In the treatment of 48 cases of menopause syndrome by moving cupping therapy along the pathways of the bladder meridian, Jiaji points (Ex-B 2) and pathway of the Governor Vessel, the results showed cure in 10 cases, remarkable effect in 27 cases, effect in 8 cases and failure in 3 cases, and the total effective rate in 93.7%. In comparison with before the treatments, all the symptoms were relieved (P＜0.05) after treatments, with insomnia, poor memory, depression and easy crying, warm sensation in the five body parts, aching and soft sensation in the low back and knee relieved more remarkably (P＜0.01).

ObjectiveTo analyze the correlation between complete blood count （CBC）， glycosylated hemoglobin（GHbA1c）and thyroid function in late pregnancy on Tibetan Plateau. MethodsA retrospective analysis was performed on 374 patients of single pregnancies who had delivered in the department of Obstetrics and Gynecology， Chaya People's Hospital， Changdu City， Tibet Autonomous Region， between January 1， 2021 and December 31， 2021. All subjects completed CBC， GHbA1c and total triiodothyronine（TT3）， total thyroxine（TT4）， thyroid stimulating hormone（TSH）before delivery. According to the altitude of long-term residence， they were divided into three groups： the altitude of group A is <3500 m； the altitude of group B is 3 500~4 000 m； and the altitude of group C is ＞4 000 m. The anemia of Tibetan pregnant women in late pregnancy before and after adjustment， the levels of CBC， GHbA1c and thyroid function in different altitudes， and their correlations were analyzed. Results① The mean actual hemoglobin（HB）was 120.0（108.0~130.0）g/L， and the prevalence of anemia was 27.8%（104/374）. After adjustment， the mean HB was 93.0（80.0~104.0）g/L， and the prevalence of anemia was 84.3 %（315/374）； ② Actual HB levels increased with the rise of altitude， but the difference was not statistically significant（P>0.05）， and there was no difference among the three groups in the prevalence of anemia. After adjustment， HB levels showed a downward trends， while the prevalence of anemia increased with the rise altitude， and the difference was statistically significant（P＜0.001）. ③ Red blood cell count（RBC）and mean erythrocyte hemoglobin concentration（MCHC）increased， while TSH decreased with the rise of altitude， and the difference was statistically significant（P＜0.05）. ④ The actual HB and MCHC were positively correlated with TT4， GHbA1c was negatively correlated with TT4， and positively correlated with Platelet count （PLT）； spearman correlation analysis showed statistical significance（P＜0.05）. ConclusionsThe actual HB of Tibetan Plateau pregnant women in late pregnancy does not increase significantly with the rise of altitude. The prevalence of anemia increases significantly after adjustment according to the altitude. TSH decreases with the rise of altitude， and the altitude may have an effect on thyroid function in late pregnancy. Actual anemia in late pregnancy is associated with low T4， and low T4 and high PLT might be associated with increased GHbA1c. Actual HB， PLT and T4 in late pregnancy are expected to be predictors of thyroid disease and GDM.

OBJECTIVES: To investigate caries status and its impact factors in preschool children in plateau and to provide reference for caries prevention in highlands. METHODS: Examination of caries was performed on 1 597 children aged 3-5 years old in 11 kindergartens in Changdu, Xizang, in accordance with the 4th National Oral Health Survey standards and methods. Their parents were surveyed with the questionnaire regarding oral hygiene habit and consciousness about oral health and related factors. All the data were collected and analyzed. RESULTS: The prevalence of caries among children aged 3-5 years old in Changdu was 52.85%, with dmft index of 2.44. The caries rate and dmft of children aged 3 years old were lower than those of children aged 4 and 5 years old ( CONCLUSIONS The prevalence of ca-ries in children aged 3-5 years old in Changdu increases with aging. Good oral hygiene and eating habits and regular oral examination can reduce the rate of caries.
Child, Preschool ; Cross-Sectional Studies ; DMF Index ; Dental Caries/prevention & control* ; Dental Caries Susceptibility ; Female ; Humans ; Male ; Oral Health ; Oral Hygiene ; Prevalence

Objective: To evaluate the safety and efficacy of dental floss traction-assisted endoscopic submucosal dissection (DFS-ESD) for rectal neuroendocrine neoplasm (NEN). Methods: A retrospective cohort study was performed. Clinical data of rectal NEN patients undergoing ESD at Endoscopy Center of Zhongshan Hospital, Fudan University from January 2016 to December 2017 were retrospectively analyzed. Inclusion criteria: 1) age of 18 to 80 years old; 2) maximal diameter of lesions <1.5 cm; 3) tumor locating in the submucosa without invasion into the muscularis propria; 4) no enlarged lymph nodes around bowel and in abdominal cavity; 5) ESD requested actively by patients. A total of 37 patients were enrolled, including 23 male and 14 female cases with mean age of (56.0±11.3) years. All the lesions were single tumor of stage T1, and the mean size was 0.8±0.2(0.5-1.2) cm. Postoperative pathology revealed all samples as neuroendocrine tumors (NET). Seventeen patients received DFS-ESD treatment (DFS-ESD group) and 20 patient received conventional ESD treatment (conventional ESD group). In DFS-ESD group, after the mucosa was partly incised along the marker dots, the endoscopy was extracted, and the dental floss was tied to one arm of the metallic clip. When the endoscope was reinserted, the hemoclip was attached onto the incised mucosa; another hemoclip was attached onto normal mucosa opposite to the lesion in the same way. The submucosa was clearly exposed with the traction of dental floss and the resection could proceed. The conventional ESD group received the traditional ESD operation procedure. The operation time, modified operation time (remaining time after excluding the assembly time of dental floss traction in DFS-ESD group), en bloc resection rate, R0 resection rate, morbidity of operative complication, recurrence and metastasis were compared between two groups. Results: The average tumor size was (0.8±0.2) cm in DFS-ESD group and (0.7±0.2) cm in conventional ESD group (t=0.425, P=0.673). According to postoperative pathological grading of rectal neuroendocrine neoplasm, 13 were G1 and 4 were G2 in DFS-ESD group, while 17 cases were G1 and 3 cases were G2 in conventional ESD group without significant difference (P=0.680). There were no significant differences in baseline data between in the two groups (all P>0.05). All the basal resection margins were negative, the en bloc resection rate was 100% and the R0 resection rate was 100%. Pathological results showed tumor tissue close to the burning margin in 5 cases of conventional ESD group and in 2 cases of DFS-ESD group (P=0.416). The operation time was (17.9±6.6) minutes in conventional ESD group and (14.7±3.3) minutes in DFS-ESD group (t=1.776, P=0.084). The modified operation time of DFS-ESD group was (11.9±2.8) minutes, which was significantly shorter than (17.9±6.6) minutes in conventional ESD group (t=3.425, P=0.002). The hospital stay was (2.3±0.6) days and (2.0±0.5) days in conventional ESD group and DFS-ESD group, respectively, without significant difference (t=1.436, P=0.160). No patient was transferred to surgery, and no delayed bleeding or perforation occurred in either group. There was no recurrence or primary tumor-related death, and all the patients recovered well during a follow-up period of 14(1-24) months. Conclusion Dental floss traction-assisted ESD for rectal neuroendocrine neoplasm can simplify operation and ensure negative basal margin.