Benzylisoquinolines ; therapeutic use ; Calcium Channel Blockers ; therapeutic use ; Combined Modality Therapy ; Humans ; Pneumoconiosis ; drug therapy ; Tablets

The inhibitory effects of growth-inhibitor on the growth of Isochrysis galbana, malondialdehyde (MDA) content and activities of antioxidant enzymes (superoxide dismutase and peroxidase) were studied. And the inhibition effects of 4 species of antioxidants on this damage to its cells were also investigated. The results showed that 0.10 mg/L of GI marked decreased cell densities, activities of superoxide dismutase (SOD) and peroxidase (POD), and MDA content increased. With increase of GI concentrations, cell densities and activities of SOD and POD decreased sharply, and MDA content increased obviously. When concentration of GI was 0.30 mg/L, the cell densities, activities of SOD and POD decreased to 0.05, 0.56 and 0.59 folds of the control, respectively, and MDA content increased to as higher as 2.2 folds of that of the control set. L-Ascorbic acid, citrazinic acid, lenediamiaetetraacetic acid disodium salt (Na2EDTA) and 3-tert-butyl-4-hydroxyanisole could decrease MDA content obviously, and marked increased cell densities and activities of SOD and POD. When 4 species of antioxidants were added to the medium, the cell densities, and activities of SOD and POD increased to as high as 1.38～1.90, 1.49～2.12 and 1.55～2.13 folds of that of the control set, respectively, and MDA content decreased by 57.7%～87.9%. It was indicated that the excess active oxygens were produced under growth-inhibitor stress and active oxygen participated in the damage of growth-inhibitor to Isochrysis galbana; the L-ascorbic acid, citrazinic acid, lenediamiaetetraacetic acid disodium salt and 3-tert-butyl-4-hydroxyanisole could effectively inhibit membrane lipid peroxidation and further alleviated algal damage.

Objective To analyze the correlation between Uyghur metabolic syndrome and northwest dryness syndrome in Kashgar prefecture, Xinjiang. Methods Case-control design was used to include a total of 120 cases from the First People’s Hospital of Kashgar Prefecture, Xinjiang. They were selected as the case group, and 120 cases without diseases of Western medicine were as the control group. The northwest dryness syndrome was statistically analyzed. Results The total integral of northwest dryness syndrome in case group was (11.49±0.89) and that in control group was (5.84±0.81), and the case group was higher than the control group with statistical significance (P<0.01). By comparing various accompanied symptoms, except for the fire & wind dryness syndrome of lung&heart&spleen as well as lung&stomach yin deficiency syndrome, all the other syndromes in case group were higher than those in control group (P<0.01). The attack rate of northwest dryness syndrome in case group was 24.17% (29/120), higher than that in control group (7.50%, 9/120), with significant difference (P<0.01). In the correlation analysis between the state of TCM syndrome and northwest dryness syndrome in case group, spleen yin deficiency syndrome of metabolic syndrome had the strongest correlation with damp accumulation syndrome of northwest dryness syndrome (P<0.01), followed by liver-qi stasis syndrome and heart&kidney yin deficiency syndrome (P<0.01). Conclusion Metabolic syndrome is often concomitant with northwest dryness syndrome in Kashgar prefecture, Xinjiang. Moreover, the severity of clinical symptoms of metabolic syndrome was associated with the state of northwest dryness syndrome, which provides clinical epidemiology basis for developing prevention and cure strategy of metabolic syndrome in Xinjiang from the perspective of“treating the different diseases with the same therapy”.

