For the recent 15 years, in order to change the business as new mechanism, the National pharmaceutical company No I has upgraded, perfected the technical basis, materials and facility, profession. In which the human resource was considered as a most important factor for the development and integration
growth & development ; Chemistry, Pharmaceutical

Species Da cam was identified as being Hedyotis capitellata Wall. Ex G.Don var. molis Piere ex Pit. It is used as a drug in traditional medicine. Primary results on our studies of Da cam have been presented that: the of Da cam contained alkaloid, saponin, iridoid, tanin. We have extracted and isolated from the leaves caulis of Da cam Sapogenin KLD3 and determinated it was Olanaolic acid
chemistry ; Hedyotis ; Pharmaceutical Preparations

Malumix, an antiacid uncoated tablet, contains Magaldrate as the biological active agent. Its optimal formula was established by using the artificial intelligent software CAD/CHEM 4.6, based on the experimental data of nine designed formulae. The experimental properties of the above dosage form were almost the same in comparison with its predicted ones.
Chemistry, Pharmaceutical ; Artificial Intelligence

Basing on common chemical reactions, thin layer chromato graphy, absouptive ultraviolet spectrum some parameters were determined for preparation containing benzodiazepine in HCM City. The efficiency of extraction of benzodiazepan in 6 self made sample: Rhino sweet drink, coca-cola, combined food, soya milk, 333 beer and urine. Results found 17 active substances of diazepine group in 131 specialities of commercial propriatary name in HCM City, where diazepam had accounted higher rate in narcotic intoxixation cases. In criminal cases involved in tranquillisant narcotics, the most common substance were diazepan, flunitrazepan, clonazepan, bromazepan, alprazolam, clorazepat, oxazepan and nor-diazepan
Benzodiazepines ; Pharmaceutical Preparations ; Chemistry

143 bacterial strains isolated in Vietnam for the cephalosporin C acylase activity. Among them, 116 strains showed growth on the LB plates containing cephalosporin and 28 strains did not grow. From 7 strains which grew very strongly on the LB plates containing cephalosporin C, 6 strains designated as 71, 91, DT3, M6, 03 and Tb23 were selected for further cultivation in the liquid culture medium and for determination of CA activity. The cell growth curves of these strain were very similar. The cell density reached a maximum at 24-30 hours of cultivation. Among three strains 71, DT3 and Tb23 evaluated for the CA activity, DT3 showed the highest CA activity. Thus, the strain DT3 was identified as Serratia marcescens sp. DT3. This is the first report about the Serratia strain producing CA enzyme
Pharmaceutical Preparations ; pharmacy ; chemistry

The chemical composition of Rhizoma Polygonati (RP) after processing was investigated. The result: All 4 process methods also procedure products no causing itch, black, sweet, soft, plastic. The chemical composition of unrefined Rhizoma Polygonati contained Alcaloid, Flavonoid, Sterol, Sugar, Iridoid glycosid, Amino acid and Fat. On the thin layer chromatograph, total alcaloid of Rhizoma Polygonati processed by a way had 4 spots, total flanoid had 4 spots, 1 spots of them cleare blue. The total sugar content of Rhizoma Polygonati processed by a way is 33,4% and of unrefined Rhizoma Polygonati is 12,63%. Both unrefined RP and processed RP also have 17 acid amin, among 7 essential acid amin for the body. The content of this acid amin of processed sample is usually higher than of unrefined sample
Chemistry ; Pharmacology ; Pharmaceutical Preparations

The root of Hedyotis capitellata Wall. ex G.Don var. mollis Piere ex Pit. Rubiaceae, has been investigated chemical constituents. The roots contained alkaloids, saponin, tannin, anthranoid. Of these, 3 compounds were purified and their IR,UV, EIMS, NMR spectra were determined and showed that: They were Hedyocapitine, Capitelline and Di- (2’- ethyl-1’-hexyl) phthalate (or1,2- benzenedicarboxylic acid, Di- (2’-ethyl-1’-hexyl) ester).
Chemistry ; Plant Roots ; Pharmaceutical Preparations

The formula of the skin cream containing the extracts of Centella asiatica (L.) Urb. and Curcuma longa L. - the two medicinal plants available in Vietnam – was established by means of experimental design and computer – aided optimization. At first, the formulae were designed by varying the amounts of their ingredients such as Polawax, cetostearyl alcohol, Tween 80 and Span. Then, the Oil-in-Water emulsion – type creams were manufactured by using the PUC VIKOSATOR emulsor. Next, the resulted products were evaluated for their physics – chemical parameters including the melting point, the extrudability and the number of the Oil particles. After that, the multiple – objective optimization was performed by the CAD/Chem artificial intelligence software, which is the unification of neural networks, fuzzy logic and genetic algorithms. At the end, the optimized formula was strictly evaluated by both hypothetical tests and experimental trials. In drug quality control, the investigation of skin cream was proven to meet its ointment requirements.
Cookery ; Chemistry ; Pharmaceutical ; Plants, Medicinal

The leaves of Blumea balsamifera DC Ha Giang was studied. The content of oils was determined by steam distiling method with improved oils quantitative instrument at Medicine Department of Ha Noi College of Pharmacy. The oils was analyzed by GC/MS. The result: The oils from leaves of Blumea balsamifera DC Ha Giang includes 29 components. The main components are: borneol 57,82%, beta-caryophylen 8,27%, denta-cadiol 7,95%, carryophylen oxid 3,1%, patchoulen 2,98%, veridiflorol 2,54% and 23 other components with content approximately 1%. Camphor only exist in the oils with content 1,12%. At Ha noi, 29 components and 18 components at Kak Mil was determined
Chemistry ; Medicine, Traditional ; Pharmaceutical Preparations

OBJECTIVETo optimize the process for preparing genipin with enzymolyzed geniposide by an orthogonal experiment.

METHODThe optimal enzymolysis process was selected by an orthogonal experiment, with the concentration of geniposide as the index as well as enzyme quantity, pH of enzymolysis solution, enzymolysis time and enzymolysis temperature as considerations.

RESULTThe optimal hydrolysis conditions were as follow: rough genipin samples at the concentration of 40 g x L(-1) were selected and shook on a table concentrator at a speed of 100 r x min(-1), added with beta-glucosidase-geniposide 1 : 1 (weight proportion), with pH of enzymolysis solution at 4.5, hydrolyzation temperature at 50 degrees C, the conversion rate of genipin could reach 85.8%.

CONCLUSIONThe process is so stable and feasible that it can provide theoretical basis for the preparation of genipin with enzymolyzed geniposide.