OBJECTIVE To analyze the curative effect and bacterial clearance of meropenemagaint infections.METHODS To analyze 2732 cases with infection from more than 170 hospitals after meropenem.RESULTS The effectiveness ratio on various infections of blood,lungs treatmeot liver,gallbladder,and pancreas systems and on infections after transplantabions was 80.3%,87.1%,63.6% and 73.3%,respectively;the total clinical effectiveness ratio was 83.5%.The bacterial clearance ratio in various infections of blood,lungs liver,gallbladder,and pancreas systems and in infections after transplantations was 33.5%,66.2%,65.5% and 66.7%,respectively;the total bacterial clearance ratio was 52.7%.CONCLUSIONS Meropenem is effective against infection in clinical patients.The total clinical effectiveness ratio is 83.5%.The total bacterial clearance ratio is 52.7%.

To investigate the changes of inducible nitric oxide synthase mRNA (iNOSmRNA) in pulmonary tissues of tail suspended rats during simulated weightlessness, experiments on 40 Spragno Dawley male rats were conducted. The rats were divided into 4 groups:suspended for 7d, and its control, suspended for 21d, and its control tail suspension(-30 ) was used as weightlessness simulation.The condition of iNOSmRNA in pulmonary tissues was examined by hybridization in situ.The results showed that the level of iNOSmRNA in pulmonary tissues of 7d tail suspended rats increased significantly( P

To investigate the changes of vascular endothelial growth factor mRNA (VEGFmRNA) in pulmonary tissues of tail suspended rats during simulated weightlessness,the experiments were conducted on 40 Spragno Dawley male rats,divided into 4 groups:suspended for 7d,control of 7d and suspended for 21d,control of 21d.Tail suspension(-30?) was used as weightlessness simulation.The condition of VEGFmRNA in pulmonary tissues was examined by hybridization in situ. The results showed that the level of VEGFmRNA in pulmonary tissues of 7d tail suspended rats increased significantly( P

To investigate the changes of cell apoptosis genes in pulmonary tissue of tail suspended rats during simulated weightlessness, 40 Spragno Dawley male rats were divided into 4 groups: suspended for 7d,control of 7d, suspended for 21d, and control of 21d.Tail suspension(-30?) was used as weightlessness simulation.The condition of bcl 2/bax in pulmonary tissues was detected by in situ hybridization. The results showed that the level of bcl 2 mRNA in pulmonary tissue of 7d tail suspended rats decreased significantly( P 0 05). The results also showed that the level of bax mRNA in pulmonary tissue of 7d tail suspended rats increased significantly( P 0 05).It can be concluded that there are certain changes of cell apoptosis genes in pulmonary tissue of 7d tail suspended rats during simulated weightlessness.

Objective To investigate the expressions and clinical significance of survivin, and lymphatic vessel endothelial hyaluronan receptor 1 ( LYVE-1) in gastric cancers.Methods The expres-sions of survivin and LYVE-1 were detected with streptavidin avidin-peroxidase ( SP) immunohistochemical method in 70 cases of gastric cancers and 50 cases of normal gastric tissues.The relationship between the expressions of survivin and LYVE-1 with the clinicopathological parameters was analyzed.Results The ex-pression rate of survivin was 65.71%(46/70) in gastric cancers, and 6.00% (3/50) in normal gastric tissues, with statistically significant difference between two groups (χ2 =43.048, P <0.01) .The expres-sion of survivin was different in gastric cancers:survivin expression rate was 76.92%in poorly differentia-ted gastric carcinomas, 75.00%in T3 ~T4 gastric carcinomas, 75.61%in the positive lymph node metas-tasis of gastric cancers, and 77.08%in the Ⅲ~Ⅳ gastric cancer tissues; which was significantly higher than the highly differentiated (51.61%), T1 ~T2(38.89%), lymph node-negative (51.72%), andⅠ~Ⅱperiod (40.91%) ( P <0.05).The expression of survivin in gastric cancers was no obvious correlation with the age, gender and tumor site ( P >0.05).The expression rate of LYVE-1 was 32.86%(23/70) in gastric cancers, and 4.00%(2/50) in gastric ulcers, with significant difference between two groups (χ2 =14.726, P <0.01) .The expression of LYVE-1 was different in gastric cancers:LYVE-1 expression rate was 40.38%in T3 ~T4 gastric carcinomas, 46.34%in the positive lymph node metastasis of gastric canc-ers, 41.67% in the Ⅲ ~Ⅳ gastric cancer tissues; which was significantly higher than the T1 ~T2 (11.11%), lymph node-negative (13.79%), andⅠ~Ⅱperiod (13.64%) ( P <0.05).The expres-sion of LYVE-1 in gastric cancers was no obvious correlation with the age, gender, tumor site, and the de-gree of differentiation ( P >0.05 ) .There was a positive correlation between expressions of survivin and LYVE-1 in gastric cancers ( r =0.271, P <0.05).Conclusions Survivin and LYVE-1 were abnormally expressed in gastric cancers with a colose relationships between two parameters.They might play important roles in tumorigenesis and progression of a gastric cancer.

