Objective To investigate the effect of anterior cervical discectomy and interbody fusion ( ACDF) combined with titanium plate fixation technique and subtotal vertebrectomy and fusion and titanium plate internal fixation operation ( ACCF) on adjacent segmental cervical spondylotic myelopathy. Methods 76 patients with double segment spondylotic cervical myelopathy were randomly divided into AC-CF group and ACDF group,the relevant indicators of operation period,spinal cord function,anteroposterior and lateral of cervical spine and flexion-extension dynamic radiographs were observed,the Cobb’ s angle and fusion segmental height and bone fusion were recorded. Results The operation related index results showed that the operation time,bleeding volume and hospitalization time of patients in ACDF were less than those in ACCF group (P< 0. 05). The bone graft fusion rate of two groups was 100%. There was no significant differences in postopera-tive fusion segment height between two groups (P> 0. 05). The postoperative Cobb’s angle degree of ACDF group is better than that of AC-CF group (P<0. 05). Conclusion The effect of ACCF and ACCF on the treatment of two-level CSM were satisfactory,of which ACDF has the advantages of short operation time,less bleeding,fusion segments of Cobb’ s angle and fewer complications.

Objective To explore the feasibility of the Coapresta2000 automatic coagulation analyzer for detecting C‐reactive protein(CRP) .Methods The performance of the Coapresta2000 automatic coagulation analyzer for detecting CRP was analyzed ,in‐cluding accuracy ,linearity ,precision ,carryover rate and the correlation between the Ottoman automatic special protein real time ana‐lyzer and the Coapresta2000 automatic coagulation analyzer .Results The men recovery rate of 3 batches of reagent by the Coapres‐ta2000 automatic coagulation analyzer for detecting CRP for detecting plasma CRP was 106 .0% with better accuracy ;the within‐run precision was less than 10% and the inter‐day precision was less than 15% ;the carryover rate was 0 .32% ;the related equation in the Ottoman automatic special protein real time analyzer and the Coapresta2000 automatic coagulation analyzer for detecting plas‐ma CRP was Y=0 .001 2X+0 .489 ,the correlation coefficient was r2 =0 .997 5 ,the difference was not statistically significant(P>0 .05) .The CRP results of plasma sample detected by these two instruments was highly correlative ;the linearity in the Coapres‐ta2000 automatic coagulation analyzer for detecting CRP was 0-200 mg/L .Conclusion The Coapresta2000 automatic coagulation analyzer for detecting CRP has better within‐run precision ,low carryover rate ,high correlation with the Ottoman automatic special protein real time analyze ,which has a value for further study .

Objective To explore discussion medical treatment in massive hemoptysis emergency surgical treatment.Methods Hemorrhage parts,timing of surgery,pneumonectomy scope in 24 cases of massive hemoptysis were analyzed.Results 24 cases of massive hemoptysis emergency surgical treatment were successful,no death and complication rate was 8.3% (2/24).Conclusion For medical treatment ineffective massive hemoptysis determine the location of the bleeding,actively carry out preoperative preparation, choosing the best opportunity emergency resection of lung disease,can be effective in reducing mortality.

Adult ; COVID-19/prevention & control* ; Cross Infection/prevention & control* ; Female ; Health Personnel/statistics & numerical data* ; Humans ; Male ; Middle Aged ; Respiratory Tract Diseases/virology* ; SARS-CoV-2 ; Taiwan/epidemiology*

Although agomelatine may be associated with an increased risk of hepatotoxicity, the incidence rate of acute hepatitis seemed divergent between clinical trials and daily practice. Whether aging or gender is a risk factor in developing hepatotoxicity due to agomelatine is not clear. We present 3 older female cases with acute hepatitis occurring due to highly probable idiosyncratic drug-induced liver injury caused by agomelatine. From these cases, regular surveillance on liver function in the older women taking antidepressants would be of benefits.

