmacokinetic parameters were derived; t1/2(7.92 ± 3.13) (4.21-15.89) h, tmax(2.52 ± 0.93) (1.38-4) h, p-1 (0.73 ± 0.18) (0.45-1.02) mg · L-1, AUClast(6. 56 ± 2.19) (3.07-9. 75)mg · h · L-1, Vz/F(3.54 ± 1.00) (2.24-5.73) L, CL/F(0.34 ± 0.14) (0.16-0.63) L · h-1, and MRTlast (6.98 ± 2.1) h. The pearson correlation coefficient, r was 0.7283(P = 0.005) between the serum creatinine(Scr) and mean residence time(MRTlast) of fondaparinux. CONCLUSION: The disposition of fondaparinux is highly variable in patients. A statistical significant correlation between Scr and MRTlast of fondaparinux was observed. Fondaparinux sodium administered by intravenous injection is well tolerated in patients.

Research on CellSearch system's detection rate of cells and linearity performance detection method, so as to analyze the accurate and reasonable detection method to meet the CellSearch characteristics of the system.
Biomarkers, Tumor ; Cell Line, Tumor ; Cell Separation ; methods ; Humans ; Neoplastic Cells, Circulating

The microarray technology used in biological and medical research provides a new idea for the diagnosis and treatment of cancer. To find different types of cancer and to classify the cancer samples accurately, we propose a new cluster ensemble framework Dual Neural Gas Cluster Ensemble (DNGCE), which is based on neural gas algorithm, to discover the underlying structure of noisy cancer gene expression profiles. This framework DNGCE applies the neural gas algorithm to perform clustering not only on the sample dimension, but also on the attribute dimension. It also adopts the normalized cut algorithm to partition off the consensus matrix constructed from multiple clustering solutions. We obtained the final accurate results. Experiments on cancer gene expression profiles illustrated that the proposed approach could achieve good performance, as it outperforms the single clustering algorithms and most of the existing approaches in the process of clustering gene expression profiles.
Algorithms ; Cluster Analysis ; Gene Expression Profiling ; methods ; Humans ; Neoplasms ; genetics ; Transcriptome

We learn the advanced philosophy and methods in dermatology residency standardized training program by introducing the residents matching system,periodical training programs and evaluation mechanisms in Taiwan.With the knowledge of current dermatology residency training system in mainland China,we give some recommendations to how to improve dermatology residency standardized training system in mainland China:standardizing and improving dermatology residence recruiting metrics,preparing effective training plan,and implementing better candidate evaluation processes as well as providing a strong faculty team.

Discovery of noncoding RNA(ncRNA)over the past decade has reflected a paradigm shift of traditional RNA research. There is evidence that RNA can function not only as a messenger between DNA and protein,but as a regulator of genome organization and gene expression,which is increasingly elaborate in complex organisms. ncRNA seems to operate at many levels,however,in?cluding the physiological and pathological status. The research of ncRNA in pharmacology has not been summarized before. Here,we reviewed the emergence of the ncRNA in the research of pharma? cology,such as acting as biomarkers and medical targets. Besides,we mentioned their role in drug resistance and drug addiction in order to highlight the significant role of ncRNA in pharmacology.

Diabetic retinopathy (DR) is a common cause of blindness,its occurrence and development are the synergic results of multiple factors.Current studies suggest that inflammation and inflammatory factor has an important role in the pathogenesis of DR.The occurrence and development of DR are closely related with interleukins,intercellular adhesion molecules,hasten factors,tumor necrosis factor,C-reactive protein etc.Mesenchymal stem cells (MSCs) are pluripotent cells derived from the mesoderm and have multiple differentiation potentials,and anti-inflammatory and immunosuppressive function.Recent studies shown that MSCs transplantation can protect damaged retina by inflammatory regulation,which become a new research direction for DR treatment.

Chemotherapy is one of the main treatment methods in malignant tumor.Tumor multidrug resistance (MDR) is one of the important reasons for the failure of chemotherapy.It makes some progress in reversing tumor MDR,such as chemical drug,traditional Chinese medicine,immunotherapy,gene therapy,nanoparticles drug system and so on.But it takes more effort to develop medicine of less adverse reactions,better pharmacodynamic and application to clinic widely.

Adjuvant therapy of breast cancer in the child-bearing period tends to affect ovarian function of patients.Adjuvant chemotherapy has a great damage for ovarian function,and tamoxifen's extent of the damage is not yet clear,but gonadotropin-releasing hormone (GnRH) has a protective effect on ovarian function.In the adjuvant therapy,synthetic weigh the pros and cons,make the best individualized programs,is the future direction of the treatment of breast cancer.

Layered anatomy is a both ancient and novel conception, which is derived from topographic anatomy.Topographic anatomy and phylembryogenesis are basic academic knowledges of layered anatomy.With the development of laparoscopic surgery and robotic surgery, less bleeding, more meticulous dissection, faster postoperative recovery and lower recurrence rate are required in surgical operation, because of which layered anatomy is mentioned and valued again.Organs in abdominal cavity are composed of different layered tissues,between them are loose connective tissues which are poor in vessels.Layered anatomy in surgical operation can avoid the en bloc dissection of organs, which not only reach total lesion dissection, but also avoid hurting surrounded normal tissues, showing the best surgical results.