In recent years, researches on cells, animals, and human beings have found that the carcinogenic mechanism of environmental carcinogen benzo (a) pyrene〔B(a)P〕can reduce methyla?tion of the whole genes, increase the tumor suppressor gene methylation and reduce the gene methyla?tion of proto-oncogene, in addition to the genetic toxicity. It can also cause changes in small RNA expression, the increase of long-chain non-coded RNA expression and imbalance in histone phosphor?ylation expressions. These changes can cause abnormalities in gene expression and chromosome structure and instability, directly leading to cancer. These changes can also cause the corresponding changes of genetic toxicity, such as gene mutation, abnormal genetic damage repair, increas of cell apoptosis and cell cycle arrest. All these are considered to be potential epigenetic mechanisms of B(a)P. Existing researches have provided the scientific basis for the mechanism of and prevention counter?measures for environment-related diseases and vocational diseases caused by B(a)P.

Objective To explore the value of ultrasound in assessment of treatment effect of diffuse toxic goiter.Methods 80 diffuse toxic goiter patients with 131I therapy were selected as research subjects.Before and after treatment,the serum thyroid hormone levels were detected and thyroids were checked by ultrasound.Results Before and after treatment,the FT3 levels were positively correlated with blood flow area ratio and flow grade (r =0.472,0.593,all P ＜ 0.05).After treatment,the thyroid weight,peak systolic velocity(PSV) and end diastolic velocity (EDV) [(12.89 ± 7.86) g,(32.24 ± 21.85) cm/s,(12.36 ± 19.22) cm/s] were significantly lower than those of before treatment [(30.12 ± 17.24) g,(68.58 ± 34.25) cm/s,(28.03 ± 21.24) cm/s] (t =11.265,4.762,3.672,all P ＜ 0.05).Before and after treatment,the RI and PI showed no significant difference(all P ＞ 0.05).The difference of thyroid blood flow grade before and after treatment was statistically significant (x2 =98.959,P =0.000),the proportion of flow grade class Ⅲ before treatment was higher(80.0％),while the proportion of flow grade class Ⅰ after treatment was higher(60.0％).After treatment,the FT3 and FT4 levels [(6.88 ± 4.14)pmol/L,(17.23 ± 7.35)pmol/L]were significantly lower than those of before treatment [(18.79 ± 6.45) pmol/L,(56.47 ± 22.97) pmol/L] (t =17.243,13.254,all P ＜ 0.05).The TSH level [(11.52 ± 8.27) mU/L] was significantly higher than that of before treatment[(0.01 ± 0.00)] mU/L (t =3.365,P ＜ 0.05).After treatment,the thyroid weight,PSV and EDV of cure group[(9.34 ±2.36) g,(20.13 ± 8.59) cm/s,(9.13 ± 5.34cmn/s)] were lower than those of non-cure group [(18.78 ± 8.76) g,(52.32 ± 13.24) cm/s,(17.24 ± 8.34crn/s)] (t =9.143,8.793,5.232,all P ＜ 0.05).The differences of RI and PI in the cure group and non-cure group were not statistically significant (all P ＞ 0.05).Conclusion Ultrasound has a better role in the evaluation effect of 131I therapy for diffuse toxic goiter.

Objective To study the influence of partial internal sphincterotomy on the postoperative pain after cutting seton treatment in patients with perianal infection. Methods A controlled study was carried out on 40 cases of cutting seton insertion with (Group A) or without (Group B) partial internal sphincterotomy. The subjects reported their postoperative pain at defecation and at rest respectively using a visual analogue scale (VAS). The intensity of pain between the two groups was compared. Results All the 40 patients were cured, without recurrence or fecal incontinence. During the period of cutting seton treatment, the pain scores at defecation and at rest were lower in the Group A than in the Group B ( P 0.05). Conclusions Internal sphincterotomy can significantly relieve anal pain after cutting seton treatment, being an effective method.

Objective To understand the microcystin(MC-LR)pollution in drinking water in the city and countryside of Fuling District,Sichuan,China.Methods In 2004,285 water samples were collected from different types of water in Fuling district in different season and the concentration of LR(MC-LR),total phosphorus and total nitrogen in water were determined respectively.Results From July to November in 2004,no LR(MC-LR)was detected and the total phosphorus and total nitrogen did not exceed the national standard limits in the drinking water in the city,but in the secondary water supply in the city,the MC-LR was detected,the total phosphorus and total nitrogen exceed the standard limits.In the countryside,the MC-LR was detected,the total phosphorus and total nitrogen exceed the standard limits.Conclusion In the countryside of Fuling District,Sichuan,China,the drinking water,water source and tap water,was seriously contaminated by microcystin,the total phosphorus and total nitrogen exceed the national standard limits.

