Objective To explore the value of ultrasound in assessment of treatment effect of diffuse toxic goiter.Methods 80 diffuse toxic goiter patients with 131I therapy were selected as research subjects.Before and after treatment,the serum thyroid hormone levels were detected and thyroids were checked by ultrasound.Results Before and after treatment,the FT3 levels were positively correlated with blood flow area ratio and flow grade (r =0.472,0.593,all P ＜ 0.05).After treatment,the thyroid weight,peak systolic velocity(PSV) and end diastolic velocity (EDV) [(12.89 ± 7.86) g,(32.24 ± 21.85) cm/s,(12.36 ± 19.22) cm/s] were significantly lower than those of before treatment [(30.12 ± 17.24) g,(68.58 ± 34.25) cm/s,(28.03 ± 21.24) cm/s] (t =11.265,4.762,3.672,all P ＜ 0.05).Before and after treatment,the RI and PI showed no significant difference(all P ＞ 0.05).The difference of thyroid blood flow grade before and after treatment was statistically significant (x2 =98.959,P =0.000),the proportion of flow grade class Ⅲ before treatment was higher(80.0％),while the proportion of flow grade class Ⅰ after treatment was higher(60.0％).After treatment,the FT3 and FT4 levels [(6.88 ± 4.14)pmol/L,(17.23 ± 7.35)pmol/L]were significantly lower than those of before treatment [(18.79 ± 6.45) pmol/L,(56.47 ± 22.97) pmol/L] (t =17.243,13.254,all P ＜ 0.05).The TSH level [(11.52 ± 8.27) mU/L] was significantly higher than that of before treatment[(0.01 ± 0.00)] mU/L (t =3.365,P ＜ 0.05).After treatment,the thyroid weight,PSV and EDV of cure group[(9.34 ±2.36) g,(20.13 ± 8.59) cm/s,(9.13 ± 5.34cmn/s)] were lower than those of non-cure group [(18.78 ± 8.76) g,(52.32 ± 13.24) cm/s,(17.24 ± 8.34crn/s)] (t =9.143,8.793,5.232,all P ＜ 0.05).The differences of RI and PI in the cure group and non-cure group were not statistically significant (all P ＞ 0.05).Conclusion Ultrasound has a better role in the evaluation effect of 131I therapy for diffuse toxic goiter.

Objective To study the character of cervical lymph nodes metastasis in nasopharyngeal carcinoma(NPC) by contrast-enhanced uhrasonography(CEUS) and time-intensity curve. Methods Forty-one lymph nodes of metastasis from 32 patients were studied by CEUS. The enhancement of echogenicity was evaluated,and the time-intensity curve was analyzed. Results Of the 41 lymph nodes examined, 10 (24.4%) showed intense homogeneous enhancement by CEUS, 23 (56.1%) showed inhomogeneous enhancement and 8 (19.5 %) showed scarce intranodal enhancement. There were 20 (48.8%) lymph nodes showed necrosis. Most of the lymph nodes (92.7%) showed peripheral type blood flow, 3 (7.3) % showed mixed type blood flow. There were significant differences in them(P < 0.01). The time-intensity curve displayed steeply in upslope, and gently in decent. The arrival time(AT), time to peak(TTP), peak intensity (PI) ,area and gradient were (7.2±2.5)s,(7.6±2.3)s,(9.5±3.3)dB,(203.4±45.7)dB· s,1.2±0.5 respectively. Between the lymph nodes with envelope infringed and not, there were significant differences in PI and area, while there were not significant differences in AT, TTP and gradient. Conclusions The metastasis cervical lymph nodes of NPC had specific character by CEUS and time-intensity curve. In this way,it may help us to diagnosis cervical lymph nodes metastasis of NPC,and provide more information for the therapy and prognosis judgement.

Objective To assess the value of blood perfusion of thyroid nodules using contrastenhanced ultrasonography(CEUS). Methods Blood perfusion parameters of 78 preoperative patients with thyroid nodule were examined using CEUS. Microvessel density(MVD) in the thyroid nodule specimens was calculated by immunohistochemical staining using anti-factor CD34. Results Compared to papillary thyroid carcinoma (PTC) and nodular goiter (NG), there was significant differences in peak value(PEAK),maximum value of video signal intensity(Slmax), and mean value of video signal intensity(SImean) in thyroid nodule with diameter ＜ 1 cm ( P ＜ 0. 05 ), the MVD of thyroid nodules was not statistically significant ( P ＞ 0.05). There were significant differences in regional blood volume and MVD in thyroid nodule with diameter ≥ 1 cm between two groups ( P ＜ 0.05). Conclusions The characteristics of blood perfusion are dissimilar for thyroid nodules with different sizes and properties. The quantitative analysis with CEUS can provide valuable information for clinical diagnosis.

