The preliminary pharmacodynamic studies of the preparation of artificial Fel Serpentis and Bulbus Fritiliariae Cirrhosae and Shedan Chuanbei San (composed of natural Fel Serpentis and Bulbus Fritiliariae Cirrhosae) were reported.The results showed that both of the above preparations could prolong the cough latency and decrease cough frequeucies induced by ammonia within 3 min,promote the excretion of respiratory tract,increase the excretion of phenol red and inhibit auricular edema induced by xylol in mice. Meanwhile, the above two preparations could also inhibit Ach-induced tracheospasm in vitro.Therefore,the replacement of natural Fel Serpentis with the artificial in the preparation of Shedan Chuanbei San is reasonable.