Child ; Child Behavior Disorders ; etiology ; Cognition Disorders ; physiopathology ; Humans ; Sleep Apnea Syndromes ; psychology

Uncoupling protein 2(UCP2)is a proton transporter which presents in the mitochondrial inner membrane. Recent studies have found that UCP2 plays important roles in protecting mitochondria functions,re-ducing mitochondrial ROS generation by inducing proton leak across the inner mitochondrial membrane and pro-moting mild uncoupling which leading to a decrease in the mitochondrial inner membrane′s potential. Because of its antioxidant function,UCP2 has been studied in several domains. This review provides novel insights into the molecular mechanisms,by which the activity of UCP2 is regulated and describe novel findings concerning basical experiments of UCP2.

Forty patients with hip disease who underwent first total hip arthroplasty (THA) in Department of Orthopedics, Second Hospital of Chongqing Medical University from January 1999 to January 2002 were selected. They were treated with cemented (n =16) and cementless THA (n =24). The time to leave bed of cemented-THA group was obviously shortened compared with cementless THA group (P

Objective To summarize the incidence, diagnosis, treatment and prognosis of patients with hemolysis, elevated liver enzymes and low platelet count (HELLP) syndrome. Methods The clinical data of fourteen cases with HELLP syndrome complicated by severe pregnancy-induced hypertension were analyzed retrospectively during the past seven years. Results The incidence of HELLP syndrome was 8% in the patients with severe pregnancy-induced hypertension. According to the diagnosis criteria used by Tennessee University, there were eight cases with complete HELLP syndrome and six cases with partial HELLP syndrome. The major therapeutic way were intensive maternal and fetal monitoring, active management of preeclampsia and eclampsia, administration of corticosteroids and termination the pregnancy as fast as possible. The major complications were DIC, placental abruption, pneumonedema and acute renal failure. The maternal and perinatal mortality were 7% and 29%, respectively. Conclusions HELLP syndrome was a serious life-threatening complication of severe pregnancy- induced hypertension. In order to decrease the maternal and perinatal mortality rate, HELLP syndrome should be diagnosed and treated as fast as possible.

Objective To explore the effects of DU meridian electroacupuncture on the survival,differentiation and immigration of neural stem cells(NSCs) transplanted in the injured site of rat spinal cord transection. Methods Twenty adult SD rats were divided into NSCs transplanted 14d group(NSCsl4d group),DU meridian electroacupuncture plus NSCs transplanted 14d group(EA+NSCs14d group),NSCs transplanted 30d group(NSCs30d group) and DU meridian electroacupuncture plus NSCs transplanted 30d group(EA+NSCs30d group).T10 spinal cord segments of all animals were completely transected.The rats of EA+NSCs14d group and EA+NSCs30d group were treated with DU electroacupuncture at 5 days after operation.The sacrifice times of the rats were respectively at 14 days and 30 days after operation.The spinal cords were taken for observing the survival,differentiation and immigration of neural stem cells transplanted in the injured site of rat spinal cord transection. Results 1.The surviving number of transplanted NSCs in EA+NSCs14d group or EA+NSCs30d group was more than that of NSCsl4d group or NSCs30d group,and the surviving number of transplanted NSCs in EA+NSCs30d group and NSCs30d group was less than that in EA+NSCs14d group and NSCs14d group.2.Some transplanted NSCs at injured site of transected completely spinal cord and neighboring tissue showed microtubule association protein 2(MAP2) positive staining in EA+NSCs30d group or NSCs30d group.3.Many transplanted NSCs at injured site of transected completely spinal cord and neighboring tissue could be observed to show glial fibrillary acidic protein(GFAP) positive staining in EA+NSCs 30d group or NSCs 30d group.4.The immigrating distance of transplanted NSCs toward caudal tissue of injured site of spinal cord was longer in EA+NSCs 14d group and EA+NSCs 30d group than that in NSCs 14d group and NSCs 30d group.Conclusion DU meridian electroacupuncture may promote the survival of neural stem cells transplanted in injured site of rat spinal cord transected completely,and these cells can differentiate into MAP2 or GFAP possive cells.DU meridian electoacupuncture may affect the immigrating direction of neural stem cells transplanted at injured site of spinal cord toward host spinal cord tissue.

OBJECTIVE:To establish the preparation technique of Huoluoxiaoling pills METHODS:The optimun drying temperature and sterilization condition was obtained by screening RESULTS & CONCLUSION:The preparation technique is feasible and simple and the quality of product is stable

Zebrafish is widely used as a model organism in the process of drug discovery. It expresses drug metabolizing enzymes like cytochrome P450 (CYP450), uridine 5'-diphospho-glucuronosyltransferase (UGT) and nuclear receptors like pregnane X receptor (PXR), aryl hydrocarbon receptor (AHR), etc. This article summarized the profiles of main drug metabolizing enzymes and nuclear receptors, and reviewed the advances on xenobiotics metabolism in zebrafish.

3D ultrasound reconstruction in 63 cases of the solid space occupying lesions of liver was reported.Among them,there were 34 primary liver cancer,20 liver metastases and 9 cases hamangioma.By 30 imaging,the internal structure of the tumor could be visualized in 71%(45/63); the relation of the tumor to the surrounding vessels was apparent in 65%(41/63); the margin of the tumor could be outlined in 56%(35/63).The vesucts indicate that 3D ultrasound is superior to conventional 2D sonography to show more accurately the space localization,internal structure and morphology of the lesion thus provides meaningful imaging diagnostic evidences clinicaly.

This article reviews the major advances of basal and clinical research on the adrenal diseases at home and abroad from 2010 to 2012.There are many advances including the diagnostic value of steroidogenic factor-1 in adrenal tumors,the pathogenesis and new diagnostic methods of aldosterone-producing adenoma,the treatment for severe ACTH-dependent Cushing's syndrome,approach to the patient with an adrenal incidentaloma and subclinical hypercortisolism,screening test for subclinical hypercortisolism in the patients with diabetes or osteoporosis,the characterization of macronodular adrenocortical hyperplasia of the zona reticularis,as well as genetic testing for pheochromocytoma and paragangliomas,etc.

Objective To explore the correlation between HBV-DNA and serum HBV markers quantitative detection and determine its diagnosis value in hepatitis B virus infection. Methods The HBV-DNA was measured by fluorescence quantitative PCR and hepatitis B virus was detected by time-resolved fluorescence immunoassay (TRFIA). The relationship between the two tests was analyzed statistically using software. Results Detection of HBV-DNA in the peripheral blood of patients with HBsAg (+), HBeAg (+), HBcAb ( + ) showed 92. 9% (79/85) positive rate,and the average DNA copy number was (4.31 ± 1.64) × 106 copies/ml. While the detection of HBV-DNA in the peripheral blood of patients with HBsAg ( + ), HBeAb ( + ), HBcAb ( + ) showed 47.7% (105/220) positive rate, and the average DNA copy number was (2.47 ± 2. 21 ) × 104 copies/ml. In normal controls,blood HBV-DNA detection was negative. Furthermore, HBV-DNA copy number correlated positively with HbeAg quantitation (r = 0. 59, P = 0. 041 ). However, we found no significant correlation between HBV-DNA copy number and HbsAg quantititation (r = 0.221, P = 0.077). Conclusions Different HBV-M had diverse correlation with HBV-DNA number, comprehensive detection of them would be better to assist clinical diagnosis and evaluate the response to treatments.