Objective To describe the methods of treatment of fresh and old fractures of the elbow joint with internal fixation.Methods Ten cases of fracture of the elbow with complete records were reviewed; 9 of them were male and 1 female; 6 of them were Han people and 4 Tibetans. The average age was 31 years. Four cases had open fractures and 6 had closed fractures. Among the cases of open fractures, 3 were treated with routine debridement and internal fixation of the fragments or internal fixation plus advanced skin flaps. One was treated as closed fractures after wound healing. The 6 cases of closed fractures were treated with a single tension band wiring, tension band and screw fixation, or screw fixation. Results The mean duration of the follow up was 8 months. Fracture healing was seen at 3－ 4 months. The range of motion of fresh fractures of the elbow and forearm was  4.2° － 144.2° . The old fracture cases had the range of motion of  31.3° － 115° without restriction in pronation and supination. Conclusion The intra articular fracture of elbow joint must be treated with early surgery to attain anatomical reduction with firm internal fixation. Early functional exercise is also important for the recovery.

There are many kinds of the scaffolds of tissue engineered cartilage, including collagen, polylactic acid hybrid material, chitosan and decellular extracellular matrix. They all have biocompatibility, safety and stable physicochemical property, which indicate good application value in the field of tissue engineering. Moreover, the composite scaffolds are superior to simple scaffold. It is potential scaffold materials that developing into composite materials, biomimetic materials, modified natural materials, intelligent material and nano-technological materials.

Female ; Humans ; Adenomyosis/surgery* ; Endometriosis/diagnosis* ; Early Diagnosis ; Attention

BACKGROUND: The intraoperative blood loss of unicompartmental knee arthroplasty is lower than that of total knee arthroplasty, but the difference of postoperative occult blood loss between them has not been widely studied. OBJECTIVE: To compare the difference of occult blood loss between unicompartmental knee arthroplasty and total knee arthroplasty, and to analyze whether patients with preoperative anemia can also undergo unicompartmental knee arthroplasty without the risk of blood transfusion. METHODS: 148 patients with knee osteoarthritis treated in 904 Hospital of the Joint Service Support Force of Chinese PLA from January 2014 to December 2016 were selected. Among them, 58 cases underwent unicompartmental knee arthroplasty and 90 cases underwent total knee arthroplasty. Hemoglobin levels and hematocrit were measured before and 1, 4, 21 and 42 days after operation, and the occult blood loss and blood transfusion rate were calculated. The trial was approved by the Ethics Committee of 904 Hospital of the Joint Service Support Force of Chinese PLA (approval No. 2019-01-03). RESULTS AND CONCLUSION: (1) The hemoglobin level of unicompartmental knee arthroplasty group was higher than that of total knee arthroplasty group at 1 and 4 days after operation (P < 0.01). There was no significant difference in hemoglobin level between the two groups before operation and 21, 42 days after operation (P > 0.05). (2) Hematocrit in the unicompartmental knee arthroplasty group was higher than that in the total knee arthroplasty group at 1 and 4 days after operation (P < 0.01). There was no significant difference in hematocrit between the two groups before operation and 21, 42 days after operation (P > 0.05).(3) From day one to day four after surgery, there was no occult blood loss in the female of unicompartmental knee arthroplasty group, and the average occult blood loss in the male was 4 g/L. The average occult blood loss was 10 g/L in female and 7 g/L in male in total knee arthroplasty group. The occult blood loss in male and female in unicompartmental knee arthroplasty group was lower than that in total knee arthroplasty group (P < 0.05 or P < 0.01). (4) The blood transfusion rate was 0% in unicompartmental knee arthroplasty group and 4.4% in total knee arthroplasty group. In patients with preoperative moderate anemia (hemoglobin 60-89 g/L), there was no need for blood transfusion in unicompartmental knee arthroplasty group (n=3), but blood transfusion was needed in 2 of 6 patients in total knee arthroplasty group (33%). (5) The results showed that unicompartmental knee arthroplasty had obvious advantages over total knee arthroplasty in postoperative occult blood loss.

Cardiomyopathy, Dilated ; complications ; drug therapy ; Female ; Humans ; Mesenteric Artery, Superior ; drug effects ; physiopathology ; Mesenteric Vascular Occlusion ; complications ; drug therapy ; Middle Aged ; Thrombolytic Therapy ; Treatment Outcome

BACKGROUND:Traditional total knee arthroplasty adopts medial parapatel ar approach, which induces severe trauma, requires long-term rehabilitation, and interferes the end point of quadriceps femoral tendon on superior patel ar pole. Total knee arthroplasty by subvastus approach has no impact on the knee-extension equipment, but it cannot provide sufficient exposure of surgical field and can induce damage to femoral muscle, so its application and safety need further exploration.
OBJECTIVE:To explore clinical effect of total knee arthroplasty by subvastus approach and medial parapatel ar approach.
METHODS:A total of 78 patients with 82 knees who were candidates for total knee arthroplasty were randomly divided into two groups. Treatment group (39 cases;41 knees) was given subvastus approach and control group (39 cases;41 knees) was given median parapatel ar approach. The knee function, range-of-motion of knee joint and complications after total knee arthroplasty were observed and compared.
RESULTS AND CONCLUSION:Compared with control group, the operation time in treatment group was significantly increased, while the postoperative wound drainage, straight leg raising time and walking time were obviously reduced (P<0.05). The scores of HSS before surgery and 12 weeks after surgery were not significantly different between the two groups (P>0.05), while at 1 and 6 weeks after surgery the scores in treatment group were significantly higher than those in control group (P<0.05). The range-of-motion of knee joint and MMT rank for quadriceps muscle were significantly improved in two groups after treatment (P<0.05), and those indicators in treatment group were more significant than the control group (P<0.05). The incidences of complications in treatment group and control group were 2.6%and 15.4%, respectively, with statistical y significant difference (P<0.05). The total knee arthroplasty by subvastus approach has less impact on the extensor mechanism, improves the recovery of knee function and range-of-motion of knee joint, and reduces the incidence of complications.

