Objective To observe the changes of serum C reactive protein (CRP) and blood glucose in patients with non small cell lung cancer after video-assisted thoracoscopic surgery.Methods 96 patients with non small cell lung cancer were selected,and they were randomly divided into the observation group (48 cases) and the control group(48 cases) according to the digital table.The observation group received thoracoscopic surgery,while the control group received traditional thoracotomy.The changes of serum CRP and fasting blood glucose were compared between the two groups before and after operation,at 24h,36h and 72h after operation.Results The operation time of the observation group [(198.3 ± 36.4) min] was longer than that of the control group [(136.5 ± 30.8) min] (t =3.014,P ＜0.05).There was no significant difference in the number of lymph node dissection between the two groups [(13.4 ± 2.8) vs.(14.1 ± 2.6)] (t =1.082,P ＞ 0.05).The amount of intraoperative bleeding,drainage time,postoperative drainage volume,postoperative pain score in the observation group were (149.2 ± 44.7)mL,(6.1 ± 2.5) d,(781.6 ± 59.6) mL,(5.2 ± 1.6) points respectively,which in the control group were (261.5 ± 57.2) mL,(8.6 ± 2.9) d,(1103.6 ± 87.3) mL,(8.5 ± 2.0) points respectively,the differences were statistically significant between the two groups (t =7.152,2.741,6.034,2.925,all P ＜ 0.05).The incidence rate of postoperative complications in the observation group was 4.2％,which was significantly lower than 10.4％ in the control group (x2 =8.960,P ＜ 0.05).There was no significant difference in serum CRP between the two groups (t =0.5612,P ＞ 0.05).The postoperative serum CRP was significantly increased,and CRP levels of postoperative 24h,36h,72h in the observation group [(81.26 ± 10.24) mg/L,(49.64 ± 9.17) mg/L,(27.53 ± 5.38) mg/L] were lower than those of the control group [(98.46 ± 11.28) mg/L,(60.73 ± 9.82) mg/L,(39.78 ± 6.14) mg/L] (t =4.921,4.068,3.724,all P ＜ 0.05).There was no statistically significant difference in preoperative blood glucose between the two groups(t =0.3942,P ＞ 0.05).The postoperative blood glucose was significantly increased,and blood glucose levels of postoperative 24h,36h,72h in the observation group[(9.75 ± 1.91) mmol/L,(7.64 ± 1.06) mmol/L,(6.39 ± 0.72) mmo]/L] were lower than those of the control group [(13.25 ± 2.06) mmol/L [(9.77 ± 1.53) mmol/L [(8.03 ± 0.69) mmol/L](t =8.912,4.601,3.005,all P ＜ 0.05).Conclusion Thoracoscopic surgery for non-small cell lung cancer has less impact on CRP and blood glucose,it may be more favorable for patients prognosis.

This paper comprehensively discusses on the potential neurobiological mechanisms of acupuncture in the treatment of tobacco dependence， focusing on three important aspects， including acupuncture's regulation of tobacco dependence behavior， effects of acupuncture on withdrawal syndrome， and the role of acupuncture in preventing relapse. It is found that acupuncture can inhibit drug-seeking behavior by regulating the reward pathway and related neurons， such as dopamine， thus modulating tobacco dependence behavior. It also alleviates withdrawal symptoms by improving the oral environment of smokers and reducing negative emotions after quitting. Furthermore， acupuncture can prevent relapse by decreasing brain network activity related to smoking cravings and improving cognitive brain functions like addiction memory. Currently， research on the specific neurobiological mechanism of acupuncture in treating tobacco dependence and the involved neural circuits is limited. Future research directions are proposed， including the evaluation of clinical effects， exploration of specific therapeutic mechanisms， investigation of brain pathology， and strengthening the exploration of brain functions. Additionally， combining modern technologies to clarify the neural circuits involved in acupuncture intervention will provide a basis for acupuncture treatment of tobacco addiction.