1.Correlation research of hope level and illness perception among patients with coronary heart disease after per-cutaneous coronary intervention
Chinese Journal of Practical Nursing 2014;30(25):64-66
Objective The aim of this study was to examine hope level in patients with coronary heart disease after per-cutaneous coronary intervention and explore correlation with illness perception.Methods 176 patients in outpatient department were recruited after per-cutaneous coronary intervention.The Herth Hope Index (HHI),Illness perception Questionnaire-Revised and demographic and clinical characteristics were collected.Results The hope level score of patients after per-cutaneous coronary intervention was (36.18±3.21),the hope level was correlated with seven dimensions of illness perception and was influenced by degree of education,income level,whether the disease is acute or chronic and control belief.Conclusions The patients after per-cutaneous coronary intervention show high level of hope and is affected by many factors,this provides the basis for taking effective measures to improve the patients' level of hope.
2. Chemical constitutes from flesh of Trichosanthes kirilowii
Chinese Traditional and Herbal Drugs 2019;50(14):3284-3290
Objective: To investigate the chemical constituents from the flesh of Trichosanthes kirilowii. Methods: The chemical constituents from n-butanol fraction of 95% ethanol extract of the flesh of T. kirilowii were separated by silica gel and ODS chromatogram columns as well as preparative HPLC. On the basis of NMR and MS data analysis, their structures were elucidated. Results: Twenty-six compounds were isolated from 95% ethanol extract of T. kirilowii, of which six organic esters were ethyl laurate (1), dibutyl phthalate (2), diethyl ethaneioate (3), dibutyl-2-malate (4), 6,10,14,18-tetramethyl-2-ethyl-7-ene-3-hydroxyl-ninecanol- 1-butyl ester (5), drechslerol-B (6), nine organic acids and phenolic acids were p-hydroxybenzaldehyde (7), salicylic acid (8), vanillic acid (9), isovanillic acid (10), protocatechuate (11), trans-cinnamic acid (12), p-hydroxycinnamic acid (13), trans-ferulic acid (14), and lauric acid (15), eight flavonoids were diosmetin (16), apigenin (17), chrysoeriol (18), luteolin (19), 4’-hydroxyscutellarin (20), quercetin (21), diosmetin-7-O-β-D-glucoside (22), chrysoeriol-7-O-β-D-glucoside (23), two aldehydes were 5-acetoxymethyl- 2-furaldehyde (24), 5-hydroxymethyl furfural (25) and one cycloaltinol compounds was cyclotucanol 3-palmitate (26). Conclusion: All compounds except compound 10 are isolated from the Trichosanthes genus for the first time.
3.The protective effects of erythropoietin/erythropoietin receptor system on optic nerve and retinal diseases
Zheng-gao, XIE ; Chao-rong, ZHUANG
Chinese Journal of Experimental Ophthalmology 2011;29(8):765-768
Erythropoietin(EPO) has an anti-apoptotic effect,and promotes the proliferation and differentiation of erythroid progenitor cells. Several studies have indicated that EPO can protect photoreceptor cells from the lightinduced retinal degeneration ;protect retinal neurons from ischemia-reperfusion injury and retinal ganglion cells after acute and chronic ocular hypertension; promote ganglion cell survival and axonal regeneration after optic nerve transaction; attenuate inflammation in multiple sclerosis optic neuritis; reduce the permeability of the retinal barrier and protect retinal neurons in diabetic retinopathy; enhance the stability of hypoxic retinal vessels in retinopathy of prematurity. Herein,we review the distribution of EPO and its receptor in retina,their expression in animal model of retinal diseases,and their effects and mechanisms in protection of retinal neurons and optic nerve.
4.Phosphatase of regenerating liver-3 (PRL-3) and tumor metastasis.
