Objective:To investigate heart rate variability(HRV)and its circadian rhythm of patients with isolated systolic hypertension.Methods:HRV was evaluated by using 24-hour Holter monitoring in 92 isolated systolic hypertensive patients, and compared with age-matched normal controls.Furthermore,HRV and its circadian rhythm were evaluated in two subgroups with and without left ventricular hypertrophy(LVH).Results:All HRV time domain index were lower among patients than normal controls.As compared with the patients with and without LVH,rMSSD and pNN50 were significantly decreased in patients with LVH.The circadian rhythm was blunted in patients without LVH,but it was absent in patients with LVH.Conclusion:Our results suggest that HRV is decreased in isolated systolic hypertensive patients.Parasympathetic tone is lower in patients with LVH than those without LVH,and the sympathetic/parasympathetic tone is altered.

Objective:To investigate the correlation between the change of blood glucose and liver function after oral glucose tolerance test in cirrhotic patients.Methods:36 cirrhotic patients were classified into A,B and C groups according to Child-Pugh score.36 cirrhotic patients and 12 normal controls were given oral glucose tolerance test(OGTT)of 75g glucose after over night fasting.Venous blood samples OGTT 0,30,60,120 and 180 minutes were obtained.Results: The OGTT 60 and 120 minute's blood glucose values in total cirrhotic group were significantly higher than that in the controls(P

Objective:We study on the relationship among the concentration of serum uric acid,the concentration of serum C-reactive protein and the severity of coronary lesions.Methods:176 patients were divided into two groups(groupⅠ:coronary artery lesions group and groupⅡ:non-coronary artery lesions group) by coronary angiography,the concentration of serum uric acid and serum C-reactive protein were measured in each patients.the relationship among the severity of coronary lesions and the concetration of serum uric acid,the concetration of serum C-reactive protein were analysed by liner-correlated analysis.Results:the concentration of serum uric acid and serum C-reactive protein were increased in the groupⅠ,the concetration of serum uric acid and serum C-reactive protein correlated with Gensini scores.Conclusion:The results suggest that the increased serum uric acid and C-reactive protein play important role in the formation and development of coronary artery disease.

Objective:To investigate the long effect of pereutaneous coronary intervention(PCl)on heart rate variability(HRV) in patients with coronary artery disease(CAD),and to evaluate the prognosis of patients with CAD receiving PCI.Methods:To choose 32 patients confirmed by coronary arteriography and suitable for PCl,and to choose 32 control patients with non-CAD confirmed by coronary arteriography,HRV indices were analyzed hefore PCI and Iweek,Imonth,3months,6months,lyear after PCI.Results:HRV indices were decreased in patients with CAD,HRV was lower in patients in lweek after PCI than that before PCI,HRV was gradually increased in lmonth and there was significantly improved in 6months after PCI,and nearly to the level of control group in one year.Conclusion:HRV is low in the patients with CAD,there is slightly decreased in the early stage of PCl,but the long effect of PCI on heart rate variability can be observed.

Objective To explore the therapeutic effect of alpha-lipoic acid(ALA) combined with monosialotetrahexosylganglioside(GM1) in the treatment of diabetic peripheral neuropathy (DPN).Methods According to random number table,98 type 2 diabetic patients with DPN were divided into the control group and treatment group according to the principle of informed consent,each group 49 cases.The control group was treated with ALA 600mg/d by intravenous drip infusion once a day for 3 weeks.The treatment group was treated with ALA 600mg/d and GM1 60mg by intravenous drip infusion once a day for 3 weeks.The changes of nerve system symptoms and signs were observed before and after treatment,measurement of nerve conduction velocity (NCV) and fasting blood glucose,examination of knee tendon and Achilles tendon reflex,blood and urine routine and hepatic and renal function.Results The total effective rate of treatment group was 91.84％,which was higher than that of the control group (67.35 ％) (χ2 =52.01,P ＜ 0.05).After the treatment,the motor nerve conduction velocity (MNCV),sensory nerve conduction velocity(SNCV) of the treatment group increased significantly higher than those of the control group(t =1.987,1.972,1.972,1.972,all P＜0.05).Conclusion ALA combined with GM1 in the treatment of DPN is safe and effective.

Objective:To investigate the characteristics of brachial ankle pulse wave velocity(baPWV)in patients with essential hypertension,and that in patients with essential hypertension associated with coronary artery disease.Methods:The baPWV of 28 patients with essential hypertension was measured,the baPWV of 26 patients with essential hypertension associated with coronary artery disease confirmed by coronary angiography was also measured,and the baPWV of 25 control group's patients was measured.Results:baPWV was significantly higher in patients with essential hypertension than that in contral group,and baPWV is much higher in patients with essential hypertension associated with coronary artery disease than that in patients with essential hypertension.Conclusions:The results suggest that vascular lesion is exsist in patients with essential hypertension,and the vascular stiffness in patients with essential htpertension associated with coronary artery disease is increased than that in patients with essential hypertension.

Objective To backup data stored in Oracle database in No.1 Military Medical Project.Methods Oracle encryption features,such as encrypting table columns,encrypting Rman backupset,encrytpting datapump export data were utilized,to encrypt sensitive data stored in HIS of No.1 Military Medical Project.Results The encryption features effectively protected Oracle online data and backup data.Conclusion These methods are secure and feasible in practice.Optimum method can be selected to encrypt data in database according system security requirements.

Humans ; Laparoscopy

Objective To establish the quality standard for Lithospermum anti-inflammatory tablets.Methods Houttuynia,diffusa and grass coral in the prescription were qualitative identified by Thin Layer Chromatography(TLC) method.Results TLC spot features clear and specific.Conclusion The established standard can be used for quality control of Lithospermum anti-inflammatory tablets.

Objective To investigate the early variations and clinical value of serum delta bilirubin after orthotopic liver transplantation. Methods Orthotopic liver transplantation was performed in 27 cases.Of them,10 cases were uneventful;8 patients suffered from acute rejection.According to the outcome,18 patients (including 10 uneventful cases and 8 cases with acute rejection) survived while other 9 died.Daily determination of serum delta bilirubin was examined in all patients. Results The changing patterns of serum delta bilirubin were different between uneventful patients and those with acute rejection.For those uneventful patients,?B% tended to increase after operation.On the 21st day after transplantation,it reached(37.5?11.2)%.To the contrary,after acute rejection occurred,?B% decreased from basal level(26.4?9.8)% to(20.2?12.7)%(n=8,t=2.12,P=0.07).Serum concentration of total bilirubin (TB) and conjugated bilirubin (CB) significantly increased after acute rejection arose.The difference between peak and basal level of TB and CB was (150.3?113.2)?mol/L(n=8)and(118.5?93.4)?mol/L(n=8)respectively(t=3.75,P=0.007;t=3.59,P=0.009).On the 14th day after operation,?B% in patients with good outcome(n=18) significantly higher than that in patients who died(n=9)(33.4%?12.2% vs 22.0%?10.0%,t=2.42,P=0.02).Conclusions Two weeks after operations,?B% is correlative to the outcome of the patients.But as for the diagnosis of the acute rejection,?B% shows no advantages over serum TB or CB.