Ojective To study the endothelial mechanism of simulated weightlessness on the reactivity of pulmonary artery. Methods Experiments were conducted using 32 Wistar male rats, which were randomly divided into 2 groups: tail-suspended group and control group, 16 rats for each group. Tail-suspension for 14 days was used to simulate the effects of microgravity. The changes in responses of pulmonary artery to several vascular active agents were determined by using in vitro vessel rings perfusion technique. And the changes were determined again after the endothelium of pulmonary artery was removed. Results Compared with the control group, the contractile responses of pulmonary artery to potassium chloride (68mmol/L) and phenylephrine (PE, 10 -7 ~10 -5 mmol/L) were markedly diminished after 14 days tail-suspension, while the dilatory responses to acetylcholine (Ach, 10 -8 ~10 -6 mmol/L) were markedly enhanced. The vascular reactivity of endothelium-removed pulmonary artery rings to PE and sodium nitroprusside (SNP) did not change after 14 days tail-suspension. Conclusion The contractile responsiveness is attenuated and the dilatory responsiveness is enhanced in the rats' pulmonary arteries after simulated weightlessness. That the pulmonary artery endothelium changes in structure or function after simulated weightlessness might be an important cause of changing in the reactivity of pulmonary artery.

10 years. Pulmonary functions were determined routinely and followed for 10 years. Results Comparison between the values of pulmonary functions at the beginning and end of a 10- year follow-up showed very significant difference in the groups of Ⅲ, Ⅳ and Ⅴ. Among the parameters examined, FEV_1, PEF, MMEF, and MVV showed significant increase in these 3 groups (P

Objective To investigate the effects of dexamethasone on prevention of apoptosis in pulmonary tissues of rats after simulated weightlessness. Methods Tail suspension was used to simulate weightlessness. Thirty Sprague-Dawley male rats were divided randomly into 3 groups: control group, tail suspension for 7 days group, and dexamethasone treatment after suspension group. TUNEL technique was used to detect cell apoptosis in pulmonary tissues. Results The rate of apoptotic cells in the lung of rats suspended for 7 day was higher than that of control group(P

Objective To investigate the effects of dexamethasone on inducible nitric oxide synthase (iNOS) in pulmonary tissues of tail-suspended rats simulating weightlessness. Methods Twenty Sprague-Dawley male rats were randomly divided into 2 groups: tail-suspended for 7 days (n=10) without treatment and dexamethasone treatment group (n=10). Tail-suspension was used to simulate weightlessness. The expression of iNOS in the pulmonary tissue was examined by Western blot and immunohistochemistry. Results The results showed that the level of iNOS in the pulmonary tissue of treatment group was decreased significantly(P

To study changes of lung function for 10 years in the elder patients with chronic obstructive pulmonary diseases (COPD) who have quitted smoking for more than 10 years, 45 elder patients with COPD who had quitted smoking for more than 10 years were selected, and 11 elder patients with COPD who had never smoked were enrolled too. Routine lung function tests were performed. Initial values of VC, FVC, FEV 1 , PEF, MMEF, and MVV were compared with those 10 years later, and it was found the difference was significant ( P