Li-rong PENG ; Cheng-chao SHOU
Chinese Journal of Oncology 2007;29(1):1-3
Animals
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Colonic Neoplasms
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metabolism
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pathology
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Female
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Humans
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Liver Neoplasms
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metabolism
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secondary
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Lymphatic Metastasis
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Neoplasm Proteins
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metabolism
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Ovarian Neoplasms
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metabolism
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pathology
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Protein Tyrosine Phosphatases
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metabolism
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Stomach Neoplasms
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metabolism
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pathology
6.Optimum Training System for Clinical Rehabilitation Professionals
Shenqiao YANG ; Rongjiang JIN ; Rong LUO ; Xin YANG ; Chao DONG
Chinese Journal of Rehabilitation Theory and Practice 2012;18(2):188-189
The training system of rehabilitation talents and its problems were reviewed. The paper discussed a training system as to how to enhance students' clinical operating skills and innovation abilities to ensure the teaching quality and level in order to promote students'employment competitive, mainly from the aspects of teaching system, group of teachers and training base of training rehabilitation talents' clinical operating ability.
7.A case report of epiglottic angiomyolipoma. .
Li-hua ZHANG ; Rong-chao SUN ; Ying CHEN
Chinese Journal of Pathology 2005;34(10):645-645
Actins
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metabolism
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Angiomyolipoma
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metabolism
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pathology
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surgery
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Epiglottis
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Factor VIII
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metabolism
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Humans
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Laryngeal Neoplasms
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metabolism
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pathology
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surgery
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Male
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Middle Aged
8.The antidiabetic and hepatoprotective effects of magnolol on diabetic rats induced by high-fat diet and streptozotocin.
Jun-Jun WANG ; Rong ZHAO ; Ji-Chao LIANG ; Yong CHEN
Acta Pharmaceutica Sinica 2014;49(4):476-481
The effects of magnolol (Mag) on hyperglycemia and hyperlipemia, hepatic oxidative stress and cytochrome P4502E1 (CYP2E1) activity of diabetic rats induced by high-fat diet (HFD) and streptozotocin (STZ) were studied. After oral administration of Mag (25, 50 and 100 mg x kg(-1) x d(-1)) for continuous 10 weeks, the blood glucose and lipids (TC, TG and LDL-C) levels, as well as the hepatic CYP2E1 activity and MDA content of diabetic rats, decreased significantly (P < 0.05 or P < 0.01), whereas the oral glucose tolerance and hepatic antioxidant enzymatic activities (CAT and GSH-Px) of diabetic rats, increased significantly (P < 0.05 or P < 0.01). The results indicated that Mag was effective against the hepatic oxidative damage, hyperglycemia and hyperlipemia of diabetic rats induced by HFD and STZ, and the inhibition of Mag on hepatic CYP2E1 activity could be an important mechanism of Mag against hepatic insulin resistance and oxidative damage.
Animals
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Biphenyl Compounds
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isolation & purification
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pharmacology
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Blood Glucose
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metabolism
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Cholesterol
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blood
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Cholesterol, LDL
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blood
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Cytochrome P-450 CYP2E1
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metabolism
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Diabetes Mellitus, Experimental
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blood
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drug therapy
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metabolism
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Diet, High-Fat
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Glucose Tolerance Test
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Hypoglycemic Agents
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isolation & purification
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pharmacology
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Lignans
