Objective To evaluate the clinical effects of interfered therapy of peptic ulcer with lip. Methods 184 patients were randomly divided into two groups,only durgs were given for conventional treatment group:pan- toprazole and teprenone; the same drugs, the type of life and individual diets were given for interfered treatment group. Therapy time lasted for 6 weeks in two groups. Radical eradication of Hp: pantoprazole plus clarithromycinand amoxycilLin. Results The time. of complete alleviation of clinical symptoms: most of patients in interfered treat- ment group alleviated after one week, half past patients in conventional treatment group alleviated after one week; there were significant difference in alleviation rate of clinical symptoms between two groups( P < 0.01 ). Healing of ulcer:after the end of treatment, all patients underwent endoscopy, most of ulcers healed in interfered treatment group, but 90.22% of ulcers healed in conventional treatment group, there were significant difference in he.sling rate of ulcer between two groups(P< 0.05). Eradicating of Hp: the eradicating of Hp was similar in two groups,there were no significant difference between the interfered treatment group and the conventional treatment group (P > 0.05). Conclusion Through the interfered treatment(drugs combining the type of life and the habit of diet), we can alleviate clinical symptoms and improve the effects of healing of ulcer.