Objective To analyze the correlation of acute pancreatitis with hyperlipemia and C reactive pro-tein. Methods 42 patients with acute pancreatitis with hyperlipemia were divided into two groups of SAP group and MAP group under the diagnostic code. The blood fat and CRP were compared between the two groups, also the scores of APACHE Ⅱ , Ranson and CT were measured. Results The CRP and TG in group SAP compared with those in group MAP had significant difference(P<0.01),but the CHOL has no-difference;the scores of APACHEⅡ , Ranson and CT after control lipid in 42 patients were significantly' different( P < 0.05). Conclusion Hyperlipe-mia is one risk factors of the AP;combined with the CRP, it can be one evaluating index of the severity.

Objective　To evaluate the results of radical resection for the treatment of Budd-Chiari syndrome (BCS) caused by short segmental lesions in inferior vena cava (IVC), and major hepatic veins (MHV).　Methods　In this series, resection of IVC occlusive segment and orthotopic artificial vascular graft transplantation were performed in 42 patients. Resection of major hepatic vein, hepatic venous plasty and orthotopic transplantation with artificial vascular graft were performed in 10 patients. Resection of major hepatic vein, anastomosis between hepatic vein and right artrium in 3 cases. Percutaneous transhepatic angioplasty in 10 cases.　Results　One patient died of complication. 58 cases were followed up for an average of 30 months. 3 cases in interventional group suffered recurrence and one in surgical group had recurrence.　Conclusions　The treatment of BCS by resecting inflicted segment of IVC or hepatic veins and orthotopic artificial vascular graft transplantation effect a radical cure in most cases.

Objective [WT5”BZ]To evaluate the results of radical resection for the treatment of Budd Chiari syndrome (BCS) caused by short segmental lesions in inferior vena cava (IVC), and major hepatic veins (MHV).[WT5”HZ]Methods [WT5”BZ]In this series, resection of IVC occlusive segment and orthotopic artificial vascular graft transplantation were performed in 42 patients. Resection of major hepatic vein, hepatic venous plasty and orthotopic transplantation with artificial vascular graft were performed in 10 patients. Resection of major hepatic vein, anastomosis between hepatic vein and right artrium in 3 cases. Percutaneous transhepatic angioplasty in 10 cases.[WT5”HZ]Results [WT5”BZ]One patient died of complication. 58 cases were followed up for an average of 30 months. 3 cases in interventional group suffered recurrence and one in surgical group had recurrence.[WT5”HZ]Conclusions [WT5”BZ]The treatment of BCS by resecting inflicted segment of IVC or hepatic veins and orthotopic artificial vascular graft transplantation effect a radical cure in most cases.

Objective To evaluate the feasibility of combining the sedation performed by propofol targeted concentration in-fusion with epidural anesthesia in patients undergoing total pelvic floor reconstruction.Methods A total of 80 eligible patients were recruited and were assigned randomly into the study group(n=40)and the control group(n=40).All patients in both groups were administered epidural anesthesia with the puncture and catheter placing in the space between the 2nd-3rd lumbar vertebras.After the epidural anesthesia,patients in the study group were administered propofol by targeted concentration infusion (TCI)system. The plasma concentration of propofol was modulated to obtain the BIS maintaining between 65-80,and the OAA/S maintaining at 3 scores.The propofol was continuously infused until closing the incision.Values of HR,MAP at different time points in the opera-tion were recorded,and the plasma concentrations of propofol,the incidences of adverse events were recorded.Results The HR and MAP of patients in the study group decreased at T1 (given the anesthetic),T2 (the beginning of the operation),T3 (the beginning of the operation),compared with those at T0 (before the anesthetic)and T4 (30 min after the operation)(P <0.05).The HR and MAP of patients in the control group elevated at T2 ,T3 ,compared with those at T0 and T4 (P <0.05).The HR of study group at T1 ,T2 , T3 and the MAP at T2 were lower than those in control group.In study group,two asphyxia patients were founded.The incidence of shivering in the study group was lower than that in control group (P =0.014).No statistical difference was found in the incidences of other adverse event between this two groups (P >0.05).BIS of study group was (73.3 ±4.8)-(76.1 ±3.4),and the plasma concentrations of propofol was(1.32 ± 0.29 )μg/mL - (1.52 ± 0.26 )μg/mL.Conclusion The combination of propofol sedation performed by TCI and epidural anesthesia could be safely and effectively used in patients undergoing total pelvic floor reconstruc-tion.

Objective To explore the clinical significance of interventional treatment of iliac vein compression syndrome(IVCS). Methods Percutaneous transluminal angioplasty(PTA) was performed in 40 cases. Thirty three cases underwent endovascular stent implantation and 27 cases underwent second stage left saphenous vein ligation and stripping and the valves of left femoral veins narrowing. Thirty one cases were followed up postoperatively and the duration was 6～66 months (mean 28 months). Results The dilation of iliac veins was successful in 36 cases and there were good efficacy in all patients when they discharged from hospital. Followed up during post operation, all the limbs ulcers were cured and varicose veins disappeared. The skin pigmentation disappeared in 17 of 19 cases and markedly relieved in 2 cases. Left lower limb swelling disappeared in 15 of 17 cases and relieved in 2cases. Conclusion There is good efficacy in the interventional treatment of left iliac vein lesions, but second stage procedures should be performed in secondary lesions of saphenous veins and valves of femoral veins.