Objective To measure the levels of neutrophil elastase (NE),citric acid and pH in prostatic fluid of patients with prostatitis type Ⅲ.Methods Fifty two patients with prostatitis type ⅢA,98 patients with prostatitis type Ⅲ B and 105 health subjects were enrolled in the study.The levels of NE,citric acid and pH in prostatic fluid were measured ; the expressed prostatic secretion (EPS) routine and bacterial culture were examined,and National Institutes of Health (NIH)-chronic prostatitis symptom index (NIH-CPSI) was evaluated.The data were analyzed by independent samples t-test.Results WBC count,NE and citric acid concentrations,pH in ⅢA group were (17.9 ±5.4)/HP,(898 ±704) μg/L and (14.5 ± 1.7) ng/L,7.60 ±0.43,respectively; those in ⅢB group were (3.9 ±2.2)/HP,(93 ±76) μg/L and (21.9 ±3.8) ng/L,6.71 ±0.25,respectively; those in control group were (3.6 ±2.2)/HP,(86 ±57) μg/L and (22.5 ± 3.9)ng/L,6.48 ± 0.51,respectively.There were significant differences in NE and citrate concentrations,pH value in EPS between Ⅲ A and Ⅲ B patients (t =8.22,16.64 and 13.88,all P ＜0.05),but no difference in NIH-CPSI (t =1.90,P 8 0.05).There were significant differences in WBC count,NE and citric acid concentrations,pH in EPS,NIH-CPSI score between Ⅲ A and control groups (t =18.92,8.47,26.53,18.37 and 32.47,all P ＜ 0.05).There were no differences in WBC count,NE and citric acid concentration and pH value in EPS between Ⅲ B group and control group (t =1.38,1.55,1.02 and 1.21,respectively,all P 80.05),but there was significant difference in NIH-CPSI score between two groups (t =49.46,P ＜ 0.05).In EPS,NE concentration and WBC count were positively correlated with NIH-CPSI (r =0.819 and 0.698,respectively,all P ＜0.01),and citric acid was negatively correlated (r =-0.625,P ＜ 0.01) ; citrate was negatively correlated with WBC count,CPSI and pH value (r =-0.728,-0.644 and-0.817,all P ＜ 0.01).Conclusions The results indicate that the measurements of NE,citric acid and pH in EPS are of significant clinical value in patients with prostatitis type ⅢA and Ⅲ B.

BACKGROUND:Cam-type femoroacetabular impingement can impose elevated mechanical loading in the hip, and may eventual y result in hip osteoarthritis, while mechanical mechanism on how this deformity leads to osteoarthritis is stil unclear.
OBJECTIVE:To analyze intra-articular mechanical environment of Cam-type femoroacetabular impingement in hip joint using three-dimensional finite element method, and to further understand the features of pathological mechanics.
METHODThree-dimensional geometry models of normal and Cam-type femoroacetabular impingement joints were constructed using Mimics and Hypermesh software with the CT data of normal hip joint. These hip models were imported into LS-DYNA analysis system, then dynamic loads and motions for standing up and sitting down were applied to al joint models. Intra-articular cartilage contact pressures and stresses were analyzed in normal hip joint and hip joint with Cam-type femoroacetabular impingement.
RESULTS AND CONCLUSION:Based on CT data, models of normal hip joint and hip joint with Cam-type femoroacetabular impingement including articular cartilage for three-dimensional finite element analysis were accurately constructed. Peak contact pressures were 4.43 and 4.59 MPa at the anterosuperior region of the acetabular rim during sitting down and standing up. The peaks of Cam-type femoroacetabular impingement hip joint were 14.96 and 14.86 MPa. Peak pressures and stress concentration were found at the anterosuperior area of acetabular rim. High contact pressure at the acetabular cartilage may be the mechanical mechanism of osteoarthritis induced by Cam-type femoroacetabular impingement.