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isolation & purification
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pharmacology
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Liver
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metabolism
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Magnolia
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chemistry
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Male
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Oxidative Stress
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drug effects
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Plants, Medicinal
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chemistry
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Protective Agents
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pharmacology
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Rats
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Rats, Wistar
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Streptozocin
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Triglycerides
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blood
9.Relation between cervical squamous cancer lesion among Uighur and Han ethnic women in Xinjiang with expression of PI3K,ERK,IGF-1R and ER protein
Jing DU ; Xiaoling RONG ; Chao NING ; Jing SHA
Chongqing Medicine 2016;45(18):2484-2487
Objective To observe the expression levels of PI3K ,ERK ,IGF‐1R and ER in cervicitis and cervical squamous cancer tissues among Uighur and Han ethnic patients and their correlation .Methods The 90 paraffin embedding samples of cervici‐tis tissue( 46 cases for Han and 44 cases for Uighur) and 224 paraffin embedding samples of cervical squamous cancer tissue (36 ca‐ses for Han and 188 cases for Uighur) were collected and detected the protein expression levels by using immunohistochemistry .Re‐sults The positive expression rates of IGF‐1R and PI3K in cervical squamous cancer were 58 .04% and 92 .41% respectively ,which were higher than 13 .33% and 57 .78% in cervicitis tissue ,the positive expression rates of ER and ERK in cervical squamous cancer were 22 .32% and 68 .30% respectively ,which were lower than 63 .33% and 95 .56% in cervicitis tissue ;the positive expression rate of IGF‐1R and PI3K of cervical squamous cancer in Han and Uighur were 69 .44% ,88 .89% and 55 .85% ,93 .09% respective‐ly ,which were higher than 15 .22% ,54 .35% and 11 .36% ,61 .36% of cervicitis tissue ;the positive expression rate of ER and ERK of cervical squamous cancer in Han and Uighur were 13 .89% ,83 .33% and 23 .94% ,65 .43% respectively ,which were lower than 65 .22% ,93 .48% and 61 .36% ,97 .73% of cervicitis tissue respectively ;the expression of ERK in Uighur cervical squamous carci‐noma tissue was 65 .43% ,which was lower than 83 .33% in Han ,the difference was statistically significant (P<0 .01) .Conclusion PI3K ,ERK ,IGF‐1R and ER protein expression positive or deficiency is closely related to the occurrence of cervical cancer ,which may serve as the important biological indicators for detecting cervical cancer ,and the ethnic difference of ERK protein expression exists in cervical cancer .
10.Bone ultrasound backscatter in the detection of bone nutritional status in term infants
Jialin GUO ; Rong ZHANG ; Mingzhu YAO ; Jiangqin LIU ; Chao CHEN
Chinese Journal of Perinatal Medicine 2016;19(6):450-455
Objective To establish a reference range of cancellous bone ultrasonic backscatter coefficient (BSC) in term neonates,and to determine the significance of BSC in bone nutritional status in term newborns and infants.Methods Six hundred and sixty-five term newborns,who were born in Shanghai First Maternity and Infant Hospital from July 2014 to August 2014,were enrolled.On the third day and the 42nd day after birth,all infants underwent ultrasonic measurement of the calcaneum bone using a broadband-non-focus ultrasonic transducer at three frequencies (2.25,3.5 and 5 MHz).MATLAB software was used to analyze the backscatter signals.Clinical data of the infants,including gestational age,birth weight and birth age,were recorded at the same time.Statistical analyses of the data included variance analysis,Tukey's test,rank sum test,Dunn test and Pearson or Spearman correlation analysis.Results (1) Of the 665 infants,335 were male.The mean gestational age at birth was (38.0± 1.9) weeks,and the mean birth weight was (3 1524±226) g.(2) On the third day,there were significant differences in BSC values acquired at 2.25 and 3.5 MHz among the groups with different gestational ages or birth weights (2.25 MHz:H=9.842 and 17.271;3.5 MHz:H=6.275 and 21.450,respectively,all P<0.05).At 3.5 and 2.25 MHz,BSC values were positively correlated with gestational age (r=0.047 and 0.035,respectively,both P<0.05) and birth weight (r=0.125 and 0.186,both P<0.05).(3) On the 42nd day,significant differences in BSC were observed at each frequency among the groups with different gestational ages or birth weights (gestational age:H=76.832,16.498 and 32.756;birth weight:H=70.014,18.095 and 34.126;all P<0.01).Gestational age and birth weight were positively correlated with BSC value acquired at each frequency (r=0.397,0.286 and 0.272 for gestational age,0.451,0.223 and 0.196 for birth weight;all P<0.01).Conclusions A preliminary BSC reference percentile in term-born infants is established.There are positive correlations between BSC value and newborn gestational age and birth weight at certain frequencies,which can reflect the status of the newborn's cancellous bone.Determination of BSC value should be performed during the follow-up period to assess the nutritional status of neonatal bone.