The relaxation therapy is a common method in the psychological rehabilitation in the injured and disabled patients,which can release the negative emotions,improve the quality of sleep,decrease the pain of the injured and disabled parts of the body and build up the confidence of life of the patients after the earthquake.After the long-term practice of the psychological rehabilitation in the injured and disabled patients and the experience of the psychological rehabilitation in the injured and disabled patients after the 5·12 Earthquake,the author thinks during the relaxation training psychotherapy of the injured and disabled patients after the earthquake,the choice of technique and procedure of the relaxation therapy should depend on the specific situation of the patients.The author introduces a idiographic method of the relaxation therapy and some suggestions of the implied treatment after the relaxation which is suitable for the injured and disabled patients.

The earthquake always results in a great number of the injured and disabled patients.So timely and effective psychological rehabilitation interventions are very helpful,especially for those survivors to relieve their psychological traumatic response caused by the earthquake,and renew their healthy psychological situation.The present article analyzes the chief psychological symptoms and influencing factors of the injured and disabled patients after the earthquake,and further provides some principles and strategies for the psychological rehabilitation,such as how to cope with the early stress response(anxiety,depression,self-abasement,and so on),or how to deal with the social phobia.

Objective To investigate the effects of miR-10a expression on migration and invasion of human pancreatic cancer cells AsPC-1.Methods Small interfering RNA targeting at miR-10a (miR-10a-siRNA) was constructed,then it was transfected into pancreatic cancer AsPC-1 cells,and nonsense siRNA (Nc-siRNA) group and blank control group was established.Real time PCR assay was used to detect the expression of miR-10a in the 3 groups,and wound healing assay and Transwell assay were used to determine the migration and invasion abilities of cancer cells.The amount of matrix metalloproteinase-13 (MMP-13) in supernatant of cancer cell culture of each group was examined by ELISA assay.Results The miR-10a levels in control group,NC-siRNA group and miR-10a-siRNA group were 1.05 ±0.08,1.03 ±0.06,0.02 ±0.01 ; and the number of transmembrane cell were (150 ± 2.6),(145 ± 2.2),(62 ± 1.8),the levels of MMP-13 in the supernatant were (108.5 ± 2.8),(107.8 ± 2.5),(35.8 ± 1.5) pg/ml.The values were significantly lower in miR-10a-siRNA group than those in control group and NC-siRNA group (P ＜ 0.01).The distance of cultured clone in miR-10a treated cancer cells (736± 18 μm) was significantly longer than those in the controls (385 ±5 μm) and NC-siRNA group (395± 13 μm,P＜0.01).Conclusions Down-regulation of miR-10a by siRNA may inhibit migration and invasion of pancreatic cancer AsPC-1 cells,and the downregulated expression of MMP-13 may be one of the important mechanisms.

ObjectiveTo explore the state of intelligence and adaptive behavior of children with cerebral palsy and the correlation between them.Methods169 children with cerebral palsy were evaluated with Wechsler Intelligence Scale for Children (Chinese version) and the Infants-Junior Middle School Students' Social-Life Abilities Scale for the intelligence and the adaptive behavior.ResultsThe average scores of verbal intelligence quotient (VIQ), performance intelligence quotient (PIQ) and full intelligence quotient(FIQ) of the patients were lower than the normal children and the average scores of PIQ and FIQ were less than 70; the PIQ deficiency was significant more than the VIQ deficiency(P<0.001). 93 cases had mental deficiency, including 43(46.23%) for mild, 36(38.71%) for moderate, 13(13.98%) for severe, 1(1.08%) for extreme severe. There were 113(66.86%) for the deficiency of full social-life abilities, 104(61.54%) for Self-Help, 147(86.98%) for Locomotion, 133 (78.70%) for Occupation, 73 (43.20%) for Communication, 115(68.05%) for Socialization, 90 (53.25%) Self-Direction. The damage of Locomotion was the most serious, while the damage of Communication was the least serious. The outcomes of Wechsler Intelligence Scale was significantly correlated with the Infants-Junior Middle School Students' Social-Life Abilities Scale(P<0.001).ConclusionThe cerebral palsy causes not only intelligent damage, but also intelligence deficiency in most patients and the major level of the intelligent deficiency is mild to moderate. The damage of the performance intelligence has more influence on the full scale intelligence in the children with cerebral palsy. Most of the children with cerebral palsy have inconsistent deficiency of different aspects of the adaptive behavior.