Objective To evaluate the clinical value of three-dimensional ultrasonography(3DUS) for breast cancer operation. Methods Sixty-eight patients with breast cancer were examined with two-dimensional ultrasonography(2DUS) and three-dimensional ultrasonography before operation. Results 3DUS not only improved the rate of sonography's diagnosis for breast cancer(88.2 % for two-dimension, 94.1 % for three-dimension), but also clearly showed patterns of breast lumps with the neighboring structure and the adjacent three-dimensional relations and the level of violations, such as the skin, chest muscle, chest wall, etc(the display rate is 75.0 %, 63.6 % and 60.0 % respectively). And it displayed the blood stream distribution in the mass of breast tumor more clearly and sensitively (95.6%). Conclusions 3DUS demonstrated the tumor's configuration, relations and the blood stream distribution. It had great significance in the operation for breast cancer.

Objective To explore the feasibility and efficacy of the selective portal vein embolization (SPVE) before radiofrequency ablation(RFA) for liver tumor large than 3 cm.Methods 63 patients with 63 liver tumor (＞3 cm) located in single liver segment completely or mostly underwent RFA.21 patients (21 lesions) were randomly assigned to receive SPVE before ablation (SPVE + RFA group),other 42 patients were treated with RFA only (RFA group).The complications and treat results of two groups were collected and compared.Results SPVE were achieved in 20 of 21 patients,and no critical complication were happened in both group.During a observation period of median 14.2 months,local tumor progression were observed in 17 of 42 patients (40.5％) in RFA group and in 3 of 20 patients (15.0％) in SPVE+ RFA group,there were significant difference between two groups(P =0.043).Conclusions SPVE can safely and effectively improve the efficacy of RFA for the liver tumors which large than 3 cm and located in single liver segment.

Objective To evaluate interventional therapy for Budd-Chiari syndrome. Methods IVC venography was first carried out, the obliteration or stenosis in the IVC was opened or dilated with the hard tip of guid wire or puncture needle and balloon, then a stent was implanted. Results The procedure was successful in 271 out of 312 cases including IVC intervention in 260 cases, and hepatic vein intervention in 11 cases. IVC stent was used in 195 cases and hepatic vein stent in 1 case. There was no pulmonary embolism happened, acute renal failure occurred in 6 cases, hepatic coma in 1 case and acute heart failure in 21 cases. One patient died in this group and 2 were complicated with acute IVC thrombosis. Follow up of 6 to 104 mos was made in 203 cases with recurrence found in 21 cases. Conclusion Interventional therapy is indicated for most types of BCS with safe and effective results.

Objective To compare the efficacy of transrectal ultrasonography(TRUS)and spiral computed tomography(SCT)in preoperative staging of rectal carcinoma contrasted with the postoperative pathologic findings.Methods Both TRUS and SCT were performed prior to surgery in 92 patients with rectal carcinoma.After radical operation,the preoperative findings were compared with the histological findings,and the the efficacy of TRUS and SCT in staging the rectal carcinoma were evaluated.Results The accuracy of TRUS for T stage and N stage was 87.0% and 64.1% respectively,while the accuracy of SCT was 68.5% and 66.3%.Conclusions TRUS is superior to SCT for the judgment of tumor infiltration depth,TRUS may become the first choice in preoperative staging of rectal carcinoma.But neither is able to provide satisfaction assessment for lymph node metastases.When both methods are used together,it would be better.

Objective To investigate the content of thorium (Th) in surface water in Sichuan Province, China, and to evaluate Th-associated health risk via water intake for residents. Methods Twenty-three monitoring sections were set in main surface water bodies in Sichuan Province. From 2016 to 2021, the Th radioactivity level in the water bodies was measured during dry and normal-water seasons. The health risk of residents was evaluated by calculating radioactive Th intake from the surface water bodies combined with the use of a health risk assessment model. Results The Th radioactivity level of the surface water bodies in Sichuan Province was 0.02-0.67 μ./L. There was no significant difference in the Th radioactivity level of different years or different surface water bodies (P > 0.05). A significant difference was observed in the Th radioactivity level of different water seasons (P < 0.05). The total mean annual committed effective doses of Th in all age groups caused by drinking water and water immersion ranged from 3.14 × 10⁻⁸ to 8.75 × 10⁻⁷ Sv, all lower than the World Health Organization (WHO)-recommended reference level of 0.1 mSv. The overall carcinogenic risks for residents in all age groups ranged from 3.93 × 10⁻¹⁰ to 1.09 × 10⁻⁸, all below the most rigorous control limits issued by WHO and International Commission on Radiological Protection. Conclusion The Th-associated health risk via direct water intake and water immersion in main surface water bodies of Sichuan Province is at an acceptable level. Th in main surface water bodies of Sichuan Province is safe for all age groups.