Objective: To assess the peculiarity in fluorine-18 fluorodeoxyglucose (FDG) uptake in patients with bronchial alveolar carcinoma. Methods: From December, 1998 to April, 2002, 22 patients with bronchial alveolar carcinoma (BAC) were imaged with FDG-PET (positron emission tomography) before surgery. Their maximum and mean standard uptake value (SUVmax and SUVmean ) of tumor and SUV of normal lung (SUVlung) were measured. Results: All tumors were detected by FDG-PET. FDG uptake of tumor was higher than that of normal lung (P

Objective To assess the risk factors of adrenal incidentalomas during follow up. Methods In 43 patients with adrenal incidentalomas, the significant risk factors were screened by univariate analysis, and the multivariate analysis was evaluated by logistic regression. Results After an average of (4.0?1.2)years of follow up,4 out of in 21 patients with adrenalectomy were verified to be malignant. By means of multivariate analysis, tumor size ( P =0.018)and abnormal level of hormonal or its metabolic products ( P =0.039)were the risk factors for adrenal incidentalomas and adrenalectomy should be considered when indicated. Conclusions The gains and losses of open surgery for adrenal incidentalomas should be weighed up.If the evaluation of risk factors reveals a possibility of malignancy,adrenalectomy should be undertaken.

Objective To investigate the clinical characteristics and prognostic factors of peripheral T-cell lymphoma (PTCL) in elderly patients. Methods The complete clinical data of 59 patients out of 63 cases of elderly PTCL patients, who were admitted to the Hematology Department of Shanghai Changhai Hospital from January 2005 to May 2013, were collected, and the clinical features of these patients, who were followed-up for 33 months (1-99 months), were retrospectively analyzed. SPSS 22.0 was employed for the statistical analysis, survival analysis was performed by Kaplan-Meier method, and then the Log-rank test was done, the survival rate was calculated with life table method, and the COX proportional hazard model was used to perform multivariate analysis. Results The median survival time was 13 months, and the expected 1-year, 2-year and 3-year overall survival rate (OS) was 47%, 41% and 30%, respectively. Univariate analysis showed that the serum lactate dehydrogenase (LDH, P<0.001), serum ß2-microglobulin (P<0.001), PS score (P<0.001), IPI points (P<0.001), bone marrow involvement (P=0.011), extranodal involved sites (>1) (P<0.001), Ki-67 percentage (P<0.001), as well as the efficacy and course of chemotherapy (P<0.001) were all the prognostic indicators affecting the survival time in this cohort of elderly patients. Multivariate analysis indicated that PS score, IPI points, extranodal involved sites (>1), the efficacy and course of chemotherapy were the independent prognostic indicators affecting the survival time (P<0.05) Conclusions PS score, IPI points and extranodal involved sites (>1) are of great significance for predicting the prognosis in elderly PTCL patients. The completion of a certain intensity of chemotherapy to achieve remission is an important measure to prolong survival time in elderly PTCL patients.

OBJECTIVE: To investigate and analyze the prophylactic usage of antibiotics in clean surgical operations in 110 hospitals. METHODS: The prophylactic usage of antibiotics in clean surgical operations in 110 sample hospitals was obtained from the regional medical big data center, and then evaluated with the traditional statistical methodand the technique for order preference by similarity to ideal solution (TOPSIS) method, respectively. RESULTS: The total number of patients receiving clean surgical operations enrolled into this analysis was 139617, among whom the average prophylactic usage rate of antibiotics was 41.87%. The average prophylactic usage rate of antibiotics in the highlighted 10 kinds of clean surgical operations was 17.08%, with the highest usage rate (higher than 80%) in tubal surgery, craniotomy surgery, and hip replacement surgery. CONCLUSION: The traditional statistical methods can only reflect some aspects of the usage of antibiotics in clean surgical operations, and the TOPSIS method is more suitable for hospitals to evaluate the general usage of antibiotics. Combined usage of the two methods can objectively reflect the medical quality of hospitals.

Objective To implement XML-based electronic medical records' searching and querying using new technology of XML storing and indexing.Methods The information in electronic records was expressed with CDA XML standard,and XML Query and XML IR were used for querying of electronic records.Results Based on XML querying and indexing models,a new electronic medical record XML querying and searching system was built.Conclusion Querying and searching over XML database has been paid more attention to,with wide use of data adapting to HL7 CDA XML standard in electronic medical records.