1.Nosocomial Infection in 169 Puerperal Women:Clinical Analysis
Chinese Journal of Nosocomiology 2004;0(10):-
OBJECTIVE To investigate the clinical characteristic and counter measure of nosocomial infection in puerperal women.METHODS The data of nosocomial infection in puerperal women from Jan 2004 to Dec 2007 were analyzed.RESULTS Among all puerperal women,169 (1.12%) were infected,from them 96 cases were infected in respiratory tract(56.80%);28 cases in operative incisional wound(16.57%);17 cases in gastrointestinal tract(10.06%);7 cases in urinary tract(4.14%);and 3 vases in cavity of uterus(1.78%).CONCLUSIONS Puerperal women are high risk group of nosocomial infection because of strength depletion,blood loss and perinatal injury.Paying attention to aseptic manipulation,making the rational use of antimicrobial agents and properly nursing can effectively decrease the incidence of nosocomial infection.
2.Prognostic factors of the invasion and metastasis of gastric cancer and their applications in targeted therapy
International Journal of Surgery 2011;38(10):707-710
Invasion and metastasis are critical determinants on cancer morbidity.Genes and molecules participating in these steps have been demonstrated as potential prognostic factors.Growth factors and their receptors,cell-cycle regulators,cell-adhesion molecules and m trix-degrading enzymes are potentially used as prognostic factors.However,increased understandings for molecular mechanisms underlying carcinogenesis and its implementation in the treatment of gastric cancers have recently been focused on the development and incorporation of targeted agents with chemotherapy.
3.Progress and prospects of research on information processing techniques for intelligent diagnosis of traditional Chinese medicine
Journal of Integrative Medicine 2006;4(6):560-6
Information processing for intelligent diagnosis of traditional Chinese medicine (TCM), an important part of the modernization of Chinese medicine, attracts world wide attention from the science circle. This article presents a systematic introduction to the development of information technology, especially the processing of pulse and tongue images and systems of computer-aided Chinese medical diagnosis. Furthermore, it points out four essential areas of future research, including epistemic logic system of syndrome differentiation, system construction technology, data miming technology and information acquisition and analysis in TCM diagnosis.
4.Non-dispensed drug Inquiry based on middle database of ACCESS
Chinese Medical Equipment Journal 1989;0(03):-
Middle database of ACCESS is used to develop non-dispensed drug inquiry system. Current Oracle data structure is not destroyed and the requirements of hospitals can be satisfied.
5.The roles of C-reactive protein and pleural effusion in prognosis evaluation in the early stage of acute pancreatitis
Heping XIANG ; He LI ; Changle ZHANG
Chinese Journal of Emergency Medicine 2011;20(8):820-823
ObjectiveTo investigate the values of C-reactive protein (CRP) and pleural effusion in predicting the severity in the early stage of severe acute pancreatitis (SAP) . Methods A total of 89patients with acute pancreatitis were collected from October 2008 through October 2010 for retrospective analysis. Patients were divided into two groups, namely mild acute pancreatitis (MAP) group and SAP group as per the Guidelines for Clinical Diagnosis and Classification of Acute Pancreatitis set by the Society of Chinese Medical Association in 2003. The levels of CRP were measured on the 1st, 2nd, 3rd and 7th days after admission. Pleural effusion was also observed on the 1 st day after admission. The data of two groups were analyzed and compared. ResultsThere were significant differences in CRP at all intervals between SAP group and MAP group (P <0.05) . The relative risk of increase in CRP ( > 150 mg/L),pleural effusion and increase in CRP along with pleural effusion were analyzed, and each of these three markers can be used as an independent severity factor of SAP. Particularly, increase in CRP along with pleural effusion could be most sensitive in predicting the severity of SAP with relative risk (RR) to be 4. 8 and specificity of predictive value to be 100%. ConclusionsC-reactive protein and pleural effusion are available, simple and economic biomarkers which can help us predict the risk of acute pancreatitis in the early stage.
6.Design and implementation of an automatic palpation device
Zhaohui WANG ; Zhifeng ZHANG ; Changle ZHOU
International Journal of Biomedical Engineering 2013;(2):80-83
Objective To realize objectification and detailed quantification of palpation.Metbods A kind of automatic palpation device was developed to meet the needs of safeand easy operation,technique simulation,and multi-parameter monitoring in real time.Results This device mainly consisted of programmable controller and its analog-to-digital converter module,mechanical positioning device,pressing device,force testing device and hand-held touch screen,and it was designed to be operated by attenders independently.The device could collect multiple data including force,time and distance in the process of palpation,and monitor the force thresholds of pressing responses at all levels to achieve desired effects.Conclusion This device can be used in the automatic palpation for suitable body areas,especially in the comprehensive observation of acupoint-pressing responses or soft tissue tenderness.
