Objective To investigate the mechanism of inter fe ron-? (IFN?) in preventing hepatic fibrosis in rat experimental model . Methods Thirty-six male Sprague-Dawley rats were divide d into three groups randomly: group A(normal controls)of 12 rats were given norm al food and water and received subcutaneous injection of peanut oil twice weekly ; group B (fibrotic model)and group C (IFN? prevention) with 12 rats in eac h were induced by carbon terrachloride, high cholesterol and low protein. Group C were treated with intramusclular injections of IFN? in saline, administered daily at the doses of 1?10 5U. At the end of the sixth week, all the rats in each group were killed, the liver function was examined and the samples of t he liver obtained by biopsy were submitted to histological liver fibrosis studie s. The expressions of ?-smooth muscle actin in hepatic tissues were detect ed with immunohistochemical methods. The effect of IFN? on apoptosis of hep atic stellate cells (HSC) were investigated under electron microscope. Results The level of hepatic collagen Ⅰand Ⅲ and serum PC Ⅲ, HA, and LN in group C was significantly lower than that of group B under lig ht microscope (P

Objective To study the efficacy of sodium profile combined with ultrafiltration profile in preventing intradialytic hypotension and changes of the sodium level in blood plasma after hemodialysis. Methods 10 patients with maintenance hemodialysis were chosen randomly. Every patient underwent with conventional hemodialysis treatment and sodium profile combined with ultrafiltration profile treatment 5 times alternatively. And then the blood pressure changes. HR changes, ultrafiltration volume changes and clinical symptoms were observed during treatments. And also after HD, the sodium level in blood plasma was observed. Results The blood pressure decrease of sodium profile combined with ultrafiltration profile evidently reduced the conventional HD treatments( P＜0.01 ).Ultrafiltration volume of the former evidently increased compared with that of the latter(P＜0.01 ). The sodium level in blood plasma after HD was not significantly changed compared with before HD(P＞0.05). Conclnsion Sodium profile combined with ultrafiltration profile diminishes the episodes of hypotension evidently and increases the ability to endure sufferirgs to patients and does not increase the sodium level in blood plasma. So it is an effective medical treatment.

No abstract available.
Pneumonia*

No abstract available.
Mitral Valve* ; Pulmonary Edema* ; Rupture*

No abstract available.

No abstract available.
Pulmonary Embolism*

No abstract available.
Cisplatin* ; Cytarabine* ; Drug Therapy* ; Pleural Effusion, Malignant*

Cough is one of the most common symptoms that can be occasionally very distressful and persistently troublesome. Chronic cough is usually defined as a cough persisting for three weeks or longer. The most common etiologies of chronic cough are postnasal drip, asthma, and gastroesophageal reflux, and more than one causes can be identified. Therapeutic trial with decongestants/first-generation antihistamines is usually effective in the diagnosis and management of postnasal drip syndrome. Even cough without postnasal drip can be improved with decongestant/antihistamine. Methacholline challenge bronchoprovocation test is indicated for the exclusion of asthma. The 24-hour esophageal pH monitoring is usually not indicated unless the symptoms are not improving despite the medical management and lifestyle modification for gastroesophageal reflux. Cough may be caused by gastroesophageal reflux in cases not complaining of heartburn or a sour taste in the mouth. Korean patients frequently confuse postnasal drip or throat clearing with sputum from the lower respiratory tract. There is an increasing attention to the pertussis in adults. The laryngeal spasm, that can cause a brief episode of choking sense with cough, is still not well recognized even among physicians. The bronchodilators are to frequently prescribed because many patients and physicians confuse throat clearing with cough or sputum. On the contrary, codein is too much reserved in the management of cough.
Adult ; Airway Obstruction ; Asthma ; Bronchodilator Agents ; Cough* ; Diagnosis ; Esophageal pH Monitoring ; Gastroesophageal Reflux ; Heartburn ; Histamine Antagonists ; Humans ; Laryngismus ; Life Style ; Mouth ; Pharynx ; Respiratory System ; Sputum ; Whooping Cough

No abstract available.
Dyspnea* ; Electrocardiography* ; Oxygen*

Objective To explore the effect of N -acetylcysteine(NAC)in adjunctive treatment of neonatal bronchopneumonia and its influence on serum inflammatory factors.Methods 62 neonatus with bronchopneumonia treated in our hospital from June 2012 to December 2014 were randomly divided into observation group(32 cases)and control group(30 cases)with random number table.The control group was treated with basic therapy,such as relieving a cough and asthma,defervescing,oxygen inhalation,keeping respiratory tract unobstructed,nutritional support,while the observation group was added aerosol inhalation of NAC on the basis of basic therapy.Then the effect of the average time of body temperature returned to normal,the disappearance time of cough,asthma and pulmonary rale,and average hospitalization days of two groups were observed and compared,the levels of serum tumor necrosis factor -α(TNF -α), interleukin -1(IL -1),interleukin -6(IL -6)and interleukin -10(IL -10)of the two groups before and after treatment were detected.Results The total effective rate of the observation group was 90.63%,which was higher than 70% of the control group (χ2 =4.220,P <0.05).The average time of body temperature returned to normal, disappearance time of cough asthma and pulmonary rale,and average hospitalization days of the observation group were shorter than those of the control group (t =-4.211,-3.472,-4.240,-5.413,-7.822,all P <0.05).The levels of serum TNF -α,IL -1,IL -6 and IL -10 of the observation group after treatment were lower than those of the control group (t =-6.421,-3.892,-15.452,-9.773,all P <0.05).Conclusion Using aerosol inhalation of NAC in adjunctive treatment of neonatal bronchopneumonia can significantly improve the clinical effect and shorten the course of disease,meanwhile,it will eases the systemic inflammatory response to damage the organs by regulating the level of inflammatory factors,which is good for the recover of neonatus as soon as possible.