1.Ahmed glaucoma valve implantation for those with visual function in neovascular glaucoma
Zeguang XU ; Hongguang WANG ; Qin WANG ; Ruiya ZHOU ; Chaoting WANG
Recent Advances in Ophthalmology 2001;21(3):187-188
Objective To investigate the efficacy and security of the treatment for the with visual function in neovascular glaucoma with Ahmed glaucoma value(AGV ).Methods Twenty-six cases (26 eyes) with visual function in neovascular glaucoma underwent AGV implantation. Results After surgery,the follow-up periods lasted for 4 to 26 months (mean 8 months ),the visual acuity of 22 eyes (86.4%) was improved or remained the same,no case of the blindness was found. The mean intraocular pressure was between 0.8~2.8kPa in 17 eyes,and the Yate of control reaches to 65.4% , the postoperative complication included transicent hyphema, Early hypotony, obstruction of the tube tip and drop out of the plate.Conclusion The AGV implantation treating those with visual function in neovascular glaucoma is an effective and safe method.
2.Clinical study of raltitrexed plus oxaliplatin compared with S1 in treating the patients with advanced primary liver cancer
Deshuai LIN ; Yongqi SHEN ; Chaowen HAN ; Jun HUANG ; Chaoting CHEN ; Tao SI ; Zhixiang WANG ; Huadong XIE ; Xiangying KONG
Journal of International Oncology 2017;44(12):897-901
Objective To evaluate the therapeutic efficacy and adverse reactions of raltitrexed plus oxaliplatin (RALOX project) and S1 in patients with advanced primary liver cancer.Methods Seventy-one patients with advanced primary liver cancer admitted to 6 cancer centers from July 2013 to July 2015 were divided into 2 groups according to the wishes of the patients and their families:RALOX group (34 patients) and S1 group (37 patients).The therapeutic efficacy such as objective remission rate (ORR),disease control rate (DCR),median overall survival (mOS),median progression free survival (mPFS),one year survival rate (SR),and adverse reactions in these patients were evaluated.Results Thirty-one patients could be evaluated in RALOX group,and 6 patients obtained partial response (PR),10 stable disease (SD) and 15 progressive disease (PD).Thirty-three patients could be evaluated in S1 group,and 3 patients obtained PR,8 patients SD and 22 PD.The ORR,DCR,and one year SR were 19.4% vs.9.1%,51.6% vs.33.3%,and 22.6% vs.12.1% respectively,and there were no statistically significant differences in the two groups (x2 =1.393,P =0.238;x2 =2.190,P =0.139;x2 =1.229,P =0.268).The mOS and mPFS were 7.2 months vs.6.1 months and 3.4 months vs.2.8 months,and there were statistically significant differences in the two groups (x2 =6.433,P =0.011;x2 =4.078,P =0.043).There was more serious peripheral nerve toxicity (29.0% vs.3.0%,x2 =6.344,P =0.012) and lighter hand-foot syndrome (9.7% vs.30.3%,x2 =4.201,P =0.040) in RALOX group than S1 group.But the incidences of other adverse effects were similar in the two groups.Condnsion RALOX project is safe and effective to the patients with advanced primary liver cancer.Compare with S1 project,RALOX project has better curative effects and the majority of adverse reactions are tolerable.The patients have good condition control and survival benefit.