Objective To observe the effects of different doses of human recombinant tissue factor pathway inhibitor-1 (TFPI-1) on no-reflow (NR) phenomenon in rabbit.Methods Fifty-two New Zealand white rabbits were subjected to coronary artery occlusion for 120 min and followed by reperfusion for 60 min,and then were randomly (random number) assigned into four groups:control group,large,moderate and low doses TFPI-1 groups ( 1000 ng/kg,100 ng/kg,10 ng/kg bolus and thenl0 ng/kg,1 ng/kg and 0.1 ng/kg per minute infusion for maintenance,each group n =13).The no-reflow area (NA) and ischemic area (IA) was measured by thioflavin S and Evan's blue.The NR severity was expressed by NA/IA.The difference in NR severity was compared between groups.The thrombi and myocardial injury were observed under light microscope.The infarction and NR severity in different groups were compared by using one-way ANOVA followed by LSD procedure.Results There were no significant differences in IA and body weight among four groups (P＞0.05).NR severity in the large,moderate,low doses TFPI-1 groups and control group were (0.210 ±0.061 ),(0.389 +0.110),(0.478 ±0.077) and (0.536 ±0.061 ),respectively.NR severity in the large dose TFPI-1 group was slightest among the four groups (P ＜0.01 ).NR severity in the moderate dose TFPI-1 group was significantly decreased than that in control group ( P ＜ 0.01 ) and in low dose TFPI-1 group (P ＜0.05 ).There was no significant difference in NR severity between the low dose TFPI-1 group and control group ( P ＞ 0.05 ).There was less thrombus formation and lower grade myocardial injury found in the large dose TFPI-1 group. Conclusion Human rTFPI-1 might lessen NR severity in rabbit in dose-dependent,suggesting the option on human rTFPI-1 for treatment of NR phenomenon.

Objective To observe the function of recombinant human tissue factor pathway inhibitor1(rTFPI-1)in acute myocardial infarction in rabbit. Method Forty New Zealand White rabbits were subjected to coronary artery occlusion for 120 min and followed by reperfusion for 60 min,then they were ranlow dose rTFPI-1 group(n=10/group).The extent of ischemic area and the extent of myocardial infarction area were measured by Evan's blue stain and TTC stain,respectively.The degrees of infarction severity and ischemic severity were expressed as the ratios of the total left ventrieular wall area.The degrees of infarction severity and ischemic severity in different groups were compared by using one-way ANOVA and then followed by LSD procedure.Results The degree of infarction severity in the larger dose rTFPI-1 group was significantly lessened than that in low dose RTFPI-1 group and control group(P<0.001),and than that in modcrate dose rTFPI-1 group as well(P<0.05).The degree of infarction severity in the moderate dose rTFPI1 group was significantly lessened than that in low dose rTFPI-1 group and control group(P<0.001).There was no significant difference in degree of infarction severity between low dose rTFPI-1 group and control group(P>0.05).Conclusions Human rTFPI-1 might decrease myocardial infarction severity and save the survival myocardial tissue.

OBJECTIVE: To analyze the cost-effectiveness of 3 different therapeutic regimens for chronic urticaria.METHODS: 3 oral therapeutic regimens including regimen A(triprolidinen plus ranitidine),regimen B(levocetirizine),and regimen C(levocetirizine plus antipruritic) were analyzed using cost-effectiveness analysis.RESULTS: The total costs of regimen A,B,and C were 91.96 yuan,54.16 yuan and 356.56 yuan,respectively;The effective rates were 76.09%,74.00% and 91.84%,respectively;The cost-effectiveness ratios were 120.86,73.19 and 388.24,respectively.As compared with regimen B,the incremental cost-effectiveness ratios for regimen A and C were 1 808.61 and 1 695.07,respectively.CONCLUSION: Regimen C is the preferable one in terms of the cost-effectiveness.

Papillary thyroid carcinoma is the most common pathology type of thyroid carcinoma with the following biological characteristics:low malignancy,slow progress,longer duration,good prognosis,but it is prone to lymph node metastasis.Lateral lymph node metastasis relates with patients' age,sex,tumor size,tumor location,capsular invasion/extra-thyroidal extension,muli-focality and the number of positive central lymph nodes.Understanding the influencing factors of the lateral lymph node metastasis has important clinical significance for determining the lymph node dissection scope and the indications for the patients with thyroid carcinoma.

AIM: To observe the effect of Qingluo Tongbi Granule(QLTBG)——containing serum on the proliferation of osteoblasts(OB) and osteoclasts(OC),the activity of AKP of OB. METHODS: (1) OB were separated from the skull of SD rats aged 1 d and OC from the thighbone and shinbone of SD rats aged 5 d.(2) The proliferation of OB and OC was detected by MTT method,and the activity of AKP of OB was examined by diazol method. RESULTS: The proliferation capability of OB was strengthened markedly by the rat sera containing 7.2,14.4 g/kg QLTBG,which could reinforce the activity of AKP obviously as well,while the proliferation of OB was inhibited remarkably by the rat sera containing 3.6,7.2,14.4 g/kg QLT. CONCLUSION: The sera containing QLTBG could enhance the proliferation of OB and the activity of AKP,restrain the proliferation of OC simultaneously.