7.Effects of various surgical procedures on portal hemodynamics in patients with portal hypertension
Shuguang ZHANG ; Changle RUAN ; Zhenhai YU
Chinese Journal of General Surgery 1993;0(03):-
ObjectiveTo study the effects on hemodynamics of portal venous system of splenorenal shunt plus pericardia devascularization (SRS+PCDV), and evaluate the clinical significance of this operative procedure.MethodsThe hemodynamic parameters of portal venous system by Doppler color-flow imaging (DCFI) of 99 patients with portal hypertension (PH) were measured before and after operation.Results(1)In SRS group the postoperative portal venous flow (PVF), free portal pressure(FPP) decreased by (57?9)%, (52?5)% respectively (P0.05).(3)In SRS+PCDV group PVF,FPP decreased by (36?8)%, (34?10)% respectively(P
8.Relationship Between Plasma Insulin,Serum Lipids and Cholelithiasis in Patients With Type 2 Diabetes
Daolin HUANG ; Changle ZHANG ; Weilong ZOU
Journal of Chinese Physician 2000;0(11):-
Objective To investigate the level changes of plasma insulin,serum lipids in type 2 diabetes with cholelithiasis.Methods 159 cases of types 2 diabetic patients was studied during recently 3 years in our department of endocrinology,the levels of blood glucose,plasma insulin and insulin sensitivity index(ISI),serum lipids,apolipoproteins(ApoA 1,B) were measured both fasting and post-prandial,and investigated their correlation between type 2 diabetic patients with cholelithiasis(n=103) and without cholelithiasis(n=56).Results Female was predominated in fifty-six diabetic with cholelithiasis,they had higher triglyceride(TG),fasting or post-prandial insulins,ApoA 1,ApoB,the top body weight index and lower ISI than 103 diabetics without cholelithiasis.There were no significant differences in total cholesterol(CH),HDL-Ch,LDL-Ch,blood glucose concentrations between the groups.Conclusions Obesity,insulin resistance and lipids metabolic disturbance might be related to the development of cholelithiasis in type 2 diabetic patients.
9.Long-term effect of combined portoazygous devuscularization and shunt for treatment of portal hypertension.
Shuguang ZHANG ; Changle RUAN ; Zhenhai YU ; Guangxing LI ; Zhaoting LI
Chinese Journal of Practical Surgery 2001;21(3):147-148
ObjectiveTo evaluate the therapeutic effect of combined portoazygous devascularization and shunt on portal hypertension. MethodsThe data of 56 cases of portal hypertension treated with portoazygous devascularization and shunt from April 1987 to April 1999 was summarized. ResultsThere was no death in 54 patients receiving selective operation;of 2 cases receiving emergency operation, one died. Among 49 followed-up cases, there was one rebleeding,2 hepatic encephalopathy, and one died of liver failure 4 years after opeation. The mean portal pressure before and after operation was(3.42±0.46) kPa and (2.50±0.35) kPa, respectively. ConclusionCombined portoazygons devascularization and shunt not only decreases portal pressure but preserve hepatic blood flow to some extent.
10.Clinical significance and changes on serum levels of α-MSH, TNF-α, PCT in patients with acute pancreatitis
Ming GAO ; Heping XIANG ; Changle ZHANG ; Rui FU
Chinese Journal of Emergency Medicine 2015;24(4):431-434
Objective To investigate the dynamic changes in peripheral blood of patients with acute pancreatitis α-MSH,TNF-α,PCTS and the value of the patient assessment of disease severity.Methods Emergency surgery in the Second Affiliated Hospital of Anhui Medical University from March 2011 to March 2014 were treated 68 cases of acute pancreatitis patients,36 patients with mild,32 cases of severe group.All patients were extracted 1,3,5,7 days after admission blood,and α-MSH was measured by enzymelinked immunosorbent assay,the content of TNF-αand PCT.Results Compared with the mild group,the serum of patients with severe group of α-MSH concentrations were lower (P < 0.05),while serum TNF-αand PCT levels higher than the mild group (P < 0.05);in disease severity assessment,α-MSH sensitivity of 82.35% and a specificity of 88.24%,the accuracy was 87.5%,TNF-α sensitivity of 76.47% and a specificity of 82.35%,the accuracy was 81.25%,PCT sensitivity of 70.59% and a specificity of 76.47%,75.00% accuracy,PCT + TNF-α + α-MSH sensitivity of 88.24% and a specificity of 94.12%,93.75% accuracy;area under the PCT,TNF-α,α-MSH and the combination of the three curves 0.690,0.696,0.768 and 0.885,respectively.Conclusions Serum α-MSH,monitoring TNF-α,PCT levels have some clinical value in patients with acute pancreatitis disease severity assessment,including α-MSH in the condition assessment of the sensitivity,specificity and positive predictive value were higher than the latter two,and peripheral α-MSH in patients with a low level indicates a serious condition,poor prognosis;addition,combined detection with higher clinical value in the assessment of disease severity.