Introduction: Cigarette smoking is showing an increasing prevalence among university students nowadays. Smoking includes the act of smoking cigarette containing tobacco and/or other ingredients or just inhaling the cigarette smoke. Smoking has many known physical side effects that include psychological or cognitive effects. Therefore, the aim of this research is to identify the effect of cigarette smoking on the academic achievement among university students. Methods: A cross-sectional study was conducted among 136 students including 113 male and 23 female aged 18 to 29 years from Management and Science University with 30 non smoker students. The questionnaire included items about the social demographic characteristics, smoking status, the study styles and the academic achievement of the participants. A frequency statistics, descriptive statistics and chi square test were used to analyze the collected data using SPSS version 25. Results: Among the smoker students, 51.5% came to class early, 80.8% attend classes regularly, 49.3% studied on weekends and 39.7% planned sufficient time to study for exam. Mean CGPA for smoker students is 2.6. Conclusion: Smoking is proven to be associated with low academic performance among university student.