AIM: To observe the antifungal action of Huanglian Pikang tincture (HPT). METHODS: An anifungal experiment was performed in vitro. RESULTS: HPT had obvious antibacterial actions for the trichophyton rubrum, T. interdigital, epidermophyton floccosum, candida albicans and lessened the colonies (n=5, P

Objective To investigate the role of c-Jun N-terminal kinase (JNK1/2) signaling pathway in enterovims 71 (EV71) infection.Methods The effects of different concentrations of SP600125 on the activity of human rhabdosarcoma (RD) cells were detected by trypanbalu staining.The levels of VP1 mRNA and protein in EV71-infected RD cells were detected by real time Q-PCR and western blot,respectively.The levels of total and phosphorylated JNK1/2,c-Fos and c-Jun protein were determined by western blot.Last,the effects of.JNK1/2 inhibitor SP600125 on EV71 replication and JNK1/2 signaling pathway were analyzed.Results The results of trypanbalu staining showed that 5 and 10 μmol/L of SP600125 didn't influence on the activity of RD cells (P ＞ 0.05),while 20 μmol/L of SP600125 decreased the survival of RD cells significantly (P ＜ 0.05).Compared with the control,the expression levels of VP1 mRNA and protein in EV71-infected RD cells decreased obviously at 8 hours post-infection (P ＜0.01).In addition,after RD cells were infected EV71,the levels of phosphorylated JNK1/2,c-Fos and c-Jun increased significantly (P ＜ 0.05).However,the pretreatment of SP600125 decreased the phosphorylation levels of JNK1/2,c-Fos and c-Jun protein obviously (P ＜ 0.05).Conclusion EV71 infection may effectively activate the JNK1/2 signaling pathway in RD cells,which may be related to EV71 replication.

BACKGROUND: Cartilage stent materials were abundant. With the development of preparation technique, structure, and surface modification technique, performance of materials were improved remarkably; thus, Integrated-repaidng defects of articular cartilage and subchondral bone required high stability of cartilage replacement materials.OBJECTIVE: To evaluate the effect of polyurethane/nano-hydroxyapatite+polyamide66 (PU/n-HA+PA66) biological composite material on repairing articular cartilage and subchondral bone.METHODS: Twenty dog models were randomly divided into 4 groups: porous PU/n-HA+PA66 implant group, compact PU/n-HA+PA66 implant group, n-HA+PA66 implant group and blank control group. The macroscopic and histological evaluations were performed at 4, 12, and 24 weeks postoperatively. The interfaces of biomaterial implants with articular cartilage were observed by scanning electron microscope.RESULTS AND CONCLUSION: After 12 and 24 weeks, bone tissue grew into lower layer materials. Porous PU was well fused with peripheral cartilage. At 24 weeks postoperatively, the porous PU was closely connected with surrounding articular cartilage than the compact PU, and the articular cartilage surrounding the compact PU degenerated obviously. PU/n-HA+PA66 had a similar structure with normal cartilage and subchondral bone and had remarkable effects on repairing defects of articular cartilage and subchondral bone.

BACKGROUND: Polyvinyl alcohol hydrogel (PVA) has been generally considered as a good substitute material of articular cartilage. Polyamide 66 (PA66) polymer has achieved an extensive application in the fields of engineering and medicine owing to its high intensity, strong tenacity and good stability. Polyurethanes exhibit good histocompatibility and blood compatibility and show distinct advantages in repairing cartilage.OBJECTIVE: To compare the outcomes of repairing articular cartilage defects in rabbit knee joints with three materials and to find the best material.METHODS: Thirty-six healthy adult New Zealand rabbits were prepared for the models of articular cartilage defects by perforating on the patellofemoral joint and randomly divided into 4 groups, with 9 animals in each group. PVA, polyurethane, and PA66 were implanted into the into articular cartilage defects in rabbits of corresponding groups. There was no treatment in the control group.The macroscopic and histological evaluations of rabbit knee joints were performed at 4, 8 and 12 weeks postoperatively. The score of histology was used to evaluate the repairs of articular cartilage defects at 12 weeks postoperatively.RESULTS AND CONCLUSION: No infection was observed in all animals with good motion of joints. At 12 weeks postoperatively, the materials got well with surrounding cartilage, which did not degenerate obviously. The defects in the control group were filled with fibrous scar-like tissues that arranged in disorder. The histological score of the in the group implanted by PVA, as well as polyurethane, was higher than that in PA66 and the control groups (P < 0.05), but the difference between the two groups had no significance (P>0.05).The porous materials PVA and polyurathane have good function for replacing articular cartilage, with good biocompatibility.