Objective To study the CT features of pulmonary inflammatory pseudotumor so as to distinguish from spherical lesion of lung cancer,tuberculoma and sperical pneumonia.Methods We investigated retrospectively the data of the 31 cases with pulmonary imflammatory pseudotumor which were proved pathologically after surgery.Results The main CT findings were as follows:(1)circle-like mass,most of them were single,margin was smoothy,density was even,diameter was about 32.0 cm.(2)There were localized pleural thickening adhesion and strip-like low density lesion between mass and thickened chest wall.(3)The middle sections showed:lateral margins of the lesions perpendicular to pleura with a straight cut edge.(4)The edge of the lesion presented short and thick spiculation.Conclusion CT examination is very helpful to the correct diagnosis of pulmonary inflammatory pseudotumor.

The study aimed to establish a population pharmacokinetic/pharmacodynamic (PPK/PD) model of warfarin. PCR-RFLP technique was used to genotype the CYP2C9 and VKORC1 polymorphisms of 73 patients. RP-HPLC-UV method was used to determine the 190 plasma concentrations of warfarin. Application of NONMEM, the clinical information and 263 international normalized ratio (INR) monitoring data were used to investigate the effect of genetic, physiological, pathological factors, other medication on clearance and anticoagulant response. The final model of warfarin PPK/PD was described as follows: CL = θCL · (WT/60)θWT · θCYP · eηCL (if CYP2C9*1/*1, θCYP = 1; if *1/*3, θCYP = 0.708); EC50 = θEC50 · θVKOR · eηEC50 (if VKORC1- 1639AA, θVKOR = 1; if GA, θVKOR = 2.01; V = θV; K(E0) = θK(E0); Emax = θEmax; E0 = θE0 · eηE0. Among them, the body weight (WT), CYP2C9 and VKORC1 genotype had conspicuous effect on warfarin PK/PD parameters. The goodness diagnosis, Bootstrap, NPDE verification showed that the final model was stable, effective and predictable. It may provide a reference for opitimizing the dose regimen of warfarin.