Granular cell tumours are uncommon benign lesions with a predilection for the head and neck region. We report 9 cases of this rare tumour seen at the National Skin Centre, Singapore, between 1996 and 2006. Five patients were female and four were male. Patient ages were between 15 to 66 years, with a mean of 37.1 years. All 9 patients presented with an asymptomatic painless mass varying from a 1 year to 10 years duration, with a mean duration of 4 years. 6 of the patients were Chinese, 2 were Indian and 1 was Sri Lankan. Five tumors were in the head and neck, three were in the groin or genital regions, and one was in the limb. The tumours ranged in size from 0.3 cm (in the scrotum) to 2.5 cm (in the neck). On examination, none of the lesions had any features of malignancy. The pre-operative diagnosis was dermatofibroma in 3 patients, epidermal cyst in 5 patients, and adnexal tumour in 1 case. For 1 of the patients, there were 2 synchronous tumours present in the scrotum. Excision biopsy was performed for all patients and histology confirmed the diagnosis.

Amalgam has been widely used in dentistry and its components may cause some oral mucosal changes (OMC), commonly presenting as oral lichenoid lesions (OLLs), acute or generalized sensitivity reaction or amalgam tattoo. Our objective was to determine the demographic and clinical profile of patients with and without OMC adjacent to their amalgam restorations (AR) and to evaluate the prevalence and types of AR-related OMC and associated clinical parameters.Materials and methods: In this retrospective cross-sectional study, 83 outpatients attending the Primary Dental Care Unit at the Faculty of Dentistry, University Malaya wereexamined for the presence of AR-related OMC. The studyperiod was from early to mid July 2016. Firstly, patients’ personal details (age, gender, medical status, social habits) were analyzed and history of AR (the age, condition and number of restorations) was determined. Clinical examination of patient’s oral cavity was carried out to detect any AR-related OMC. The data collected was analyzed using SPSS 12.0.1 Result: Approximately 14.6 % patients had OMC. OLLs and amalgam tattoo made up 1.2% and 13.4% respectively. Females (8.4%) had higher predilection and Chinese were more commonly affected (8.4%). Social habits were not associated with OMC. Certain systemic diseases, age (p=0.005) and duration of amalgam (p=0.007) in the oral cavity were significant risk factors for OMC. Conclusions: Present findings suggest that AR-related OMC is uncommon. Three key parameters namely systemic diseases, patient’s age and duration of AR were identified as significant risk factors predisposing to the development of OMCs.